Searchable abstracts of presentations at key conferences in endocrinology

ea0070aep671 | Pituitary and Neuroendocrinology | ECE2020

To score or not to score? Is Ki-67 analysis worthwhile in pituitary neuroendocrine tumours?

Benjamin Loughrey Paul , Craig Stephanie , Herron Brian , Abdullahi Sidi Fatima , McQuaid Stephen , Kelly Paul , Humphries Matt , Parkes Eileen , McArt Darragh , Hunter Steven , Korbonits Marta , James Jacqueline

Pituitary neuroendocrine tumours (PitNETs) are heterogeneous and have limited biomarkers to predict their behaviour, thus making their prognostication difficult. Ki-67 is a protein expressed in active phases of the cell cycle and is one of the biomarkers utilized in routine assessment of PitNET tissue. Current European Society of Endocrinology recommendations advise that histopathological analysis of PitNETs should as a minimum include Ki-67 proliferation index and anterior pi...

ea0073aep488 | Pituitary and Neuroendocrinology | ECE2021

Pituitary surgery in northern ireland: A twenty year retrospective population based analysis

Loughrey Paul Benjamin , Craig Stephanie , Herron Brian , Cooke Stephen , Weir Philip , Bhattacharya Debarata , Sturdy Erin , Salto-Tellez Manuel , Parkes Eileen , McArt Darragh , Korbonits Marta , Hunter Steven , James Jacqueline

In Northern Ireland, the sole tertiary referral centre for pituitary disease which includes neurosurgery and endocrinology for ~1.9 million people, is based in the Royal Victoria Hospital, Belfast. A retrospective study has been commenced to examine clinical, biochemical, histopathological and radiological data for all patients operated on across an approximately 20 year period in Northern Ireland. Ethical approval was obtained from the Northern Ireland Biobank (study num...

ea0077oc2.5 | Endocrine Cancer and Late Effects | SFEBES2021

A novel MiR-346-Directed DNA damage mechanism is regulated by its interaction with long non-coding RNA, NORAD, in prostate cancer

Fletcher Claire , Orafidiya Folake , Deng Lin , Yuan Wei , Lorentzen Marc , Cyran Oliwia , Varela-Carver Anabel , Constantin Theodora , Dobbs Felix , Figueiredo Ines , Gurel Bora , Parkes Eileen , Bogdan Denisa , Pereira Ronnie , Zhao Shuang (George) , Neeb Antje , Issa Fadi , Hester Joanna , Kudo Hiromi , Liu Yang , Philippou Yiannis , Bristow Robert , Knudsen Karen , Bryant Richard , Feng Felix , Reed Simon , Mills Ian , de Bono Johann , Bevan Charlotte

MiR-346 is an Androgen Receptor (AR)-activating miR that associates with DNA damage response (DDR)-linked transcripts in prostate cancer (PC). MiR-346 induces rapid and extensive DNA damage in PC cells through chromatin association, activation of transcription, R-loop formation and DNA replication stress, leading to checkpoint activation and cell cycle arrest. MiR-346 interacts with lncRNA, NORAD, in PC cells, which functions to maintain mitosis, DDR, and chromosomal integrity...