Searchable abstracts of presentations at key conferences in endocrinology

ea0038p363 | Reproduction | SFEBES2015

Vitamin D and foetomaternal immunity: effects on uterine natural killer cells

Tamblyn Jennifer , Jeffery Louisa , Susarla Radhika , Moss Paul , Hewison Martin , Kilby Mark

Vitamin D deficiency is prevalent in pregnant women. Active vitamin D (1,25(OH)2D3) exerts important non-classical immune-regulatory effects, and the maternal placenta (decidua) is a potential target for this. CD56+ -uterine natural killer (uNK) cells are the most prominent cell type in the decidua during early pregnancy. Given their critical role in foetal implantation and placentation, we hypothesised that uNK cells are a pivotal immunomodula...