Searchable abstracts of presentations at key conferences in endocrinology

ea0070ep35 | Adrenal and Cardiovascular Endocrinology | ECE2020

Mediastinal malgnant paraganglioma: An atypical presentation

Pinheiro Sara , Damasio Ines , Nunes da Silva Tiago , Leite Valeriano

Introduction: Mediastinal paragangliomas are rare. These tumours can be associated with increased morbidity and mortality when invasive growth to the heart, great vessels, esophagus and trachea occurs. Surgical resection, if feasible, is the treatment of choice.Case report: A 50-year-old man presented with severe and refractory left gluteal pain radiating to the posterior thigh for two months. The patient had no relevant medical history and no other symp...

ea0084ps1-03-27 | Thyroid Cancer CLINICAL 1 | ETA2022

Clinical significance and prognosis of solid / trabecular component areas of papillary thyroid carcinoma

Pinheiro Sara , Damasio Ines , Simoes-Pereira Joana , Nunes da Silva Tiago , Leite Valeriano

Introduction: the presence of areas with a solid / trabecular growth pattern in differentiated papillary thyroid carcinoma (PTC) represents a source of controversy regarding clinical and prognostic significance and usually requires a more aggressive therapeutic approach. The aim of this study was to compare clinicopathological characteristics, treatments and prognosis of PTC with and without solid component (SC). We also aimed to evaluate whether SC affects patient outcome in ...

ea0075a08 | Adrenal gland | EYES2021

Ectopic cushing’s syndrome secondary to acinic cell carcinoma of the parotida gland: A case-report

Pinheiro Sara , Filipe Juliana , Meireles Pedro , Castelo Branco Sara , Rito Miguel , Nunes da Silva Tiago

Background: Ectopic ACTH secretion from metastatic acinic cell carcinoma (ACC) of the parotid gland is extremely rare. ACC is an uncommon, typically indolent, salivary gland neoplasm. Herein, we report a case of a high-grade ACC later diagnosed with CushingÂ’s syndrome (CS).Case presentation: A 60-year-old man presented with a laterocervical mass. Computed tomography (CT) documented a 39×38 mm mass on the parotid gland and homolateral cervical l...

ea0092ps3-29-04 | Treatment 2 | ETA2023

Effectiveness of lenvatinib in progressive metastatic radioiodine refractory well differentiated and poorly differentiated thyroid carcinoma

Nunes da Silva Tiago , Regala Catarina , Rodrigues Ricardo , Roque Joao , Damasio Ines , Cavaco Branca , Leite Valeriano

Introduction and objectives: Lenvatinib is the first line treatment for advanced radioiodine refractory (RAIR) differentiated thyroid carcinoma (DTC). Poorly differentiated thyroid carcinoma (PDTC) outcomes with Lenvatinib have only been subjected to sub analysis in one PHASE III study (SELECT), which might limit its real-world use in PDTC. We intend to compare the effectiveness of Lenvatinib in metastatic RAIR DTC and PDTC patients.Methods: Retrospectiv...

ea0084op-03-16 | Oral Session 3: Advanced Thyroid Cancer | ETA2022

A clinical and molecular study of a real-world cohort of braf v600e anaplastic thyroid carcinoma treated with dabrafenib and trametinib

Nunes da Silva Tiago , Rodrigues Ricardo , Rito Miguel , Saramago Ana , Pires Carolina , Horta Mariana , Leite Valeriano , Cavaco Branca

Introduction and objectives: Anaplastic thyroid cancer (ATC) has a very low overall survival (OS) and progression free survival (PFS) due to fast growth and resistance to non-target therapies. A recent phase II study showed a dramatic increase in OS and PFS of BRAF V600E mutated ATC patients treated with Dabrafenib and Trametinib (DT). However as commonly reported in melanoma durable responses in ATC may be compromised by resistance mechanisms. Until now only a few ca...

ea0084ps3-14-132 | Thyroid Cancer CLINICAL 2 | ETA2022

Efficacy and safety of lenvatinib in a cohort of well-differentiated advanced thyroid carcinomas

Damasio Ines , Maciel Joana , Figueiredo Ana , Simoes Helder , Nunes da Silva Tiago , Simoes-Pereira Joana , Horta Mariana , Santos Rita , Donato Sara , Leite Valeriano

Introduction: Treatment of differentiated thyroid carcinoma (DTC) remains a challenge in the setting of locally advanced or metastatic disease refractory to radiodine (RAI) therapy. SELECT trial demonstrated that Lenvatinib improved progression free survival (PFS) comparing to placebo.Objective: Our aim is to report the efficacy and safety of lenvatinib in our population with aggressive DTC.Methods: We retrospectively reviewed the ...

ea0041ep31 | Adrenal cortex (to include Cushing's) | ECE2016

Primary aldosteronism – results from the first Portuguese multicentre study

Nunes da Silva Tiago , Fernandes Vera , Martins Diana , Goncalves Diana , Almeida Raquel , Margarida Monteiro Ana , Neves Carolina , Simoes Helder , Marques Pedro , Alves Filipa , Pereira Maria

Primary Aldosteronism (PA) is the most prevalent cause of secondary hypertension. The aim of this work was to characterize the diagnostic workup, treatment and follow-up of confirmed PA.The adrenal tumour study group of the Portuguese Society of Endocrinology undertook the first retrospective multicentre study of Portuguese PA patients. Data was gathered from nine Portuguese Endocrinology centres (three in the north, one in the centre and five in the sou...

ea0070aep29 | Adrenal and Cardiovascular Endocrinology | ECE2020

Treatment outcomes in 198 patients of the portuguese adrenocortical carcinoma register

Nunes da Silva Tiago , Catarino Diana , Paiva Isabel , Chaves Carolina , Costa Claudia , Castro Raquel , Paula Marques Ana , Souteiro Pedro , Pereira Maria , Machado Catarina , Belo Carlos , Simões Helder , Cortes Luisa , Pereira Bernardo , Anselmo João , Sapinho Inês , Gonçalves Ferreira Ana , Teresa Pereira Maria , Fonseca Liliana , Fernandes Isabel , Rita Elvas Ana , Donato Sara , Martins Anabela , Fajar Laura , Martinho Mariana , Garrido Susana , Ferreira Marta

Introduction: Adrenocortical carcinoma (ACC) is a rare entity, usually associated with a poor prognosis. There are still many areas of uncertainty regarding its approach.Methods: A Portuguese ACC register was established in 2020, including information from 24 endocrine centres. Kaplan-Meier was used to calculate overall survival and recurrence; log- rank test to assess survival and progression free survival (PFS) differences between groups; cox-regressio...