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19th European Congress of Endocrinology

Lisbon, Portugal
20 May 2017 - 23 May 2017

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20-23 May 2017, Lisbon, Portugal Further information

ea0049ep1157 | Male Reproduction | ECE2017

Analysing by decade, testosterone undecanoat depot injectable does not increases prostate volume. Study during up to 9 years on hypogonadic patients. (December 2016)

Pisoschi Matei , Cristina Staicu Dana , Peretianu Dan

Aim: Re-analyzing (study starting in 2007) the effect of injectable testosterone undecanoat depot (TUD) in hypogonadic patients.Materials and Methods: A. Patients: at onset 231 men with hypogonadism (median: 62 y). B. Distribution: by decade (starting with 20y); no =4, 14, 24, 61, 63, 49, 17, 1. C. TUD (NebidoR-Bayer) 1000 mg injected one/3 months i.m. D. Prostate volume (PV) appreciated by per-abdominal ultrasound: 3.5–5 MHz probe, ellip...

ea0049ep1158 | Male Reproduction | ECE2017

After 9 years observation, testosterone undecanoat 1000 mg at 3 months did not increased Prostatic Specific Antigen level (December 2016)

Pisoschi Matei

Aim: Has testosterone undecanoat 1000 mg injection (NebidoR; Bayer), 1/3month negative effect on prostate?Material and method: i) PSA (ng/ml) was registred retrospective (from files) and prospective analysis (onset 2010). ii) Patients: PSA analysis was done before treatment and recorded at T1 to T12 [2 weeks to 9 years] (see Pisoschi, this Congress). iii) Statistical analysis: Student test, simple correlation, multiple regression.<p class=...

ea0049ep1159 | Male Reproduction | ECE2017

Induction of male puberty in patients with hypogonadism hypogonadotrope with subcutaneous gonadotropin

Moreno-Moreno Paloma , Munoz-Jimenez Concepcion , Alhambra-Exposito Maria Rosa , Galvez-Moreno Maria Angeles

Objective: The most used therapeutic guidelines for the induction of male puberty in hypogonadotropic hypogonadism (HH) are GnRH in subcutaneous pulsatile infusion and HCG in monotherapy or combined with FSH in intramuscular injection. The objective of this study was to evaluate the efficacy of subcutaneous HCG with or without FSH in induction of male puberty in patients with HH.Patients and methods: Descriptive study of patients with HH treated with HCG...

ea0049ep1160 | Male Reproduction | ECE2017

Semen quality in young, healthy men is not related to serum concentration of vitamin D (AndroLS)

Jozkow Pawel , Zagrodna Aleksandra , Medras Marek , Lwow Felicja , Slowinska-Lisowska Malgorzata

Introduction: Relationships between vitamin D and male fertility are not fully elucidated. Studies in infertile/subfertile subjects suggest that vitamin D status may be associated with semen parameters (1, 2). Data from healthy men is inconclusive (3, 4). Our purpose was to evaluate the andrological status and a range of biochemical, dietary and lifestyle variables in healthy men aged 18–35, living in the region of Lower Silesia (Poland) (AndroLS).M...

ea0049ep1161 | Male Reproduction | ECE2017

Semen quality in patients with newly diagnosed lymphoma’s

Peros Kristijan , Milotic Dubravka Majic , Bozek Tomislav , Stakor Mia Sunjic , Babic Kristina Kljajic , Dobrota Vesna Dermanovic , Magas Sasa

Objective: To analyse the semen quality in patients with newly diagnosed lymphoma’s before starting the treatment.Materials and methods: We evaluated semen quality in 131 patient with lymphoma who underwent sperm banking in our clinic over a 14-year period. 102 patients had Hodgkin’s lymphoma, and 29 had non-Hodgkin’s lymphoma. Semen samples were collected by masturbation after 2–7 days of sexual abstinence. Age at banking, semen volu...

ea0049ep1162 | Male Reproduction | ECE2017

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ea0049ep1163 | Male Reproduction | ECE2017

Gonadal profile in men with early-onset androgenetic alopecia: does a male PCOS-equivalent syndrome exist?

