Searchable abstracts of presentations at key conferences in endocrinology

ea0035p986 | Thyroid (non-cancer) | ECE2014

Polymorphisms within genes encoding co-stimulatory molecules modulate the susceptibility to Graves' disease and orbitopathy

Daroszewski Jacek , Pawlak-Adamska Edyta , Przemyslaw Janusz , Frydecka Irena , Karabon Lidia , Jonkisz Anna , Tomkiewicz Anna , Partyka Anna , Lebioda Arleta , Bolanowski Marek

The clinical presentation of GravesÂ’ disease (GD) depends on the combination of environmental and genetic factors. The CTLA-4 and CD28, ICOS genes encoding negative and positive regulator of the T-lymphocyte immune response, are candidate genes for conferring susceptibility to thyroid autoimmunity.Polymorphisms in genes: CTLA-4: g.319C>T (rs5742909), c.49A>G (rs231775), g.*642AT(8_33), CT60 (g.*6230G>A, rs3087243), Jo31...