Endocrine Abstracts

Thyroid hormone action, widely recognized on cell proliferation and metabolism, has recently been related to the phosphoinositide 3 kinase (PI3K), an upstream regulator of the Akt kinase and the involvement of the thyroid hormone receptor β1 has been hypothesized. The serine-threonine kinase Akt can regulate various substrates that drive cell mass, proliferation and survival. Its action has also been characterized in pancreatic β-cells. We previously demonstrated tha...