Cannarella Rossella , Condorelli Rosita A , Vignera Sandro La , Mongioi Laura M , Vicari Enzo S , Micali Giuseppe , Calogero Aldo E

Importance: Early-onset androgenetic alopecia (AGA) has been suggested as a phenotypic sign of the male polycystic ovary syndrome (PCOS)-equivalent since men with this feature have a PCOS-like hormonal pattern. No study has evaluated the gonadal function of these men.Objective: To study the gonadal function of men with early-onset AGA and to identify suggestive criteria of male PCOS-equivalent.Design: This case-control study was co...

ea0049ep1164 | Male Reproduction | ECE2017

Improved conception of the normative values of testosterone in men with type 2 diabetes

Khripun Irina , Vorobyev Sergey , Dzantieva Elizaveta , Belousov Igor , Kogan Michail , Zitzmann Michael

Background: Men with type 2 diabetes mellitus (T2DM) have significantly lower levels of testosterone (T) than nondiabetic controls. But androgen deficit symptoms may be detected in males with normal T levels.Aim: To analyze parameters of lipid, carbohydrate metabolism and endothelial function in diabetic males with low normal and middle-to-high normative T levels.Patients and methods: We examined 86 men with T2DM and serum T levels...

ea0049ep1165 | Male Reproduction | ECE2017

Endothelial dysfunction, inflammation and insulin resistance in patients with Klinefelter Syndrome

Haymana Cem , Aydogdu Aydogan , Demirci Ibrahim , Dinc Mustafa , Demir Orhan , Torun Deniz , Yesildal Fatih , Meric Coskun , Basaran Yalcin , Sonmez Alper , Azal Omer

Introduction: The prevalence of cardiometabolic disorders such as type 2 diabetes mellitus, dysipidemia and metabolic syndrome is increased in patients with Klinefelter syndrome (KS). The mechanism by which cardiometabolic risk increases in patients with KS remains to be completely elucidated. We investigated the presence of inflammation, insulin resistance and endothelial dysfunction in an unconfounded population of KS.Methods: A total of 31 patients wi...

ea0049ep1166 | Male Reproduction | ECE2017

Testosterone is poorly related to erectile dysfunction in young/middle aged human immunodeficiency virus-infected men

Vincentis Sara De , Santi Daniele , Decaroli Maria Chiara , Fanelli Flaminia , Mezzullo Marco , Fazzini Alessia , Ansaloni Anna , Pagotto Uberto , Guaraldi Giovanni , Rochira Vincenzo

Background: human immunodeficiency virus (HIV)-infection is strongly associated to erectile dysfunction (ED) in men. Preliminary data suggests that ED is poorly associated with serum T in HIV+ men.Aim: To investigate in HIV-infected men the relationship between sexual function as assessed by the validated International Index of Erectile Function (IIEF-15) and T deficiency using Liquid Chromatography-tandem Mass Spectrometry (LC-MS/MS).<p class="abste...

ea0049ep1167 | Male Reproduction | ECE2017

Early arterial stiffness and chronic inflammation in male equivalents of polycystic ovary syndrome

Sozen Mehmet , Baldane Suleyman , Abusoglu Sedat , Kebapcilar Levent , Kebapcilar Aysegul , Akyurek Fatma , Unlu Ali , Ipekci Suleyman Hilmi

Introduction: There is some evidence that a rise in the androgen hormone levels increases the risk for the development of a cardiovascular disease, obtained from the studies conducted on women with polycystic ovary and on men with androgenic alopecia. Inflammatory substances tend to increase in polycystic ovary syndrome and in androgenic alopecia. On this basis, we conducted a study that aimed to evaluate the early cardiovascular and metabolic effects in male patients with and...

ea0049ep1168 | Male Reproduction | ECE2017

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ea0049ep1169 | Male Reproduction | ECE2017

Can salivary testosterone be used in the monitoring of men using transdermal testosterone replacement therapy?

Ahern Tomas , Adaway Jo , Monaghan Phillip , Trainer Peter , Keevil Brian

: In community-dwelling men, salivary testosterone (Sal-T) concentrations are thought to represent tissue hormone levels and correlate strongly with serum free-T levels. Measurement of salivary glucocorticoid concentrations is a non-invasive and objective means of assessing cortisol exposure in users and non-users of hydrocortisone therapy. We assessed relationships of Sal-T with transdermal testosterone replacement therapy (TD-TRT) and with markers of testosterone exposure. I...

