Searchable abstracts of presentations at key conferences in endocrinology

ea0014p332 | (1) | ECE2007

Gq/11-dependent signaling of the tyhrotropin receptor regulates metallothionein 1 expression in human thyroid carcinoma cells

Buech Thomas , Baeck Christer , Nowak Nicola , Gudermann Thomas

Metallothioneins (MT) are cystein-rich intracellular proteins which exert anti-apoptotic effects by protecting cells against oxidative stress and DNA damage. Previously, expression of MT in normal and neoplastic thyroid tissue has been demonstrated. However, the thyroidal regulation of MT expression is widely unsettled. Thus, we investigated the expression of MT isoform 1 in human thyroid carcinoma cells (FTC-133-TSHR) upon stimulation with thyrotropin (TSH). Using quantitativ...