Endocrine Abstracts

It is known that in type 1 diabetes mellitus (T1DM) continuous subcutaneous insulin infusion (CSII) therapy improves metabolic control and reduces risk of hypoglycaemia in comparison with multiple daily injection (MDI). Metabolic outcomes usually considered are HbA1c, BMI, and inflammatory parameters. However few data are available on pituitary and gonadal hormone responses, which are involved in metabolic processes. In order to study the response of anabolic hormones in patie...

Reg and Reg-related genes are members of a multifunctional family. Under physiological conditions Reg protein is not expressed in pancreatic beta cells, although the Reg protein receptor is expressed. When islets are damaged, the expression of Reg gene is increased in the islets of Langherans. In type 1 diabetes (T1D), insulin secretion may be still detectable in some subjects with long-standing disease indicating the existence of a small population of surviving beta cells or ...

Background: red blood cells (RBC) membrane fluidity in patients with type 2 diabetes mellitus (T2DM) can be influenced by various factors like oxidative stress, aging, glycosylation, lipid homeostasis and exposure to nutrients.Objective: To analyze RBC membrane fluidity in patients with long-duration T2DM (more than 10 years), looking for any differences between patients without and with macroangiopathy (vascular diabetic foot).Met...

Background: Cell membrane fluidity of erythrocytes in patients with type 2 diabetes can be influenced by glycosylation processes, changes in lipid homeostasis and oxidative stress.Objectives: We have measured red blood cell membrane fluidity looking for differences between healthy people and diabetic subjects and also between diabetic patients affected by macroangiopathy (vascular diabetic foot) and not.Methods: We have enrolled 32...