ea0049ep1170 | Male Reproduction | ECE2017

Changes of dihydrotestosterone within the life in men

Pospišilova Hana , Duškova Michaela , Hill Martin , Starka Luboslav

Abstract: Dihydrotestosterone (DHT) is the most powerful naturally occurring androgen with three to six times higher biopotency than testosterone. Time onset of benign prostatic hyperplasia and alopecia in middle life could be the result of an imbalance between androgens. The decline of testosterone during lifespan is well known, controversial data can be found concerning the age dependence of DHT levels. We analysed the levels of testosterone, dihydrotestosterone and SHBG fro...

ea0049ep1171 | Male Reproduction | ECE2017

Male pseudohermaphroditism with 45,X/46,X,idic(Y) karyotype: a case presenting with dysgenetic testis on one side and almost normally sized testis on the other side

Di Bari Flavia , Vita Roberto , Benvenga Salvatore

: Dicentric Y chromosome [idic(Y)] is the most common structural abnormality of this chromosome, and generally results from altered meiotic breakage and reunion of sister chromatids. Since this rearrangement is unstable, idic(Y) may be lost in subsequent cell cycles, resulting in a mosaic 45,X cell line. Variable are the phenotype and gonads (from streak gonads to ovotestes or dysgenetic testes). Few cases of 45,X/46,X,idic(Y) male pseudohermaphroditism with testes have been r...

ea0049ep1172 | Male Reproduction | ECE2017

Effects of anabolic androgenic steroids on the reproductive system of athletes

Christou Maria , Christou Panagiota , Markozannes Georgios , Tsatsoulis Agathocles , Mastorakos George , Tigas Stelios

Background: Anabolic androgenic steroids (AAS) are widely used to improve performance and/or enhance appearance. The aim of this study was to assess the impact of AAS on the reproductive system of athletes.Methods: An electronic literature search was conducted, using the databases MEDLINE, CENTRAL, Scopus and Google Scholar. Studies including AAS use in any type, dose, form or duration of intake were included in the review. Main outcomes were AAS effects...

ea0049ep1173 | Male Reproduction | ECE2017

Gonadal status in males with acute coronary syndrome and the extent of coronary artery disease: a comparative cross-sectional analysis

Bednarova Adriana , Koller Tomaš , Kužma Martin , Payer Juraj

Introduction and aims: Association between coronary artery disease (CAD) and male gonadal status has been previously suggested, but still remains inconclusive. Aims of our study in males with recent acute coronary syndrome (ACS) were to evaluate the prevalence of hypogonadism, to compare their gonadal status with non-ACS matched controls and to evaluate gonadal status by the extent of CAD.Subjects and Methods: A cross-sectional retrospective study includ...

ea0049ep1174 | Male Reproduction | ECE2017

An unusual karyotype in a young adult with a clinical phenotype suggesting a Klinefelter syndrome

Garcia-Garcia-Doncel Lourdes , Torres-Barea Isabel , Cayon-Blanco Manuel , Marquez-Pardo Rosa , Lopez-Velasco Rosario , Baena-Nieto Gloria

Introduction: 46 XX testicular DSD (disorder of sex development) is a rare syndrome characterized by 46 XX karyotipe, male external genitalia, azoospermia, sterility and usually hypergonadotropic hypogonadism in adulthood. Approximately 85% of individuals present after puberty with normal penile size, small testes and gynecomastia.Case report: We present a 34-year-old male who was referred for endocrine evaluation due to slightly high prolactin levels. H...

ea0049ep1175 | Male Reproduction | ECE2017

A case with taurodontism and Klinefelter syndrome

Taskaldiran Isilay , Omma Tulay , Karaca Anara , Taskaldiran Alper , Ersoz Gulcelik Nese

: In this paper we present an 18-year-old patient with Klinefelter syndrome who has taurodontism. Klinefelter syndrome is the most common abnormality of sex chromosomes. It is characterized by hypogonadism, gynaecomastia, azoospermia or oligospermia, and increased levels of gonadotropins. Associated medical disorders can be categorized as follows; cancer, autoimmune disorders, intellectuel and psychiatric disorder, osteoporosis, endocrine disorders, venous disease and taurodon...

ea0049ep1176 | Male Reproduction | ECE2017

Methylation of the CPG islands from MTHFR promoter in male infertility

Vladoiu Suzana , Botezatu Anca , Dinu Draganescu Daniela , Manda Dana , Oros Sabina , Paun Diana , Rosca Roxana , Badiu Corin , Anton Gabriela

: A large number of studies are now focused on the causes of male infertility. Among these are epigenetic modifications, which are important contributors to reproductive pathology in the male by providing dynamic changes of the phenotype according to the environmental and metabolic factors. The most known epigenetic modification is DNA methylation and alterations in this pattern in several genes could induce male infertility. Alterations in DNA methylation patterns in several ...

ea0049ep1177 | Male Reproduction | ECE2017

How relevant are the complications associated with testosterone treatment in men with hypogonadism?

