ea0011oc27 | Diabetes and metabolism | ECE2006
Michailidou ZM
, Coll APC
, Morton NMM
, Kenyon CJ
, ORahilly S
, Seckl JR
, Chapman KE
Inactivating mutations of the POMC gene in humans and mice result in a complex phenotype of hyperphagia, obesity and glucocorticoid (GC) deficiency, but without many features of metabolic syndrome. We have previously shown that replacement of GC in Pomc−/− mice exacerbates their hyperphagia, increases fat mass and elevates plasma leptin and insulin. We have now examined key determinants of glucocorticoid action, including glucocorticoid receptor (...