Endocrine Abstracts

Background: Vitamin D (25(OH)D) deficiency is a global public health issue. An association with obesity and diabetes has been described in adult and paediatric populations. This study investigates the prevalence of 25(OH)D deficiency and its correlates in population of Emirati children and adolescents attending a large diabetes centre in the United Arab Emirates.Methods: Participants aged 4-19 years were selected based on diabetes status [type 1 diabetes...

Case history: A 51 year old lady was referred to Endocrinology with low plasma cortisol, hyperprolactinaemia and galactorrhoea. Extensive past medical history included primary hypothyroidism, B12 deficiency, diaphragmatic paralysis requiring NIV, recurrent aspergillomas, sino-atrial node disease with PPM, immunodeficiency, inflammatory arthropathy and autoimmune pancreatic insufficiency. She took numerous medications:- Itraconazole 100 mg daily, Levothyroxine 75 μg daily,...

: We report a case of a 56-year-old gentleman who presented to the endocrine clinic with erectile dysfunction. He had elevated SHBG levels, MCV, gamma GT, ferritin, iron and markedly elevated testosterone and transferrin saturation (GGT 167 IU/l, ferritin 1128 ug/l, testosterone 62.5 nmol/l). He had a marginally low platelet count (123X109/l). He denied ever taking testosterone supplements. His calculated free testosterone was normal. His full blood count was otherwise unremar...

: We report a case of a 56-year-old gentleman who presented to the endocrine clinic with erectile dysfunction. He had elevated SHBG levels, MCV, gamma GT, ferritin, iron and markedly elevated testosterone and transferrin saturation (GGT 167 IU/l, ferritin 1128 ug/l, testosterone 62.5 nmol/l). He had a marginally low platelet count (123X109/l). He denied ever taking testosterone supplements. His calculated free testosterone was normal. His full blood count was otherwise unremar...

A 58 year old female, with a 15 year history of hypertension and recent poor control, was admitted to the emergency department after an out of hospital cardiac arrest due to ventricular fibrillation requiring DC cardioversion. Initial investigations showed a metabolic alkalosis with profound hypokalaemia at 1.7 mmol/l. In view of lateral ST depression on the ECG post-resuscitation, she underwent an urgent coronary angiogram which demonstrated unobstructed coronary arteries. Wh...

Background: Normocalcaemic primary hyperparathyroidism (NPHPT) can be considered as an early biochemical manifestation of hypercalcaemic primary hyperparathyroidism (PHPT). Vitamin D repletion and exclusion of other conditions is recommended before diagnosing NPHPT. It is often challenging to distinguish Vitamin D deficiency associated secondary hyperparathyroidism (SHPT) from NPHPT and the two conditions may coexist. A parathyroid function (PF) index [(Parathyroid hormone (PT...

Due to availability of easy routine blood testing, normocalcaemic primary hyperparathyroidism is increasingly seen. However, due to its mild nature, it often poses diagnostic difficulties. We present a case of 65 year old gentleman who was diagnosed with osteoporosis in 2015. He had a history of traumatic fractures of tibia, fibula and calcaneum in 2013. He was later diagnosed with unexplained osteoporosis in 2015 (T-score of hip −2.5 and T-score of spine −1.2) and...

Endocrinopathies are common complications following cancer therapy and may occur decades later. We present a case of 37 year old lady with a background of chronic myeloid leukaemia (CML) which was treated with sibling allogenic stem cell transplant and total body irradiation in 2002. She was noted to have elevated calcium levels with raised PTH 10 years later. In view of young age, she underwent genetic screening for MEN1 through buccal swab as her lymphocytes were not suitabl...

Hypogonadism persisting in males with macroprolactinoma requires exogenous testosterone replacement therapy but this may cause secondary elevations of prolactin. We present a case of a 44 year old gentleman who was diagnosed with macroprolactinoma after being investigated for ‘abnormal thyroid function tests’ with a low T4 and a normal TSH. He reported a few years’ history of increasing weight gain, lethargy, generalised aches and pains, occasional headaches and...

Case history: A 56 year old man presented with a few months history of diffuse bone pain affecting his arms, legs, ribs and particularly his left hip. Past medical history included well controlled HIV infection, hepatitis B co-infection, peripheral neuropathy associated with HAART, lipoatrophy, Kaposi’s sarcoma, ADHD, type 2 diabetes mellitus, and a history of previous Fanconi’s syndrome associated with Tenofovir Disoproxil Fumarate (TDF) 8 years ago. At his initial ...