Endocrine Abstracts

PYY is secreted postprandially from the endocrine L-cells of the gastrointestinal tract. PYY3–36, the major circulating form of PYY, reduces food intake in humans and rodents via high affinity binding to the auto-inhibitory NPY receptor, Y2R, within the hypothalamic arcuate nucleus.Aims: To investigate (1) the effects of length of fast on the anorexigenic actions of PYY3–36; (2) the effects of early light phase administrat...

Introduction: Due to the increasing prevalence of childhood obesity, and challenges presented by associated physical and psychological comorbidities, NHS England initiated a pilot to treat Complications from Excess Weight (CEW) in dedicated clinics across the country. Facilitating sufficient face-to-face appointments with increased need for services carries associated costs and greater demand, both on the patient and their families, and on the medical team. To supplement the r...

The rise in the prevalence of obesity has imparted urgency to the study of the mechanisms of appetite regulation. Oxyntomodulin (OXM) and glucagon-like peptide-1 (GLP-1) are anorexigenic gut hormones thought to act via the same receptor. There is an increasing body of evidence, however, that they may act via distinct pathways. Magnetic resonance imaging (MRI) is increasingly being used as a tool for tracking changes in neuronal activity in vivo through time. Manganese-e...

Background: Children and young people (CYP) living with obesity are at increased risk of developing various physical and mental health comorbidities. Multidisciplinary (MDT) approach for the early detection and management of comorbidities is important. We report the outcomes of the first 100 patients enrolled in the tier-3 MDT Complications from Excess Weight (CEW) service.Methods: 100 new CYP (F=53) enrolled in the CEW service from March 2022-February 2...