Searchable abstracts of presentations at key conferences in endocrinology

ea0014p632 | (1) | ECE2007

Adrenal rest tissue in gonads in 70 French patients with classical congenital adrenal hyperplasia (21 hydroxylase deficiency)

Peggy Pierre , Francois Despert , Francois Tranquart , Christine Chabrolle , Veronique Kerlan , Emmanuel Sonnet , Chantal Metz , Sabine Baron , Marc De Kerdanet , Regis Coutant , Philippe Emy , Francoise Monceau , Said Bekka , Pierre Lecomte

Congenital adrenal hyperplasia (CAH) due to 21 hydroxylase deficiency is one of the most frequent endocrine genetic diseases. Adrenal rests have been described and can decrease fertility in men1. In a retrospective multi-center study we wanted evaluate the frequency of adrenal rests in classical forms of CAH (21-OH deficiency) by systematic ultrasonography (US); try to find the cause of this abnormality looking for a relationship between genotype and pheno...

ea0081oc2.3 | Oral Communications 2: Adrenal and Cardiovascular Endocrinology 1 | ECE2022

Loss of lysine demethylase KDM1A in GIP-dependent bilateral macronodular adrenal hyperplasia with Cushing’s syndrome

Chasseloup Fanny , Bourdeau Isabelle , Tabarin Antoine , Regazzo Daniela , Dumontet Charles , Ladurelle Nataly , Tosca Lucie , Amazit Larbi , Proust Alexis , Scharfmann Raphael , Fiore Frederic , Tsagarakis Stylianos , Vassiliadi Dimitra , Maiter Dominique , Young Jacques , Lecoq Anne-Lise , Demeocq Vianney , Salenave Sylvie , Lefebvre Herve , Cloix Lucie , Emy Philippe , Desailloud Rachel , Vezzosi Delphine , Scaroni Carla , Barbot Mattia , de Herder Wouter , Pattou Francois , Tetreault Martine , Corbeil Gilles , Dupeux Margot , Lambert Benoit , Tachdjian Gerard , Guiochon-Mantel Anne , Beau Isabelle , Chanson Philippe , Viengchareun Say , Lacroix Andre , Bouligand Jerome , Kamenicky Peter

Context: Primary bilateral macronodular adrenal hyperplasia (PBMAH) with glucose-dependent insulinotropic polypeptide (GIP)-dependent CushingÂ’s syndrome is caused by ectopic expression of GIP receptor in the adrenal tissue. The bilateral nature of this adrenal disease suggests germline genetic predisposition. We aimed to identify the molecular driver event responsible for ectopic GIP receptor expression in PBMAH.Methods: We conducted an internationa...

ea0057021 | Cardiovascular complications in pituitary gigantism (results of an international study) | BES2018

Cardiovascular complications in pituitary gigantism (results of an international study)

Liliya Rostomyan , Adrian Daly , Nalini Shah , Luciana A Naves , Anne Barlier , Marie-Lise Jaffrain-Rea , Philippe Emy , Sebastian Neggers , Lecumberri Santamaria Beatriz , Ian Holdaway , Thierry Brue , Gunter Stalla , Roberto Salvatori , Yves Bertherat Jerome , Dominique Maiter , Margaret Zacharin , Anurag Lila , Silvia Filipponi , Satinath Mukhopadhyay , Tapani Ebeling , Marja Ojaniemi , I McCormack Ann , Outi Kuismin , Anne-Lise Lecoq , Mona Sahnoun-Fathallah , Caroline Jung-Sievers , Elena Malchiodi , Liudmila Rozhinskaya , Elena Nazzari , Sachin Mittal , Elisa Verrua , Ekaterina Sorkina , Alexander Dreval , France Devuyst , Ismene Bilbao , Simona Auriemma Renata , Palacios Garcia Nuria , Irena Ilovaiskaya , Vyacheslav Pronin , Annamaria Colao , Diego Ferone , Anna Spada , Patrick Petrossians , Paolo Beck-Peccoz , A Stratakis Constantine , Philippe Chanson , Albert Beckers

Background: Cardiovascular disease is an important cause of morbidity/mortality in chronic GH hypersecretion.Aim: To evaluate cardiovascular system in a large series of patients with pituitary gigantism. Standard case report forms were used with height assessments related to local country norms. Results: 151pts (123 male) with GH-excess and abnormal growth velocity for age or final height >2SD over local norms had complete data on cardiac assessments...