Endocrine Abstracts

Dehydroepiandrosterone is the most abundant steroid hormone circulating in the human body, we focused on its 7-hydroxylated derivatives. Many observations in rodents have demonstrated the anti-inflammatory and immune modulating activity of 7β-hydroxy-androst-5-enes, and on the basis of these experiments androst-5-ene-3β,7β,17β-triol is considered as a potential agent in the treatment of autoimmune diseases. In contrast to the fairly abundant information on ...

Abstract: Dihydrotestosterone (DHT) is the most powerful naturally occurring androgen with three to six times higher biopotency than testosterone. Time onset of benign prostatic hyperplasia and alopecia in middle life could be the result of an imbalance between androgens. The decline of testosterone during lifespan is well known, controversial data can be found concerning the age dependence of DHT levels. We analysed the levels of testosterone, dihydrotestosterone and SHBG fro...

Diagnostic tests of the hypothalamic–pituitary–adrenal axis (HPA axis), measuring of free cortisol and use of other adrenal steroids are the subject of debate.We investigated 15 healthy men with mean/median age 27.4/26 (±4.8) years, and mean/median BMI 25.38/24.82 (±3.2) kg/m2. All subjects underwent four dynamic tests of the HPA axis, specifically 1, 10, and 250 μg synacthen tests and an insulin tolerance test (ITT). ...