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18th European Congress of Endocrinology

Oral Communications

Reproduction & Endocrine Disruption

ea0041oc10.1 | Reproduction & Endocrine Disruption | ECE2016

Systemic enamel pathologies may be due to anti-androgenic effects of some endocrine disruptors

Jedeon Katia , Loiodice Sophia , Houari Sophia , Lenormand Manon , Berdal Ariane , Babajko Sylvie

There has been increasing concerns over the last 20 years about the potential adverse effects of endocrine disruptors (EDs). Anecdotally, molar incisor hypomineralization (MIH), a recently described enamel pathology, now affecting 15–18% of 6–9 years old children, is increasing concurrently with ED related pathologies. Our previous data show that bisphenol A (BPA) and vinclozolin, two anti-androgenic EDs, impact amelogenesis and enamel mineralization preferentially i...

ea0041oc10.2 | Reproduction & Endocrine Disruption | ECE2016

Human luteinizing hormone (hLH) and chorionic gonadotropin (hCG) display biased agonism at the LH/CG receptor

Riccetti Laura , Akli Ayoub Mohammed , Klett Daniele , Yvinec Romain , Gallay Nathalie , Combarnous Yves , Casarini Livio , Simoni Manuela , Reiter Eric

Human luteinizing hormone (LH) and human choriogonadotropin (hCG) were considered biologically equivalent for decades due to structural similarities and binding to the same receptor (LHCGR). However, LHCGR triggers differential, LH- and hCG-specific, cAMP production, steroidogenesis, ERK and AKT activation and gene expression in granulosa cells. Besides the Gs/cAMP/PKA pathway, hCG and LH bioactivity on β-arrestin- and Gq/PLC-dependent pathways are yet to be determined. W...

ea0041oc10.3 | Reproduction & Endocrine Disruption | ECE2016

LHCGR signaling promotes gonadal-like cell differentiation and proliferation in gonadectomy-induced adrenocortical tumorigenesis in mice

Chrusciel Marcin , Doroszko Milena , Jakobi Meike , Brouze Michal , Ponikwicka-Tyszko Donata , Bernaczyk Piotr , Anisimowicz Slawomir , Wolczynski Slawomir , Toppari Jorma , Huhtaniemi Ilpo , Rahman Nafis

Adrenocortical tumorigenesis in prepubertally gonadectomized (GDX) DBA/2J mice has been attributed to chronically elevated luteinizing hormone (LH) and ectopic expression of luteinizing hormone receptor (LHCGR) and GATA-4 transcription factor. We analyzed now the mechanistic role of LH-LHCGR activation in GDX-induced adrenocortical tumorigenesis in intact and ovariectomized (OVX) wild-type (WT) and Lhcgr-/- mice in the DBA/2J genetic background mice, or by ...

ea0041oc10.4 | Reproduction & Endocrine Disruption | ECE2016

Impaired adipose function in PCOS – evidence that the primary abnormalities are in subcutaneous rather than visceral fat

Siemienowicz Katarzyna , Coukan Flavien , Lerner Avigdor , Franks Stephen , Rae Mick , Duncan Colin

Central obesity and increased visceral adipose tissue (VAT) are key factors contributing to metabolic dysfunction in PCOS. We therefore hypothesized that there would be alterations in the morphology and function of adipocytes from visceral fat depots. The female offspring of pregnant sheep treated biweekly with either 100 mg of testosterone propionate (TP) or vehicle control (C) from day 62–102 of gestation develop a clinically realistic PCOS-like condition. They develop ...

ea0041oc10.5 | Reproduction & Endocrine Disruption | ECE2016

Effect of clomiphene citrate and metformin on testosterone levels in hypogonadal obese men with impaired glucose tolerance (IGT) or type 2 diabetes (DM2)

Pelusi Carla , Giagulli Vito , Baccini Margherita , Fanelli Flaminia , Mezzullo Marco , Fazzini Alessia , Casadio Elena , Prontera Olga , Pagotto Uberto , Pasquali Renato

Low testosterone (T) levels are often found in obese men with metabolic abnormalities, however the mechanism underling this condition is unclear. This study aimed to evaluate the effectiveness of clomiphene citrate (CC) in increasing T levels and improving metabolic control in hypogonadal obese men with IGT or DM2. A randomized cross-over double blind controlled study was conducted in twenty obese hypogonadal caucasian men, mean age 47 ys, classified in IGT (n=11) or ...