Endocrine Abstracts

Objective: To study the life quality of patients with subclinical hypothyroidism by using questionnaire SF-36 before and after replacement therapy.Methods: All patients were collected at the Department of Endocrinology 3rd clinics of Tashkent Medical Academy. The study included 55 women with subclinical hypothyroidism and 20 women for the control group. The age surveyed had an average of 37,6 ± 8,83 years. Patients included in the study do not take re...

Background: Hypothyroidism is a clinical condition caused by a deficiency of thyroid hormones or a decrease in their biological activity. Premature ventricular contractions (PVCs) are early depolarizations of the myocardium originating in the ventricles. Rhythms with frequent and apparently idiopathic PVCs are considered to be a benign condition that can be managed with conservative measures. Beta blockers are considered to be quite effective.Objective: ...

Objectives: Some hypothyroid patients are critical of their care, although this appears to vary between countries. The quality of thyroid care delivered, and the perceived patient experience may be influenced by characteristics of specialists such as age, sex, experience, and workplace setting. Here, we aimed to explore geographical differences in thyroid specialist characteristics.Methods: THESIS is a large European questionnaire survey of thyroid speci...

Introduction and Aim: Obesity is associated with an increased risk of hypothyroidism and chronic autoimmune thyroiditis (AIT). However, little is known about the underlying pathogenic mechanisms. Recently it has been evaluated the role played by sex hormones in the onset of AIT and, analysing the data from a large cohort of normal/overweight males, a positive correlation between an increased ratio of estradiol/testosterone levels (E2/T) and AIT was found. Since obese males are...

Introduction: Congenital hypothiroidism (CH) is the most common neonatal endocrine disorder, affecting up to one in 1500 to 2000 newborns, if mild forms of hypothyroidism with eutopic and normal-sized thyroid gland are included. It is caused by either dysgenesis or dyshormonogenesis. Recently a novel iodide transporter, SLC26A7 (a member of the SLC26 transporter family), whose dysfunction affects thyroid hormonogenesis in humans, has been identified. The main purpose of this s...

Introduction: Congenital hypothyroidism (CH) with in situ thyroid gland (GIS) and non-autoimmune subclinical hypothyroidism (NASI) are functional defects of thyroid gland occurring at birth and after birth, respectively. In recent years, a higher incidence of these disorders has been documented. The etiology remains unclear, with only an almost 50% of cases attributable to mutations in known dyshormonogenesis-associated or TSH-receptor genes. Although replacement ther...

Background: In recent years, increasing cases of congenital hypothyroidism (CH) with in situ thyroid gland (GIS) are identified. Outcome of children affected from CH with normally sited thyroid of normal size is still unknown. The objective of our study is to describe the natural history of this specific form of CH.Methods: We retrospectively evaluated clinical, biochemical and instrumental data of 89 patients with diagnosis of CH and GIS, refer...

Isolated hypothyroxinemia is rarely and briefly mentioned in medical textbooks and seldom discussed at endocrine conferences. It is most often, but not exclusively encountered in pregnancy. The author presents cases of isolated hypothyroxinemia encountered at a private endocrine practice in Budapest, Hungary and a specialized medical practice in Berlin, Germany. In the last seven years the author encountered about thirty cases: app. 60% in women who were 17-85 years old and ap...

Thyroid hormones (TH) play a fundamental role in brain development. Changes on TH availability during pregnancy and early childhood can lead to neurological disorders. Accordingly, concerns are mounting that exposure to environmental compounds capable of interfering with TH action can disrupt neuronal development. Current approaches to categorize chemicals as thyroid hormone system disrupting chemicals (THSDC) are mainly based on determination of changes in circulating TH conc...