Searchable abstracts of presentations at key conferences in endocrinology

ea0026p586 | Clinical case reports | ECE2011

A case report of macronodular adrenal hyperplasia with combined cortisol and aldosterone oversecretion in response to β-adrenergic and vasopressin stimuli

Papanastasiou L , Pappa T , Tsiavos V , Tseniklidi E , Prevoli A , Tsounas P , Markou A , Piaditis G

Introduction: Adrenocorticotropin (ACTH)-independent macronodular adrenal hyperplasia (AIMAH) is a rare cause of CushingÂ’s syndrome, commonly involving the aberrant expression of several membrane-bound adrenal receptors. Recent studies have investigated whether the latter is also implicated in the renin-independent aldosterone secretion of hyperaldosteronism cases.Case report: A 35-year-old man presented to our department for evaluation of new-onset...

ea0020p30 | Adrenal | ECE2009

Study of hormonal activity and insulin resistance in patients harbouring incidentally discovered bilateral adrenal adenomas

Androulakis Ioannis , Papanastasiou Lambrini , Tsenilklidi Ermioni , Prevoli Anastasia , Kafritsa Paraskevi , Pappa Theodora , Tsiavos Vaios , Piaditis George

Background: Hormonal activity and insulin resistance (IR) in patients with incidentally discovered bilateral adrenal adenomas (BA) has not been evaluated until now. Therefore, we have investigated cortisol and aldosterone secretion and IR in 29 patients with BA, in 113 patients with unilateral adrenal adenomas (UA) and in 89 healthy subjects (C).Methods: All subjects underwent the following investigation: 1) Low dose dexamethasone suppression test (LDDST...

ea0029p58 | Adrenal cortex | ICEECE2012

Treatment with mineralocorticoid receptor antagonists in ‘subclinical’ cases with adrenal adenomas and autonomous aldosterone secretion

Papanastasiou L. , Pappa T. , Tsounas P. , Tsiavos V. , Markou A. , Tseniklidi E. , Anastasakou M. , Fountoulakis S. , Prevoli A. , Piaditis G.

Introduction: Patients with adrenal adenomas appear to exhibit an appreciable prevalence of autonomous aldosterone secretion (AAS). Our aim was to evaluate the anti-hypertensive effect of targeted therapy with mineralocorticoid receptor (MR) antagonists in AAS patients.Patients and methods: We studied 60 hypertensive patients, 21 males and 39 females, harboring an adrenal adenoma with AAS. All patients were receiving combination of anti-hypertensive trea...

ea0022p378 | Endocrine tumours &amp; neoplasia (<emphasis role="italic">Generously supported by Novartis</emphasis>) | ECE2010

Identification of a novel mutation of MEN1 gene in a patient with persisting primary hyperparathyroidism

Papanastasiou Labrini , Prevoli Anastasia , Pappa Theodora , Kamakari Smaragda , Kafritsa Paraskevi , Metaxa-Mariatou Vassiliki , Markou Athina , Piaditis George

Background: Multiple endocrine neoplasia type 1 (MEN1) syndrome is an autosomal dominant disorder characterized by the presence of endocrine and nonendocrine tumors. Until recently, more than 450 different germline mutations have been reported in MEN1 patients involving frameshift deletions, insertions, as well as nonsense mutations.Aim: To report a novel mutation in MEN1 gene in a young female with persisting primary hyperparathyroidism.<p class="ab...