ea0077s2.1 | Nuclear receptors in male reproduction | SFEBES2021
Jarvis Sheba
, Gethings Lee
, Gadaleta Raffaella
, Leach Damien
, Claude Emmanuelle
, Moschetta Antonio
, Winston Robert
, Williamson Catherine
, Bevan Charlotte
Liver X receptors (LXRs) are are ligand-dependent transcription factors, members of the nuclear receptor superfamily of transcription factors. In humans two LXR isoforms exist, LXRα (NR1H3) and LXRβ (NR1H2). LXRα is expressed predominantly in metabolically active tissues, while LXRβ is expressed in the majority of tissues. They have long been known to have critical roles in regulation of lipid metabolism, particu...