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18th European Congress of Endocrinology

Oral Communications

Bone & Calcium Homeostasis

ea0041oc11.1 | Bone & Calcium Homeostasis | ECE2016

An increase of bone mineral density in male-to-female and female-to-male transgender persons after one year cross-sex hormonal treatment

Wiepjes Chantal , Vlot Mariska , Klaver Maartje , de Jongh Renate , Lips Paul , Heijboer Annemieke , Fisher Alessandra , Schreiner Thomas , T'Sjoen Guy , den Heijer Martin

Introduction: Estrogen has positive effects on bone mineral density (BMD), in particular in trabecular bone through inhibition of bone resorption. Testosterone increases bone size, but the effect on BMD is less clear. Cross-sex hormonal treatment (CSHT) in transgender individuals can affect BMD. Therefore, the aim of this study is to investigate effects of CSHT on BMD during the first year of treatment in male-to-female (MtFs) and female-to-male (FtMs) transgender persons....

ea0041oc11.2 | Bone & Calcium Homeostasis | ECE2016

Associations of insulin sensitivity with cortical bone geometry in healthy adult men

Verroken Charlotte , Zmierczak Hans , Goemaere Stefan , Kaufman Jean-Marc , Lapauw Bruno

Objective: In type 2 diabetes mellitus, fracture risk is increased despite preserved BMD. This might in part be due to insulin resistance affecting bone geometry; however, studies investigating the associations of insulin sensitivity with bone geometry are lacking. We aimed to explore this relationship in a cohort of healthy, young adult men.Methods: In 1001 healthy men aged 25–45 years, cortical bone geometry was assessed using pQCT (radius and tib...

ea0041oc11.3 | Bone & Calcium Homeostasis | ECE2016

Ultra-trail marathon induces bone response in association with acute and established metabolic changes

Lombardi Giovanni , Sansoni Veronica , Perego Silvia , Vernillo Gianluca , Schena Federico , Merati Giampiero , Baruti Andrea , La Torre Antonio , Banfi Giuseppe

Introduction: Bone and energy metabolisms are deeply related determining a two-way street aimed in regulating the energy utilization [1]. Mountain ultra-marathons are peculiar aerobic performances hardly proving whole body homeostasis [2]. In this study we aimed at investigating and characterizing the metabolic profile (hormones involved in energy metabolism), the metabolic inflammation profile (adipokines), the bone metabolism (bone turnover markers), and their integration (m...

ea0041oc11.4 | Bone & Calcium Homeostasis | ECE2016

The prevalence of GNAS deficiency-related diseases in a large cohort of patients characterized by the EuroPHP network

Marta Elli Francesca , Linglart Agnes , Garin Intza , de Sanctis Luisa , Bordogna Paolo , Grybek Virginie , Pereda Arrate , Giachero Federica , Verrua Elisa , Mantovani Giovanna , Perez de Nanclares Guiomar

The clinical condition resulting from end-organ resistance to parathormone (rPTH), caused by (epi)genetic alterations of GNAS, was termed as Pseudohypoparathyroidism (PHP). The high phenotype heterogeneity, the existence of additional clinical features such as resistance to other hormones (TSH/GHRH/gonadotropins) and Albright’s hereditary osteodystrophy (AHO), led to the distinction of specific PHP subtypes.The purpose of the present work is to prov...

ea0041oc11.5 | Bone & Calcium Homeostasis | ECE2016

Effects of vitamin D supplementation on respiratory muscle strength and physical performance in patients with COPD: a pilot trial

Rafiq Rachida , Prins Henk-Jan , Boersma Wim , Daniels Hans , den Heijer Martin , Lips Paul , de Jongh Renate

Introduction: Although vitamin D is well known for its function in calcium homeostasis and bone mineralisation, several studies have shown an effect on physical function and muscle strength. Also, vitamin D has been associated with pulmonary function and the incidence of airway infections. As vitamin D deficiency is highly prevalent in COPD-patients, supplementation might have a beneficial effect in these patients.Objective: To assess the effect of vitam...