Searchable abstracts of presentations at key conferences in endocrinology

ea0010s10 | Non classical sites of action of classical hormones | SFE2005

Direct actions of pituitary hormones on bone

Zaidi M , Sun L , Onigata K , Abe E

We have revisited the actions of hormones from the anterior pituitary, notably TSH, on bone and bone cells. Traditionally, the bone loss in hyperthyroidism has been attributed solely to elevated circulating levels of thyroid hormones. The role of TSH, which is reduced in all forms of hyperthyroidism, as well as during thyroxine suppressive therapy for thyroid cancer, has never been investigated. We found that haploinsufficiency of the TSH receptor in mice led to bone loss with...