ea0041oc12.4 | Obesity | ECE2016
Quarta Carmelo
, Clemmensen Christoffer
, Yang Bin
, Zhu Zhimeng
, Muller Timo D
, DiMarchi Richard D
, Finan Brian
, Tschop Matthias H
Abstract: Inflammation plays a contributing role in the pathogenesis of several metabolic disorders, including type 2 diabetes and obesity. Intriguingly, obesogenic diets induce markers of hypothalamic inflammation and neuronal injury in both rodents and humans, suggesting that targeting inflammatory pathways in the hypothalamus might represent a novel strategy to control energy metabolism. Unfortunately, the majority of steroid-based anti-inflammatory drugs are fraught with a...