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20th European Congress of Endocrinology

Barcelona, Spain
19 May 2018 - 22 May 2018

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ECE 2018, 19 - 22 May 2018; Barcelona, Spain

Oral Communications

MicroRNAs as biomarkers in endocrine diseases

ea0056oc8.1 | MicroRNAs as biomarkers in endocrine diseases | ECE2018

Plasma microRNA expression in patients with Cushing’s disease differs from ACTH-ectopic Cushing’s syndrome

Belaya Zhanna , Khandaeva Patimat , Nikitin Alexey , Solodovnikov Alexander , Sitkin Ivan , Grebennikova Tatjana , Vorontsov Alexander , Rozhinskaya Liudmila , Melnichenko Galina , Dedov Ivan

According to previous research microRNA (miR) are expressed differently in corticotropinoma and ACTH-secreting neuroendocrine tumors. MiR are released into circulation by several mechanisms and considered to be promising biomarkers.Objective: To evaluate whether preselected miR are differently expressed in plasma samples of patients with ACTH-dependent Cushing’s syndrome (CS).Materials and methods: The blood samples were colle...

ea0056oc8.2 | MicroRNAs as biomarkers in endocrine diseases | ECE2018

MicroRNA expression profiling and functional annotation analysis of their targets in patients with diabetic kidney disease

Assmann Tais Silveira , Recamonde-Mendoza Mariana , Costa Aline , Punales Marcia , Tschiedel Balduino , Canani Luis Henrique , Bauer Andrea Carla , Crispim Daisy

Context: Diabetic kidney disease (DKD) is a common microvascular complication that affects approximately 40% of patients with diabetes mellitus (DM). This complication is the leading cause of end-stage renal disease (ESRD) in patients starting renal replacement therapy and is associated with increased cardiovascular mortality. Although a tight glycemic control is able to reduce the development and delay the progression of DKD, current therapies are still not totally effective ...

ea0056oc8.3 | MicroRNAs as biomarkers in endocrine diseases | ECE2018

Circulating levels of microRNAs associate with blood pressure and left ventricular mass in primary hypertensive patients

van Kralingen J.C. , Larsen C.K. , Connell J.M. , Freel E.M. , Zennaro M.C. , MacKenzie S.M. , Davies E.

Introduction: MicroRNA (miRNA) has been shown to post-transcriptionally regulate physiological systems modulating blood pressure, including the adrenal biosynthesis of aldosterone. This raises the possibility that levels of specific miRNAs circulating in plasma might reflect these functional effects and have diagnostic value in the identification of hypertension and its various underlying causes. In a previous study, we measured plasma levels of miRNAs originating from the miR...

ea0056oc8.4 | MicroRNAs as biomarkers in endocrine diseases | ECE2018

Detecting blood micro-RNAs and proteins associated with Graves’ disease and orbitopathy

Biscarini Filippo , Zhang Lei , Masetti Giulia , Covelli Danila , Colucci Giuseppe , Eckstein Anja , Kaiser U , Draman Shazli , Muller Ilaria , Lucini Luigi , Ludgate Marian , Salvi Mario

Graves’ Disease (GD) affects about 2% of the population in the UK, with female predominance. A proportion of GD patients (5–50%) develop orbitopathy (GO), which is characterized by tissue remodeling in the orbit leading to protrusion of the eye (proptosis). Blood biomarkers associated with GD or GO could be useful diagnostic or prognostic tools for researchers and clinicians. Within the framework of INDIGO IAPP-612116 (Investigation of Novel biomarkers and Definition...

ea0056oc8.5 | MicroRNAs as biomarkers in endocrine diseases | ECE2018

MicroRNA profiles in diabetic octogenarians with and without historical and prospective hip fractures

Foessl Ines , Kotzbeck Petra , Francic Vito , Haudum Christoph , Groselj-Strehle Andrea , Piswanger-Solkner Jutta Claudia , Dobnig Harald , Fahrleitner-Pammer Astrid , Obermayer-Pietsch Barbara

Objective: Type 2 diabetes mellitus (T2DM) patients have a higher risk for bone fractures, especially in the elderly. However, bone mineral density (BMD) does not reflect their increased bone fragility, potentially based on disturbed bone metabolism or quality. MicroRNAs are promising new biomarkers for fracture risk detection. This study aimed to find specific miRNAs in a large cohort of elderly patients with and without T2DM at risk for osteoporotic fractures.<p class="a...