Searchable abstracts of presentations at key conferences in endocrinology

ea0035oc3.1 | Neuroendocrinology & Signalling | ECE2014

Constant intravenous infusion of kisspeptin-54 restores LH pulsatility in women with hypothalamic amenorrhoea

Jayasena Channa , Abbara Ali , Comninos Alexander , Veldhuis Johannes , Nihjer Gurjinder , Ganiyu-Dada Zainab , Mehta Amrish , Todd Catriona , Ghatei Mohammad , Bloom Stephen , Dhillo Waljit

Background: Women with hypothalamic amenorrhoea (HA) have reduced LH pulsatility causing amenorrhea and infertility. Estrogen supplementation provides symptomatic relief for women with HA, but does not restore the pulsatile pattern of LH secretion which necessary for fertility. Kisspeptin-54 is a recently identified hormone, which potently stimulates GNRH secretion within the hypothalamus. The effect of exogenous kisspeptin-54 administration on LH pulsatility in women with HA ...