Searchable abstracts of presentations at key conferences in endocrinology

ea0055p39 | Poster Presentations | SFEEU2018

Management of acromegaly in pregnancy and post-partum

Saeed Tamar , Jafar-Mohammadi Bahram , May Christine , Pal Aparna

Case history: A 39 year old female presented reporting a 5-year history of swollen face, hands and feet, with associated joint pain. She was initially investigated for rheumatoid arthritis. She had no significant past medical history except for a previous miscarriage in 2014 and treatment for hypertension in a subsequent successful pregnancy. Post-partum she breastfed with no difficulty for 18-months but remained amenorrhoeic during this time. During 2016 she noticed increase ...

ea0055p43 | Poster Presentations | SFEEU2018

SDH mutation and prolactinomas: case series

Timms Richard , May Christine , Pal Aparna , Jafar-Mohammadi Bahram

Succinate dehydrogenase (SDH) mitochondrial enzyme complex mutations are associated with hereditary paragangliomas and phaeochromocytomas. Of late, there has been more awareness of the development of other tumours in this patient cohort. There is limited evidence of propensity for development of Prolactinomas and other pituitary tumours in patients harbouring mutations in the SDH complex genes. We present three cases attending our center with a diagnosis of prolactinoma and <e...

ea0081ep10 | Adrenal and Cardiovascular Endocrinology | ECE2022

A case of ChAdOx1 vaccine-induced thrombocytopaenia and thrombosis syndrome leading to bilateral adrenal haemorrhage and adrenal insufficiency

Efthymiadis Agathoklis , Khan Dalia , Pavord Sue , Pal Aparna

Introduction: Vaccine-induced thrombosis and thrombocytopenia (VITT) after vaccination against SARS-CoV-2 with the adenoviral vector-based vaccines ChAdOx1 and Ad26.COV2.S has been associated with adrenal pathology, such as bilateral adrenal vein thrombosis, adrenal cortex haemorrhage and adrenal insufficiency in six percent of patients1.Case report: We report the case of a 23-year-old healthy woman who presented at eight days after ChAdOx1 va...

ea0082oc9 | Oral Communications | SFEEU2022

A case of ChAdOx1 vaccine-induced thrombocytopenia and thrombosis syndrome leading to bilateral adrenal haemorrhage and adrenal insufficiency

Efthymiadis Agathoklis , Khan Dalia , Pavord Sue , Pal Aparna

Case History: We report the case of a 23-year-old woman who developed adrenal insufficiency secondary to bilateral adrenal haemorrhage in the context of vaccine-induced thrombosis and thrombocytopenia (VITT). She presented with breathlessness and chest pain eight days after receiving her first dose of the adenoviral vector-based ChAdOx1 vaccine. Over the course of a week, she developed fulminant VITT. Her only comorbidity was obesity, with BMI of 35 kg/m2. <p class="abstex...

ea0048cp10 | Poster Presentations | SFEEU2017

Bladder paraganglioma presenting in pregnancy as an incidental mass on a first trimester scan

Navaneetham Nanthakrishna , Mackillop Lucy , Greenwood Catherine , Pal Aparna

Case history: This 32-year-old lady was found to have a 23 × 17 mm bladder mass incidentally identified on a first trimester scan and confirmed with renal tract ultrasound. Urine collections showed mildly raised normetadrenaline 4.32 umol/24 h (normal range 0–3.0), plasma normetanephrine 1339 pmol/l (120–1180), no metastases were identified on MRI and genetic screening was negative. The patient had two previous normal pregnancies and deliveries. BP in the curren...

ea0059ep93 | Reproduction | SFEBES2018

The challenge of diagnosing 5-alpha-reductase deficiency post gonadectomy

Miles Stephanie , Shears Deborah , Shine Brian , Grossman Ashley , Pal Aparna

A 35 year old woman was referred to Endocrinology after imaging investigating unexplained pyrexia demonstrated an absent uterus. She was of Pakistani origin and was born phenotypically female with reported normal female genitalia. During late teenage years she experienced virilisation with deepening voice, increased pubic and axillary hair and clitoromegaly. She had absent breast development. Her parents were first cousins and siblings were unaffected. Investigations in Pakist...

ea0013p76 | Clinical practice/governance and case reports | SFEBES2007

Acute falciparum malaria and parathyroid function

Pal Aparna , Karavitaki Niki , Wass John , Simpson Hugh

We present a rare case of acute falciparum malaria complicated by hypocalcaemia while having normal renal function.Case: A 64 year old African lady presented with a 2 week history of lethargy, weakness and oliguria. She had returned from Malawi a fortnight previously and had not taken antimalarial prophylaxis. Her malaria screen was positive for Plasmodium falciparum and she was commenced on quinine. On day 5 of her admission she developed perioral pares...

ea0086cc2 | Featured Clinical Case Posters | SFEBES2022

Coexistence of cranial diabetes insipidous and heart failure with reduced ejection fraction: a case report presenting challenges and unique therapeutic opportunities

Efthymiadis Agathoklis , H P Gamble James , Pal Aparna

History: We present the case of a 47-year-old man with heart failure (HF) and cranial diabetes insipidus (CDI) secondary to Langerhans-cell-histiocytosis. In the context of worsening HF with increasing shortness of breath and fluid retention, careful desmopressin dose reduction provided adequate aquaresis to restore euvolemia, obviating the need for usual diuretic treatments.Investigations: Echocardiography and a cardiac MRI revealed a non-dilated but se...

ea0078p58 | Pituitary and Growth | BSPED2021

Management of cranial Diabetes Insipidus in a paediatric tertiary centre – clinical outcomes and patient perception of care

Garrahy Aoife , Dilrukshi MDSA , Vickars Marcus , Pal Aparna , Ryan Fiona , Makaya Taffy

There is growing recognition within Endocrinology physician and patient groups of morbidity and mortality in association with prescribing errors and dysnatraemia, in hospitalised patients with cranial diabetes insipidus (CDI). The study had two aims; firstly, to assess outcomes in hospitalised patients (paediatric and adult) with CDI by review of electronic records from 2012-2021, and secondly, to assess the same patient cohort’s perceptions of their care via telephone qu...

ea0081p21 | Adrenal and Cardiovascular Endocrinology | ECE2022

Time from referral to definitive treatment in Cushing’s syndrome

Coulden Amy , Aylwin Simon , Flanagan Daniel , Mamoojee Yaasir , Pal Aparna , Gittoes Neil , Gleeson Helena

Rapid diagnosis and treatment of Cushing’s syndrome (CS) is essential for good outcomes. Current standards for appropriate timelines for referral are under review by NHSE. Data are required to substantiate standard setting. Knowledge of current referral pathways/processes are required to explore delays in accessing definitive surgical treatment. An audit of referral processes at Queen Elizabeth Hospital Birmingham was undertaken and further expanded to 4 additional tertia...