Searchable abstracts of presentations at key conferences in endocrinology

ea0020p630 | Reproduction | ECE2009

Free thiols in human spermatozoa: correlation with Na+/K+-ATPase, Ca2+-ATPase activities and sperm motility

Vignini Arianna , Buldreghini Eddi , Nanetti Laura , Raffaelli Francesca , Paggi Francesca , Boscaro Marco , Mazzanti Laura , Balercia Giancarlo

The aim of the present study was to measure free thiols content, Na+/K+-ATPase, Ca2+-ATPase activities in human spermatozoa of asthenozoospermic patients and normospermic donors, and evaluate any influence on kinetic sperm features, as well as correlation with peroxynitrite. In fact, membrane integrity and its composition are the basic characteristics of the sperm membrane, thus, it is evident that its composition is an important factor for mem...

ea0016p650 | Reproduction | ECE2008

Reactive nitrogen species in the chemical biology of sperm functions

Vignini Arianna , Bildreghini Eddi , Nanetti Laura , Raffaelli Francesca , Paggi Francesca , Mazzanti Laura , Mantero Franco , Boscaro Marco , Balercia Giancarlo

Inflammation activates a variety of inflammatory cells, which induce and activate several oxidant-generating enzymes which are able to produce high concentrations of free radicals and oxidants which react with each other to generate other more potent reactive oxygen and nitrogen species such as peroxynitrite (ONOO−) that can damage DNA, RNA, lipids, and proteins by nitration, oxidation, etc., leading to increased mutations and altered functions of enzymes and ...

ea0022p536 | Male reproduction | ECE2010

Sexual dysfunctions in subjects with Klinefelter's syndrome

Corona Giovanni , Petrone Luisa , Paggi Francesca , Lotti Francesco , Boddi Valentina , Fisher Alessandra , Vignozzi Linda , Balercia Giancarlo , Sforza Alessandra , Forti Gianni , Mannucci Edoardo , Maggi Mario

Introduction: While the association of Klinefelter’s syndrome (KS) with infertility is well known, very few investigations have evaluated the prevalence of sexual dysfunction in KS. The aim of the present study is to systematically analyse the prevalence of KS in a consecutive series of adult male patients consulting for sexual problems and to investigate its specific correlates.Methods: Among a consecutive series of 1386 patients (mean age 48.9&#17...