Capitao Ricardo , Castro Raquel , Ferrinho Catia , Santos Francisco , Roque Catarina , Bello Carlos , Sequeira Joao , Saraiva Catarina , Vasconcelos Carlos

Introduction: Testosterone treatment in patients with hypogonadism has been associated with cardiovascular and prostatic complications.Objective: To describe the evolution of analytical parameters associated to the complications of testosterone treatment in a male population with hypogonadism treated with testosterone. Methods A retrospective, longitudinal study in which the clinical data of male adults with hypogonadism under intramuscular testosterone ...

ea0049ep1178 | Male Reproduction | ECE2017

Evolution of healthcare demand in a public gender identiy clinical center in Valencia (spain)

Moya Victor Atienza , Gomez Balaguer Marcelino , Murillo Felipe Hurtado , Torres Santiago Garcia , Sabater Eva Maria Riera , Vendrell Christian Salim , Mijares Antonio Hernandez

Introduction: The prevalence of transsexuality in Europe is uncertain in absence of epidemiological studies, so it’s difficult to implement public healthcare strategies.Aim: To describe healthcare demand evolution in a gender identity clinical service in our country.Methods: Our center is a public university hospital placed in Valencia (Spain). It is a reference center on gender dysphoria from two provinces (Valencia and Caste...

ea0049ep1179 | Male Reproduction | ECE2017

Leptin modulates Sertoli cells mitochondrial function and biogenesis with implications for the nutritional support of spermatogenesis

Moreira Bruno M , D Martins Ana , Monteiro Mariana P , Sousa Mario , Alves Marco G , Oliveira Pedro F

Current lifestyle, characterized by physical inactivity and a poor diet, is heavily linked with an increased incidence of metabolic diseases. One of the most serious silent co-morbidities of those diseases is infertility. The hormonal link between food intake and energy homeostasis is mediated by the leptin ghrelin axis. Compelling evidence suggests that direct leptin’s action regulates cellular glucose homeostasis and mitochondrial biogenesis. We have recently shown that...

ea0049ep1180 | Male Reproduction | ECE2017

Study of CDX-2 VDR gene polymorphisms in male infertility

Vladoiu Suzana , Draganescu Daniela Dinu , Botezatu Anca , Manda Dana , Oros Sabina , Rosca Roxana , Anton Gabriela , Paun Diana , Badiu Corin

The CDX2 VDR polymorphism (rs11568820) is located in the promoter region of exon 1 in the 5′-untranslated region of the VDR gene.Objective: The current investigation examines the association between CDX2 VDR polymorphism and male infertility.Subjects and methods: The study was conducted on 69 infertile men, aged between 20 and 50 years, divided into three groups, based on spermatic parameters: group with azoospermia (19 subje...

ea0049ep1181 | Male Reproduction | ECE2017

CHARGE syndrome – late diagnosis in adulthood

Costa Maria Manuel , Esteves Cesar , Castedo JoseLuis , Pignatelli Duarte , Carvalho Davide

Introduction: CHARGE syndrome is a rare autossomal dominant genetic disorder with an estimated birth incidence of 1:10000. It affects multiple organ systems and can have a variable phenotypic expression.Case report: 34-years-old man, referred to Endocrinology in the context of bilateral gynecomastia. He had an acute corneal hydrops which was treated by ophthalmology. Physical examination showed short stature (149 cm), obesity (BMI 31.5 kg/m2),...

ea0049ep1182 | Male Reproduction | ECE2017

Azoospermia revealing the uncommon Jacob’s syndrome

Yahi Abdelkader , Haouchine Zakaria , Ould-Kablia Samia

Introduction: Dysgonosomies are abnormalities of the number of gonosomes X and Y. They have fewer Phenotypic repercussions than the aneuploidies involving autosomes, and are mostly viable. The 47 XYY are generally boys with normal phenotype. The prevalence is around 1 per 1000 birth boy but undoubtedly under diagnosed given the often normal phenotype associated with this chromosomal formula, in addition to the lack of large-scale studies. There is no gonadal dysgenesis and oft...