Endocrine Abstracts

Introduction: Acromegaly is a rare disorder and sporadic cases are the most frequent. It can also occur in association with genetic syndromes, such as Carney complex, multiple endocrine neoplasia type 1 (MEN-1), MEN-1 like syndrome, isolated familial acromegaly and familial isolated pituitary adenomas.Case report: Thirty five -year-old man was observed in 1994 for gynecomastia. Acromegaly was diagnosed based on clinical, biochemical (IGF1 1094.7 ng/ml, b...

Introduction: Medullary thyroid cancer (MTC), in its familial forms, is usually associated with pheochromocytoma and primary hyperparathyroidism, related to an underlying germline RET mutation. SDHx germline mutations associated with MTC have not yet been reported.Case report: We report the case of a 60-years-old woman, who was submitted, elsewhere, in November/2013, to a total thyroidectomy+right lymph-node dissection due to a nodule s...

Background: The adrenal incidentalomas (AI), adrenal masses ≥10 mm in diameter incidentally detected, have increased their prevalence due to technological advances in imaging. The adrenalectomy is indicated in functioning adrenal tumors and in cases suspected of malignancy.Objectives: To analyze the characteristics of patients with AI and to evaluate the clinical outcome, in terms of evolution toward hypersecretion and significant growth, during fo...

Introduction: Pituitary adenomas are frequent brain tumors, with prevalence of about 1:1000. Most occur sporadically. The familial forms represent 5% of cases. These can be found associated with other endocrine neoplasia (MEN 1, Carney complex, MEN 4) or as a clinical isolated entity – FIPA. This is characterized by the presence of pituitary tumors in two or more family members, in the absence of features of other endocrine syndromes. AIP gene mutation, which may or may n...

Background: Hypopituitarism after cranial radiotherapy for non-pituitary tumors is well recognized. However structured endocrine assessments are not incorporated into routine clinical practiceAim of the study: To evaluate pituitary function in adult patients irradiated for non-pituitary tumors at our centerPatients and Methods: Cross-sectional evaluation of pituitary function of all available patients treated with irradiation at ou...

Background: Apart from signs of hyperprolactinaemia, patients with macroadenomas with extrasellar extension generally seek medical attention due to mass effect. Macroprolactinomas, particularly in men, may occasionally exhibit a very aggressive clinical course.Case report: Male 37 years old that went to a Neurology consultation complaining of progressively more frequent self-limiting episodes of restraint, silence and time and space disorientation in the...

Introduction: The highly active antiretroviral therapy (HAART) completely changed the natural history and body composition of the infected patients. The lipodystrophy syndrome of HIV-infected patients (IP) is characterized by fat mass redistribution in the limbs, face lipoatrophy and abdominal lipohypertrophy. Dual-energy x-ray absorptiometry scan (DEXA) and bioelectrical impedance (BIA) are techniques to determine body composition (BC).Aims: Evaluate th...