Searchable abstracts of presentations at key conferences in endocrinology

ea0029oc5.2 | Obesity Basic | ICEECE2012

Production of galectin-1, -3, -9 and -12 in adipose tissue of lean and obese mice

Rhodes D. , Pini M. , Montero-Melendez T. , Cooper D. , Perretti M. , Fantuzzi G.

Introduction: Obesity is characterized by an expanded and chronically inflamed adipose tissue (AT). The galectin (Gal) family of proteins exerts a variety of activities, including regulation of inflammation and adipogenesis.Methods: We used RT-PCR, ELISA and flow cytometry to evaluate regulation of expression and production of 4 members of the Gal family – Gal1, Gal3, Gal9 and Gal12 – in visceral (VAT) and subcutaneous (SAT) adipose tissue of m...

ea0002sp10 | Molecular Evolutionary Endocrinology | SFE2001


Montero M , Yon L , Alexandre D , Anouar Y , Chartrel N , Kikuyama S , Dufour S , Vaudry H

Growth hormone-releasing hormone (GHRH) and pituitary adenylate cyclase-activating polypeptide (PACAP) belong to the same superfamily of regulatory neuropeptides which also comprises VIP, glucagon, secretin and GIP. Both GHRH and PACAP have been characterized on the basis of their hypophysiotropic activities. In the course of vertebrate evolution, the primary structure of GHRH has markedly diverged while the sequence of PACAP has been remarkably well preserved. In mammals, GHR...

ea0081oc6.2 | Oral Communications 6: Endocrine-Related Cancer | ECE2022

Translational evidence for splicing factor RBM22 as a novel prognostic biomarker and therapeutic target in prostate cancer

Saez-Martinez Prudencio , Jimenez-Vacas Juan M , Montero-Hidalgo Antonio J , Rosa-Herencia Ana D , Herrero-Aguayo Vicente , Leon-Gonzalez Antonio J , Sanchez-Sanchez Rafael , Gonzalez-Serrano Teresa , Gomez-Gomez Enrique , Gahete Manuel D , Luque Raul M

Prostate cancer (PCa) is one the leading causes of cancer-related deaths among men in developed countries. Therefore, identification of novel molecular and therapeutic approaches to tackle this pathology are urgently needed. In this scenario, our group has recently reported that elements of the cellular machinery controlling alternative splicing processes might be used as potential novel therapeutic tools against PCa and castration-resistant PCa (CRPC). In this context, RBM22 ...

ea0056oc9.4 | Thyroid from basics to clinics | ECE2018

Identification of an epigenetic biomarker panel for predicting the development of distant metastases in differentiated thyroid cancer

Rodriguez Helena , Zafon Carles , Villalmanzo Nuria , Cerda Lorena , Iglesias Carmela , Real Jordi , Gil Joan , Hesselink Esther N. Klein , van Hemel Bettien M. , Montero-Conde Cristina , Reverter Jordi L. , Mauricio Didac , Puig-Domingo Manel , Robledo Mercedes , Links Thera P. , Jorda Mireia

Background: Differentiated thyroid cancer (DTC) is usually associated with an excellent prognosis. The main cause of death is due to distant metastases, but distant metastatic DTC (dmDTC) presents an interpatient heterogeneity. Some patients with distant metastases live with stable disease for many years, while others die very early. Still no effective biomarkers are available to predict either which patients will eventually develop distant metastases or what will be the final...