Searchable abstracts of presentations at key conferences in endocrinology

ea0055oc4 | National Clinical Cases | SFEEU2018

Management of massive (up to 550 mm) bilateral adrenal masses in a non-adherent patient with 21-hydroxylase deficiency congenital adrenal hyperplasia:complex risk benefit analysis

Waterhouse Jasmin , Parvanta Laila , Akker Scott , Berney Dan , Lawrence Victor

Case history: We report a 38 year-old Caucasian woman with classical salt wasting congenital adrenal hyperplasia (CAH) who increasingly omitted medication in adolescence and eventually spent over 10 years without any adrenal replacement therapy or adrenal crises and became lost to follow up. When seen, she complained of increasing abdominal girth, fatigue, hirsutism, had type 2 diabetes, had never had a romantic/sexual relationship and was amenorrhoeic. Examination revealed ab...

ea0055we8 | Workshop E: Disorders of the adrenal gland | SFEEU2018

A pressing diagnosis in an adolescent

O'Toole Sam , Tufton Nicola , Arnez Lorena , Parvanta Laila , Akker Scott

Case history: A 17 year old previously healthy male presented to his local emergency department with a generalised tonic seizure associated with severe hypertension (systolic blood pressure 240 mmHg) and tachycardia. He was intubated and admitted to the Intensive Care Unit. Antimicrobials to cover meningoencephalitis were commenced and his hypertension was managed with intravenous labetalol. He was extubated the following day. He had experienced headaches on a monthly basis fo...

ea0028p112 | Clinical practice/governance and case reports | SFEBES2012

Intrathyroidal parathyroid carcinoma: Putting the pieces together

Sivarajah Vernon , Anderson John , Berney Dan , Parvanta Laila

Parathyroid carcinoma (PTC) is a rare condition that lacks pathognomonic features, making diagnosis and therefore management challenging. In the very few cases of intra-thyroidal PTC reported, failure to achieve a pre-operative diagnosis has often led to unnecessary bilateral neck exploration and re-operation. We describe for the first time a case of intra-thyroidal PTC suspected pre-operatively. A 37-year-old Bangladeshi man presented with a 3-week history of mood changes, mu...

ea0015p80 | Clinical practice/governance and case reports | SFEBES2008

An unusually large thyroglossal cyst harbouring a papillary thyroid cancer

Parvanta Laila , Berney Dan , Richards Polly , Akker Scott , Carpenter Robert

A 24-year-old girl was referred with a massive thyroglossal duct cyst (TGDC) and an intra-cystic papillary thyroid cancer (PTC). The impressive clinical photographs, striking radiological images and histology slides are presented.She presented eight and half months post partum with a 10 cm midline neck lump of 4 years duration. She was asymptomatic and was on levothyroxine for Hashimoto’s thyroiditis.Clinically, there was a cy...

ea0070ep542 | Hot topics (including COVID-19) | ECE2020

COVID-19 infection in a patient with life-treatening hypercalcaemia and sickle cell disease

Seguna Desiree , Marshall Henry , Barroso Filipa , Parvanta Laila , Adams Ashok , Berney Daniel , Akker Scott , Cavlan Dominic

A 21-year-old woman with homozygous sickle cell disease, presented to A&E with vomiting and diarrhoea, and was noted to be hypercalcaemic (corrected calcium 3.00 mmol/l [ref. 2.2–2.6]; phosphate 0.48 mmol/l [ref. 0.8–1.5]). She reported polyuria and polydipsia, but no other symptoms of hypercalcaemia. There was no history of renal stones, renal impairment, or fragility fracture. A maternal aunt required parathyroidectomy in middle age. Bloods revealed PTH 138.4 pmo...

ea0074oc7 | Oral Communications | SFENCC2021

Fulminant cushing’s crisis immediately post-partum – challenges of management

Milln Jack , Shepherd Stephen , Hameeduddin Ayshea , Berney Daniel , Parvanta Laila , Akker Scott

Case history/Investigations/Results and treatment: A previously healthy 36 year old female was admitted to a local intensive care unit with psychosis and intractable hypokalaemia. She had delivered a live preterm baby girl at 33 weeks gestation ten days previously. The hypokalaemia led to an endocrine consultation which revealed onset of symptoms in the third trimester, with no symptoms present pre-conception. Serum cortisol was 2,258 nmol/l with a nadir K+ of 2.2 mmol/l. She ...

ea0044ep30 | (1) | SFEBES2016

Hypercalcaemia induced psychosis due to primary hyperparathyroidism in pregnancy

Thomas Alice , Gunganah Kirun , Rayanagoudar Girish , Williams Eliot , Hanson Philippa , Drake Williams , Berney Daniel , Parvanta Laila , Kirwin Simon , Metcalfe Karl

Background: Primary hyperparathyroidism is the third most common endocrine condition in pregnancy after thyroid disease and diabetes. Untreated hypercalcaemia due to primary hyperparathyroidism increases the risk of miscarriage, intrauterine death and preterm labour. Pharmacological and surgical limitations in pregnancy often make diagnosing and managing this condition challenging. We report a complex case of hypercalcaemia-induced -psychosis due to primary hyperparathyroidism...

ea0094p175 | Adrenal and Cardiovascular | SFEBES2023

Laparoscopic adrenalectomy for phaeochromocytoma in the context of acute coronary syndrome

Soruna Omolayo , Plowman Christina , Yu Thinn , Pittaway James , Goodchild Emily , Wragg Andrew , Fitchat Tracey , Parvanta Laila , Akker Scott

A 54-year-old man presented to the heart attack centre with cardiac chest pain, vomiting and collapse. Biochemistry (troponin incremented from 117 to 315ng/l) and electrocardiogram confirmed a diagnosis of non-ST elevation myocardial infarction (NSTEMI). Past medical history included type 2 diabetes mellitus and hypertension (diagnosed 8 years previously), hypercholesterolaemia and a 20 pack year smoking history. Secondary prevention for MI was commenced and coronary angiograp...

ea0077p142 | Adrenal and Cardiovascular | SFEBES2021

Clinical prediction scores in primary aldosteronism reliably identify a subset of patients with bilateral disease avoiding the need for adrenal venous sampling

Munro Colin , Akker Scott , Druce Maralyn , Sze Wing-Chiu , Waterhouse Mona , Sahdev Anju , Matson Matthew , Parvanta Laila , Drake William , O’Toole Sam

Introduction: Primary aldosteronism (PA) is both the most common form of secondary hypertension and a high-risk subset associated with increased cardiovascular, cerebrovascular and renal morbidity compared to essential hypertension. Unilateral PA is amenable to surgery, biochemical cure and reversal of this excess risk; whilst bilateral disease is best treated through mechanism-directed medical therapy. Currently, PA subtype classification relies on adrenal venous sampling (AV...

ea0065p144 | Endocrine Neoplasia and Endocrine Consequences of Living with and Beyond Cancer | SFEBES2019

The yield and cost of radiological screening in von Hippel–Lindau disease

McMillan Timothy , Sahdev Anju , Evanson Jane , McAndrew Lorraine , Martin Lee , Paraskevopoulos Dimitrios , Bull Jonathan , Parvanta Laila , Gevers Evelien , Drake William , O'Toole Samuel

Introduction: Patients with the familial cancer syndrome von Hippel–Lindau disease (VHL) are enrolled in radiological screening programmes which aim to identify tumour development at an early stage. This facilitates timely intervention to lesions when the risk of metastatic spread is low and when they are conducive to less-invasive and parenchymal-sparing interventions, thereby minimising treatment-related morbidity. A number of international screening protocols exist, al...