Endocrine Abstracts

Atrazine is a chloro-s-triazine herbicide that has been in used worldwide for over 4 decades now. Its endocrine disrupting effects have been shown in mammals but the specific mechanism or mechanisms of action remain unknown. The aim of this study was to evaluate the acute effects of atrazine on testicular antioxidant systems and on some spermatological parameters in rats.Atrazine was administered to wistar rats at a dose equivalent to 120 mg/kg or 200 mg...

Natural and synthetic chemicals such as estrogenic and androgenic compounds have been observed to contribute to the pool of endocrine disruptors in the effluent water from sewage treatment works and may interfere with the endogenous hormonal system regulating reproduction in aquatic organisms. The teleost Zoarces viviparus is a recognized model used in aquatic toxicology due to the existence of a maternal-fetal trophic relationship with embryos/larvae developing in the ...

Glycyrrhetinic acid (GA) has diverse in vitro effects as an inhibitor of 11beta hydroxysteroid dehydrogenase (11HSD), 5alpha reductase and hormone receptor binding. However, in vivo GA studies have focussed on the hypertensive effects associated with the syndrome of apparent mineralocorticoid excess (SAME) in which 11HSD inhibition allows glucocorticoid hormones to bind inappropriately to MR and subsequent decreased aldosterone synthesis. Here we consider whether...

The aim of the study was the analysis of dependencies between sex hormones and metabolic syndrome.Forty-five women with metabolic syndrome and 49 healthy women were examined.The diagnostic criteria of metabolic syndrome: waistline ≥80 cm, waistline/hips index WHI≥0.85 and also having 1 or 2 cardiovascular risk factors: glucose≥100 mg%, RR≥130/80, HDL< 50mg% and TG≥150 mg%.The...

The aim of the work was the analysis of dependencies between sex hormones and functioning of endothelium in women in the climacteric period with metabolic syndrome.Fifty-three women with metabolic syndrome and 45 healthy women were examined.Lipidogram (LDL: cholesterol-LDL, HDL: cholesterol-HDL), triglycerides(TG) and fasting glucose levels were determined. Body mass index BMI and waistline/hips index (WHI) were calculated.<p c...

The AIRE gene (autoimmune regulator) has been identified as an important mediator of central tolerance against ectopically expressed peripheral antigens. Mutatations of AIRE are responsible for autoimmune polyendocrinopathy syndrome type I (APSI) in human characterized by a multiorgan autoimmune disease. Autoimmune hepatitis (AIH) is part of the clinical spectrum in humans and mice. 19% of patients with AIRE mutations develop an autoimmune hepatitis which is characterized by a...

Aim of the study was to evaluate influence of potassium iodide on hormonal thyroid function.In medicine there are widely used medias with large, overphysiologic doses of iodine for both treatment and diagnosis. We investigated influence of high repeated iodine doses on hormonal thyroid balance in healthy children with no previous history of any thyroid diseases.Thirty eight children at age from 6 to12 years old with no personal and...

The endocrine active compound 4-methylbenzylidene-camphor (4-MBC) is frequently used as an UV absorber in sunscreens and various skin care products. Though 4-MBC is weakly estrogenic in the reproductive system of fishes and rodents it shows strong anti-osteoporotic effects. Furthermore, different studies show percutanous absorption of 4-MBC after dermal administration resulting in identical biotransformation in humans and rats. Female Sprague-Dawley rats received five concentr...

Vitamin A (retinol) plays a non-substitutable role in a process of growth and differentiation of tissues. Deficit of retinol can be encountered at its long-term diet deprivation (primary deficit), but it can occur also as a consequence of metabolism disorders on various levels (secondary deficit). Secondary deficit of retinol can occur also in people exposed to chemical substances in the long term or people living in an environment polluted by chemicals for a long time. One of...