Searchable abstracts of presentations at key conferences in endocrinology

ea0031p182 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2013

Vitamin B12 and folate imbalance induces cholesterol synthesis and endoplasmic reticulum stress in human adipocytes

Adaikalakoteswari Antonysunil , Moore Jonathan , Ciara Mccarthy , Voyais Philip , Mcternan Philip , Saravanan Ponnusamy , Tripathi Gyanendra

Adipose tissue (AT) plays a central role in integrating energy metabolism and glucose homeostasis. It is the major site of fatty acid storage as triglycerides and is body’s largest cholesterol pool. In AT cholesterol is mostly found in its free, non-esterified form. There is accumulating evidence that cholesterol imbalance in AT is closely associated with adipocyte dysfunction and obesity-mediated metabolic complications, including low levels of high-density lipoprotein c...