Searchable abstracts of presentations at key conferences in endocrinology

ea0035p832 | Pituitary Basic (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2014

Correlation of coexpression of pituitary genes in QPCR and microarray study in pituitary adenomas

Zebracka-Gala Jadwiga , Larysz Dawid , Pfeifer Aleksandra , Rudnik Adam , Krajewska Jolanta , Hasse-Lazar Kornelia , Kowalska Malgorzata , Bazowski Piotr , Jarzab Barbara

Introduction: Mechanism of pathogenesis of pituitary adenomas is still unknown. Gene expression differences in pituitary cells of different origin are not extensively described. Identification of genes specific for pituitary adenomas should enable better understanding of differences in their response to therapy, especially to radiotherapy.Aim: The aim of our study was to evaluate the correlation of coexpression of distinct pituitary adenoma genes based o...

ea0092ps1-09-09 | Thyroid Cancer | ETA2023

A novel somatic genetic alteration in sporadic medullary thyroid carcinoma

Kowalska Malgorzata , Pfeifer Aleksandra , Zebracka-Gala Jadwiga , Cieślicka Marta , Chmielik Ewa , Rusinek Dagmara , Krajewska Jolanta , Czarniecka Agnieszka , Oczko-Wojciechowska Malgorzata

Introduction: Medullary thyroid carcinoma (MTC) is a malignant thyroid tumor originating from parafollicular C-cells. Most of MTCs (75%) are sporadic while remaining are hereditary. The hereditary form of MTC is a consequence of the mutation of the proto-oncogene RET (Rearranged During Transfection). Somatic mutations of the RET gene are also present in 40%-70% of the sporadic form of MTC (sMTC). Somatic mutations are also observed in the RAS genes and very rarely in the BRAF ...

ea0035oc5.5 | Adrenal &amp; Thyroid | ECE2014

Validation of follicular thyroid cancer molecular classifier in fine-needle aspiration biopsy samples

Pfeifer Aleksandra , Bartosz Wojtas , Malgorzata Oczko-Wojciechowska , Aleksandra Kukulska , Agnieszka Czarniecka , Markus Eszlinger , Thomas Musholt , Tomasz Stokowy , Ewa Stobiecka , Jolanta Krajewska , Dagmara Rusinek , Tomasz Tyszkiewicz , Monika Kowal , Michal Jarzab , Steffen Hauptmann , Dariusz Lange , Ralf Paschke , Barbara Jarzab

Introduction: Follicular adenomas (FTA) and carcinomas (FTC) are thyroid tumours that are indistinguishable in the fine needle aspiration biopsy (FNAB). In our previous research we concentrated on post-operative material and developed the classifier, which discriminates the FTC and FTA, based on formalin-fixed paraffin-embedded (FFPE) material. The classifier was based on expression of five genes and gave the promising sensitivity of 71% and specificity of 72%. The aim of the ...