Searchable abstracts of presentations at key conferences in endocrinology

ea0028s10.4 | Current concepts and management of phaeochromocytoma | SFEBES2012

Novel therapies for malignant phaeochromocytoma and paraganglioma

Pierre Plouin

There is currently no curative treatment for metastatic phaeochromocytoma (PH) and paraganglioma (PG). Patient management aims at reducing tumor burden and preventing mechanical and secretory consequences of metastatic spread and must be adapted to disease progression. Focal treatments (surgery, radiofrequency ablation and embolization) reduce hypersecretion and facilitate subsequent systemic therapies using radionuclides (131I-MIBG, 177Lu- or 90Y-DOTATOC), chemotherapy (cyclo...

ea0026mte17 | (1) | ECE2011

Management of phaeochromocytomas and paragangiolomas

Plouin Pierre-Francois

Pheochromocytomas (PH) and functional paragangliomas (PGL) are neoplasms of chromaffin tissue that synthesize catecholamines. The diagnosis of PH or functional PGL is based on the determination of metanephrines. Most catecholamine-secreting tumors arise in the adrenal glands (PH proper) and are easily detected by computed tomography or magnetic resonance imaging. Patients may also harbor extraadrenal primary tumors (PGL) or distant metastases. Adrenal imaging should therefore ...

ea0035p49 | Adrenal cortex | ECE2014

The influence of diagnostic criteria on the interpretation of adrenal venous sampling

Lethielleux Gaelle , Amar Laurence , Plouin Pierre-Francois , Steichen Olivier

Objective: Recent guidelines promote adrenal venous sampling (AVS) as the reference test to document lateralised aldosterone hypersecretion in primary aldosteronism (PA). However, there are wide discrepancies between institutions in the criteria used. Our objective was to evaluate their consequences on the interpretation of AVS results.Design and methods: All 506 AVS performed from 01/2001 to 03/2009 in our institution were included. Results were interpr...

ea0026p16 | Adrenal cortex | ECE2011

Potential role of mast cells in the physiopathology of aldosterone-producing adenoma

Duparc Celine , Moreau Lucile , Perraudin Veronique , Gobet Francoise , Meatchi Tchao , Plouin Pierre-Francois , Zennaro Maria-Christina , Louiset Estelle , Lefebvre Herve

We have shown that 5-hydroxytryptamine (5-HT) receptor type 4 (5-HT4R) agonists stimulate aldosterone production in patients with aldosterone-producing adenoma (APA). Moreover, 5-HT-positive cells were observed in APA tissues and 5-HT4R mRNAs were markedly overexpressed in APAs in comparison with normal adrenals. All these results suggested that 5-HT produced by adrenal mast cells could be involved in the physiopathology of APAs. The aim of this work was to investigate the rol...

ea0014s8.1 | Advances in adrenal hypersecretory disorders | ECE2007

Autocrine-paracrine pathways in primary adrenal disorders

Lefebvre Hervé , Contesse Vincent , Cartier Dorthe , Perraudin Véronique , Delarue Catherine , Vaudry Hubert , Bertherat Jérôme , Plouin Pierre-François , Kuhn Jean-Marc , Louiset Estelle

It is now well demonstrated that, in the human adrenal gland, aldosterone and cortisol productions are stimulated by autocrine/paracrine factors, like serotonin (5-HT) and arginine vasopressin (AVP). Several data indicate that these signals may also be involved in the regulation of corticosteroidogenesis in adrenocortical hyperplasias and tumors. 5-HT is detected in clusters of steroidogenic cells in aldosterone-producing adrenocortical adenomas (APAs), and in both ACTH-indepe...