Endocrine Abstracts

Background and Aim: Polycystic ovary syndrome (PCOS) is associated with compositional and functional alterations in gut microbiota. The cytokine interleukin-22 (IL-22) is produced by both innate and adaptive immune cells and closely linked to gut immunity. IL-22 is tightly controlled by its binding protein (IL-22BP), which serves as an antagonist of IL-22 signaling. Preliminary animal studies and limited human data in Asian populations suggest lower circulating levels of IL-22...