Searchable abstracts of presentations at key conferences in endocrinology
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18th European Congress of Endocrinology

ea0041oc12.1 | Obesity | ECE2016

Functional characterization of naturally occurring mutations in the melanocortin receptor accesory protein 2 (MRAP2)

Biebermann Heike , Schonnop Laura , Herrfurth Nikolas , Volckmar Anna-Lena , Muller Anne , Peters Triinu , Herpertz Stephan , Antel Jochen , Hebebrand Johannes , Kleinau Gunnar , Hinney Anke

Introduction: The melanocortin 4 receptor (MC4R) is the most important hypothalamic expressed G protein coupled receptor in weight regulation. Mutations in the MC4R are the most frequent genetic cause of obesity. Recently an accessory protein of the MC4R (melanocortin receptor accessory protein 2, MRAP2) was discovered that was found to play a role in body weight regulation. MRAP2 deficient mice develop early-onset obesity. The mechanisms of disturbed weight regulation is pote...

ea0041oc12.2 | Obesity | ECE2016

Female 5β-reductase knockout mice are protected from diet induced obesity, insulin resistance and glucose intolerance

Gathercole Laura , Chapman Matthew , Larner Dean , Klusonova Petra , Penning Trevor , Lavery Gareth , Odermatt Alex , Tomlinson Jeremy

Steroid hormones and bile acids are potent regulators of metabolic phenotype. The enzyme 5β-Reductase (AKR1D1) has a crucial role in bile acid synthesis and also generates 5β-reduced dihydrosteroid metabolites, regulating intra-cellular steroid availability though the clearance of cortisol, testosterone, androstenedione and progesterone. As AKR1D1 sits at the interface of bile acid synthesis and steroid metabolism, we have hypothesised that it plays a key role in met...

ea0041oc12.3 | Obesity | ECE2016

Effects of weight loss and long-term weight maintenance with diets varying in protein and glycemic index on circulating pro-neurotensin in the Diet, Obesity, and Genes (DiOGenes) Study: a randomized, controlled trial

Rudovich Natalia , Bernigau Wolfgang , Pivovarova Olga , Osterhoff Martin , Sparwasser Andrea , Bergmann Andreas , Struck Joachim , van Baak Marleen A , Jebb Susan A , Papadaki Angeliki , Alfredo Martinez J , Handjieva-Darlenska Teodora , Kunesova Marie , Hager Jorg , Valsesia Armand , Viguerie Nathalie , Langin Dominique , Astrup Arne , Saris Wim H M , Pfeiffer Andreas F H

Aims: Elevated levels of neurotensin (NT), a neurotransmitter and postprandial secreted intestinal hormone, are associated with an increased risk of diabetes, cardiovascular disease and breast cancer. Here we studied the regulation of circulating pro-NT (a stable NT precursor fragment) by weight loss and dietary interventions.Methods: DiOGenes is a pan-European controlled dietary intervention study in overweight adults who first lost body weight on an 8-...

ea0041oc12.4 | Obesity | ECE2016

GLP-1 directed delivery of dexamethasone ameliorates hypothalamic inflammation and reverses diet-induced obesity

Quarta Carmelo , Clemmensen Christoffer , Yang Bin , Zhu Zhimeng , Muller Timo D , DiMarchi Richard D , Finan Brian , Tschop Matthias H

Abstract: Inflammation plays a contributing role in the pathogenesis of several metabolic disorders, including type 2 diabetes and obesity. Intriguingly, obesogenic diets induce markers of hypothalamic inflammation and neuronal injury in both rodents and humans, suggesting that targeting inflammatory pathways in the hypothalamus might represent a novel strategy to control energy metabolism. Unfortunately, the majority of steroid-based anti-inflammatory drugs are fraught with a...

ea0041oc12.5 | Obesity | ECE2016

GNB3 overexpression causes obesity and metabolic syndrome

Cagla Ozdemir Alev , Wynn Grace M , Katharine Rudd M

Duplication of the guanine nucleotide-binding protein beta subunit 3 (GNB3) gene is associated with early-onset obesity in individuals with an unbalanced chromosome translocation. Additionally, a cytosine to thymine (C825T) polymorphism in GNB3 is associated with hypertension, obesity and metabolic syndrome; however, the mechanism of GNB3-related obesity is unknown. We created BAC-transgenic mice that carry an extra copy of the human risk-allele (T) ...