Searchable abstracts of presentations at key conferences in endocrinology

ea0031p28 | Bone | SFEBES2013

Not the end of brown tumours: three cases within 12 months

McElwaine Fred , Courtney Hamish , Mullan Karen

A 37-year-old woman presented with a short history of left arm pain. X-ray indicated a lytic lesion of the scapula. Calcium was elevated at 3.25 mmol/l (normal 2.2–2.6) with parathyroid hormone (PTH) 936 pg/ml (5–70). Upon questioning she reported nocturia, polydipsia and dyspepsia. Magnetic resonance imaging revealed brown tumours in the scapula, clavicle and hand. A superior parathyroid adenoma was excised with normalisation of calcium. Bone biopsy of the scapular ...

ea0031p309 | Pituitary | SFEBES2013

A case of persistent Mullerian duct syndrome

Graham Una , McCracken Emma , Mullan Karen

A 45-year-old man who works as a psychotherapist was referred with an incidental finding of a rudimentary uterus and bilateral pelvic gonads on pelvic computerized tomogram and magnetic resonance imaging. This was performed for investigation of abdominal pain which has since settled. As far as he is aware he was born without complications and developed normally through childhood. He progressed through puberty uneventfully with voice changes by 13 years and shaving by 16 years....

ea0094p285 | Thyroid | SFEBES2023

Dietary and supplemental iodine intake in a cohort of pregnant women in Northern Ireland

Kayes Lucy , Mullan Karen , Woodside Jayne

Since the 1990’s, eight survey studies have demonstrated iodine deficiency during pregnancy across the UK and Ireland. Both countries lack an iodine fortification programme, unlike many European countries. Therefore, women must rely on dietary adjustments and supplementation to achieve the iodine intake required in pregnancy. The World Health Organisation (WHO) recommends an increase from 150 to 250 µg/day during pregnancy. Pregnant women in Belfast were recruited to...

ea0077oc6.6 | Thyroid | SFEBES2021

Forty years’ experience of national screening programme for congenital hypothyroidism in Northern Ireland.

Kayes Lucy , Darrat Milad , Woodside Jayne , Mullan Karen , Abid Noina

Northern Ireland was one of the first participating sites for the UK screening programme for congenital hypothyroidism (CHT) started 40 years ago. This study aimed to explore any changing patterns in incidence over time. Enrolment in the programme has remained high throughout the 40 years (> 98%). The cut-off value for neonatal thyroid stimulating hormone (nTSH) on day 5-8 of life reduced in ~1995 from 10 mU/l to 8 mU/l to improve sensitivity and specificity. There was a s...

ea0086p131 | Thyroid | SFEBES2022

Therapeutic database of anti-thyroid medication over 10 years in northern ireland (NI) 2010-2019: trends, demographics and deprivation

Kayes Lucy , McHenry Claire , Woodside Jayne , Mullan Karen

Anonymised therapeutic data has been available for all patients in NI across 364 general practices since 2008. The database records age, gender, trusts and postcodes, which allows for spatial deprivation analyses. Patients were categorised in deciles (1-most deprived, 10-least) according to published criteria. We examined carbimazole (CBZ) and propylthiouracil (PTU) prescriptions over 10 years (2010 to 2019). Patients treated definitively with surgery/radioiodine are invariabl...

ea0091cb28 | Additional Cases | SFEEU2023

Thyroid function and Self Help

Bonanos Stathis , Mullan Karen , J Hunter Steven , Wallace Helen

A 60 year old nurse presented to the emergency department with palpitations, itchy skin, shortness of breath, diarrhoea, insomnia, weight loss and feeling hot /clammy. She felt her symptoms were in keeping with the menopause although she had been amenorrhoeic for six years. Thyroid function tests revealed fT4 73 pmol/land TSH <0.01 mIU/lhaving been normal six months previously. She was started on carbimazole 40 mg/day and was seen urgently in clinic. She reported to feelin...

ea0091p4 | Poster Presentations | SFEEU2023

A case of acute intermittent porphyria in a pregnant lady with hyponatraemia

Haq Rizwan , Murray Emma , Hamilton Paul , Wallace Helen , Mullan Karen

Case History: A 27 year-old lady, seven weeks gestation presented to ED during her second pregnancy with abdominal pain, vomiting, constipation and hyponatraemia (Na = 114mmol/l). She had attended twice earlier during her pregnancy with presumed hyperemesis gravidarum. Because urinary sodium was elevated at 181mmol/l, dehydration was deemed unlikely and she was initially treated as SIADH with 1.2L fluid restriction and 2.7% 200mls of hypertonic saline. Sertraline was held. Rep...

ea0044oc6.4 | Pregnancy and Reproductive Health | SFEBES2016

Iodine nutritional status among pregnant women and their offspring in Northern Ireland (NI)

McMullan Paul , Hamill Lesley , McCance David , Woodside Jayne , Mullan Karen

Background: A re-emergence of mild iodine deficiency in the United Kingdom (UK) has been reported. A recent UK study suggested a dose dependent relationship between mild maternal deficiency and a number of childhood cognitive scores. The World Health Organisation defines sufficiency in a population as a median urinary iodine concentration (UIC) of ≥100 μg/l in non-pregnant women and infants and ≥150 μg/l during pregnancy. It also recommends a daily intake...

ea0038p442 | Thyroid | SFEBES2015

A cross-sectional survey to determine iodine status of school girls living in Northern Ireland

McMullan Paul , Hamill Lesley , Woodside Jayne , Dolan Katie , Mullan Karen

Iodine deficiency is the most common cause of preventable mental impairment worldwide. Recent evidence suggests the re-emergence of mild iodine deficiency in the UK. A recent multicentre survey in the UK reported that 68% of school girls were iodine deficient with the lowest levels seen in Northern Ireland (NI). Unlike many countries, the UK does not have a salt or food iodination program. World Health Organisation defines deficiency as follows: mild 50–99 μg/l; mode...

ea0038p445 | Thyroid | SFEBES2015

A cross sectional survey of dietary iodine intake in pregnant women living in Northern Ireland

McMullan Paul , Woodside Jayne , Hamil Lesley , Mullan Karen

Adequate iodine intake during pregnancy is required for the production of thyroid hormones and brain development in the foetus. Recent evidence has suggested re-emergence of mild iodine deficiency in the UK but there are few studies that have specifically looked at iodine intake in pregnant women. Current World Health Organisation recommendation is for 250 mcg/day intake of iodine in pregnancy and the following are good sources of dietary iodine: 1 pint milk (~140–220 mcg...