Searchable abstracts of presentations at key conferences in endocrinology

ea0025p292 | Steroids | SFEBES2011

Glycyrrhetinic acid disrupts the synthesis of adrenocorticosteroid hormones at multiple sites

Al-Dujaili Emad , Kenyon Christopher , Nicol Moira , Mason Ian

Background and aims: Previously we showed that the bioactive liquorice constituent glycyrrhetinic acid (GA) inhibits not only 11β-hydroxysteroid dehydrogenase enzymes but also the sulphation of corticosteroids by the enzyme sulphotransferase 2A1 (SULT2A1). Since pregnenolone, 17α-hydroxy-pregnenolone, deoxycorticosterone (DOC) and dehydroepiandrosterone (DHEA) are all prime substrates for SULT2A1, GA could have important effects in directing pathways of glucocorticoi...

ea0016p264 | Endocrine disruptors | ECE2008

Investigating the effects of Liquorice consumption on Salivary Steroid hormones profile and blood pressure in healthy volunteers

Al-Dujaili Emad A S , Macdonald Claire , Kenyon Chris J , Nicol Moira

Glycyrrhetinic acid (GA) has diverse in vitro effects as an inhibitor of 11beta hydroxysteroid dehydrogenase (11HSD), 5alpha reductase and hormone receptor binding. However, in vivo GA studies have focussed on the hypertensive effects associated with the syndrome of apparent mineralocorticoid excess (SAME) in which 11HSD inhibition allows glucocorticoid hormones to bind inappropriately to MR and subsequent decreased aldosterone synthesis. Here we consider whether...