Searchable abstracts of presentations at key conferences in endocrinology
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20th European Congress of Endocrinology

Barcelona, Spain
19 May 2018 - 22 May 2018

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ECE 2018, 19 - 22 May 2018; Barcelona, Spain

Oral Communications

Thyroid from basics to clinics

ea0056oc9.1 | Thyroid from basics to clinics | ECE2018

Increased urinary iodide precedes hypothyroidism in Dehal1 knockout mice

Gonzalez-Guerrero Cristian , Lucia Federico S. , Alcaina Yago , Gonzalez-Lopez Ana M. , Buno Antonio , Mora Roberto , De Miguel Maria Paz , Moreno Jose C.

Thyroid hormones (TH) synthesis requires iodine, a scarce element whose recycling is mediated by the iodotyrosine dehalogenase (encoded by the DEHAL1 gene) through deiodination of mono- and di-iodotyrosines. In humans, biallelic mutations in DEHAL1 lead to a severe form of congenital hypothyroidism (CH) non detectable by neonatal screening programs, which involves the risk of mental retardation. The timing and triggering factors of this particular type of hyp...

ea0056oc9.2 | Thyroid from basics to clinics | ECE2018

Anti-tumoral effects of metformin on metastatic bone lesions of thyroid cancer

Cho Sun Wook , Shin Hyo Sik , Sun Hyun Jin , Park Young Joo , Yi Ka Hee

Background: Metformin plays anti-tumoral roles in human cancers including breast and thyroid. However, its effects on metastatic lesions are undetermined. We studied the effects of metformin on bone metastasis of thyroid cancer.Method: Luciferase-tagged anaplastic FRO and follicular FTC 133 thyroid cancer cells were used. In vivo effects of metformin were evaluated in both ectopic tumor model and bone metastasis model generated by intratibial injection.<...

ea0056oc9.3 | Thyroid from basics to clinics | ECE2018

A mouse model of BRAF V600E mutated papillary thyroid cancer imitating sporadic conditions

Jakubikova Iva , Schoultz Elin , Johansson Ellen , Liang Shawn , Patyra Konrad , Kero Jukka , Zak Pavel , Nilsson Mikael

Introduction: Worldwide constantly rising incidence of thyroid cancer promotes research activities. Nowadays the most speculated issue is the clinical significance of BRAF mutation. For sure BRAF mutation is a cancer-specific somatic mutation consistent with papillary thyroid cancer phenotype, otherwise, its role in tumor aggressiveness, progression, and the overall poor outcome is controversial. As far as several clinical studies claim opposing opinions, the learning aspect o...

ea0056oc9.4 | Thyroid from basics to clinics | ECE2018

Identification of an epigenetic biomarker panel for predicting the development of distant metastases in differentiated thyroid cancer

Rodriguez Helena , Zafon Carles , Villalmanzo Nuria , Cerda Lorena , Iglesias Carmela , Real Jordi , Gil Joan , Hesselink Esther N. Klein , van Hemel Bettien M. , Montero-Conde Cristina , Reverter Jordi L. , Mauricio Didac , Puig-Domingo Manel , Robledo Mercedes , Links Thera P. , Jorda Mireia

Background: Differentiated thyroid cancer (DTC) is usually associated with an excellent prognosis. The main cause of death is due to distant metastases, but distant metastatic DTC (dmDTC) presents an interpatient heterogeneity. Some patients with distant metastases live with stable disease for many years, while others die very early. Still no effective biomarkers are available to predict either which patients will eventually develop distant metastases or what will be the final...

ea0056oc9.5 | Thyroid from basics to clinics | ECE2018

Sentinel lymph node biopsy using methylene blue dye in papillary and medullary thyroid carcinomas and microcarcinomas in decision for lateral neck dissection

Dzodic Radan , Santrac Nada , Markovic Ivan , Goran Merima , Buta Marko , Pupic Gordana

Introduction: Surgical management of clinically N0 (cN0) patients with thyroid carcinomas remains debatable due to various reported frequencies of lymph node (LN) metastases. Preoperative ultrasound identifies only half of LN metastases found at surgery. The aim of this report was to present our experience with sentinel lymph node biopsy (SLNB) of jugulo-carotid regions, after methylene blue dye (MBD) mapping and frozen section analysis (FSA), in detection of LN metastases in ...