Searchable abstracts of presentations at key conferences in endocrinology

ea0029p431 | Clinical case reports - Thyroid/Others | ICEECE2012

Impact of glibenclamide therapy in a patient with neonatal diabetes and intermediate DEND syndrome with the V59M mutation in the KCNJ11 gene

Giestas A. , Borges T. , Oliveira M. , Guimaraes A. , Cardoso H.

Introduction: Neonatal diabetes is a rare condition diagnosed within the first months of life. Activating mutation of KCNJ11, the gene encoding the Ki6.2 subunit of the ATP-sensitive potassium channel, is the most common cause of permanent neonatal diabetes, and ~20% of patients have neurological features.Patients with the severe neurological phenotype exhibit developmental delay, motor weakness, and epilepsy in addition to diabetes (DEND syndrome). Inte...

ea0029p873 | Endocrine tumours and neoplasia | ICEECE2012

Hypoglycemia by insulinoma: for the purposes of a case

Jorge G. , Nogueira C. , Esteves C. , Neves C. , Queiros J. , Oliveira M. , Pardal J. , Carvalho D.

Clinical caseIntroduction: Insulinoma is a rare disorder with an estimated incidence of 1 case per 250 000 people per year.Case report: 37 years old female, with a history of irritable bowel syndrome, dyslipidemia and kidney stones. In December 2010, she developed a headache, dizziness and visual disturbances, predominantly in the evening and amnesia for some of the episodes. Initially interpreted as peripheral vertiginous syndrome, because of recurrence...

ea0026p488 | Thyroid cancer | ECE2011

Radiodine therapy and age at menopause in women with differentiated thyroid cancer

Martins T , Azevedo T , Martinho M , Oliveira S , Neto J , Rodrigues F

Introduction: Radiodine (131I) is widely used in the treatment of patients with thyroid cancer. This therapy is associated with some adverse effects including possible impairment of ovarian function and earlier menopause.Objective: The aim of this study was to evaluate female fertility after treatment with 131I of differentiated thyroid cancer (DTC).Methods: We retrospectively analysed 250 women with DTC treat...

ea0002p56 | Growth and development | SFE2001

Does the adverse lipid profile in humans with severe GHD worsen from childhood to adult life?

Gleeson H , Gill M , Wieringa G , Aguiar-Oliveira M , Shalet S , Clayton P

Growth hormone deficiency (GHD) is associated with adverse changes in lipid profile. There are no longitudinal studies of lipid abnormalities in childhood-onset GHD into adulthood. In order to more accurately define the metabolic consequences of GHD in childhood progressing through to adulthood we have examined lipid levels in a group of untreated severely GHD patients with a mutation in the GHRH receptor gene from a rural community in Northeast Brazil.1...

ea0011p170 | Clinical case reports | ECE2006

Cushing’s syndrome due to medullary thyroid carcinoma – a case report

Sousa A , Rodrigues E , Varela A , Vinha E , Braga D , Couto P , Lopes J , Cardoso-Oliveira M , Medina JL

Ectopic ACTH secretion due to malignant tumours is a rare cause of hypercortisolism. Induced metabolic disturbances are often serious and the management of such patients may be difficult. We report the case of a 50-yr-old man who had a sporadic medullary thyroid carcinoma (MTC) removed 2 years ago (Dec/2003). Calcitonin and CEA levels remained high postoperatively and a CT scan revealed liver metastases. In August 2005 he was referred to Endocrinology with symptoms of muscular...