Searchable abstracts of presentations at key conferences in endocrinology

ea0005p241 | Steroids | BES2003

Urinary steroid hormone metabolites in patients with porphyrias

Christakoudi S , Deacon A , Peters T , Taylor N

Patients with acute intermittent porphyria (AIP) but not those with porphyria cutanea tarda (PCT) have a reported predominance in urine of 5 beta-reduced androgen metabolites over 5 alpha epimers. Steroids of 5 beta- androstane and pregnane types induce delta-aminolevulinic acid (ALA) synthase in chick embryos in vitro, so altered 5-reduction may predispose to attacks. We have comprehensively examined urine androgen and cortisol metabolites by gas-liquid chromatography and uri...

ea0066p82 | Thyroid | BSPED2019

Siblings with multinodular goiter and autoimmune thyroiditis

Sotiridou Ellada , Kurzawinski T , Peters Catherine , Brain Caroline

Introduction: It has been documented that autoimmune thyroiditis (AT) predisposes to the development of papillary thyroid cancer (PTC). The presence of chronic inflammation was thought to act as an initiating factor in carcinogenesis. Moreover elevated levels of TSH found in hypothyroid patients with AT were speculated to stimulate follicular epithelial proliferation and thereby promote the development of PCT.Case: We describe a case of two sisters aged ...

ea0007p229 | Thyroid | BES2004

Twenty-four hour hormone profiles of TSH, free T3 and free T4 in hypothyroid patients on combined T3/T4 therapy

Siddique H , Saravanan P , Simmons D , Greenwood R , Peters T , Dayan C

Objective: To determine the 24hour thyroid hormone profile on patients with combined T3/T4 therapy.Methods: Two subgroup of patients (10 on combined T3/T4 (study, S) and 10 T4 alone (control, C) were randomly selected from 697 patients who were already involved in WATTS study, after ethical approval. Prior to study entry all patients were on 100micrograms or more of T4. The study group received 10micrograms of T3 in place of 50micrograms of T4 while the ...