Endocrine Abstracts

Introduction: Thyroid isthmus has lack of normal parenchyma, and it connects both of thyroid lobes with lymphatic drainage. It is known that isthmic papillary thyroid cancer (PTC) presents frequent extrathyroidal extensions (ETE), multifocality and lymph node involvement. Therefore, many surgeons prefer total thyroidectomy and central compartment neck dissection (CCND) for the radical treatment of PTC located in thyroid isthmus. The purpose of this study is to figure out the c...

Objectives: Currently 131I treatment after surgery is suggested in selected intermediate-risk and in high-risk patients with DTC. In patients with radio-avid structural disease and in those with biochemical disease a second 131I treatment could be considered. However data about the impact of the second 131I treatment on clinical status remains controversial.Methods: Clinical data of 231 DTC patients followed at the Unit o...

Background: The last American Thyroid Association guidelines (ATA-2015) defined the risk of structural recurrence in patients with DTC cured after initial treatment and according to the initial histology. However, these data resulted from several studies including different patients with different kinds of treatment. We retrospectively evaluated a large population of patients with DTC, treated and followed in a tertiary referral center, with the aim to characterize the rate of...

Background: Since 2006 according to the European consensus for the management of patients with DTC, in tumors ≤ 1 cm, treatment with thyroidectomy alone without 131I treatment was suggested. Therefore, in our institution, we applied this suggestion in clinical practice, although prospective studies were not still available. Aim of this study is to evaluate the rate of the events occurring in a medium-long term follow-up.Patients and Meth...

Background: The presence of extathyroidal extension (ETE) is associated with locoregional recurrence and distant metastases in papillary thyroid carcinoma (PTC). ETE is classified into gross ETE (gETE) and minimal ETE (mETE). The mETE was recently excluded from the T3 category in the TNM staging system. The purpose of this study is to compare the recurrence risk of mETE and gETE in PTC patients through propensity score matching analysis. And a comparison in the same way for pa...

Background: To date, no staging system has been related to the number of metastatic lymph node or lymph node ratio. Lymph node ratio (LNR) was defined as the number of metastatic LNs divided by the total number of LNs dissected. The purpose of this study was to determine how central LNR had a prognostic value to predict recurrence in N1b papillary cancer.Methods: This study included 331 patients who underwent total thyroidectomy with lateral neck dissect...

Objectives: Evaluate the benefit of postsurgical radioactive iodine (RAI) in patients with differentiated thyroid cancer (DTC) at low to intermediate risk of recurrent disease in whom not routinary use of RAI is recommendedMethods: We retrospectively evaluated 1316 patients with DTC diagnosed between 2009-2015. ATA low (LR) and intermediate (IR) risk were included in the study (PTC: tumor size > 1 cm, microscopic extrathyroidal invasion, <5 micro...

Background and Aim: American Thyroid Association (ATA) guidelines do not consider age at diagnosis of differentiated thyroid cancer (DTC) as a prognostic factor in the estimation of risk of recurrence and persistent disease. While age at diagnosis has already been assessed in high-risk patients, it remains to be established whether there is a correlation between age at diagnosis and long term outcome in DTC patients.Methods: We retrospectively evaluated ...

Introduction: the presence of areas with a solid / trabecular growth pattern in differentiated papillary thyroid carcinoma (PTC) represents a source of controversy regarding clinical and prognostic significance and usually requires a more aggressive therapeutic approach. The aim of this study was to compare clinicopathological characteristics, treatments and prognosis of PTC with and without solid component (SC). We also aimed to evaluate whether SC affects patient outcome in ...

Objectives: Cardiovascular disease encountered the leading cause of death in thyroid cancer survivals exceeding death by cancer itself. Etiological factors are the therapy used and the duration of exposure to this it, the diagnosis of cancer itself, or the factors that led to this cancer. We aim to evaluate cardiometabolic risk factors in an Algerian cohort of thyroid cancer survivals.Methods: The study includes a cohort of patients followed in the thyro...