Searchable abstracts of presentations at key conferences in endocrinology

ea0081p478 | Thyroid | ECE2022

Thyroid nodules and glucose metabolism derangements: does sex matter?

Gagliardi Irene , Gobbo Alberto , ROSSI ROBERTA , Rossi Martina , Rosaria Ambrosio Maria , Chiara Zatelli Maria

Background: Glucose metabolism derangements (GMD) and thyroid nodules (TN) are the most frequent endocrine disorders. A relationship between these conditions has been suggested, but data are still controversial and no evidence was reported regarding sex differences.Aim: To evaluate the distribution of impaired fasting glucose (IFG), normal glucose tolerance (NGT), impaired glucose tolerance (IGT), type 2 diabetes (T2DM) and TN according to sex.<p cla...

ea0073pep5.2 | Presented ePosters 5: Thyroid | ECE2021

Low-risk papillary thyroid carcinoma: outcome predictive factors in a cohort of patients not treated with radioiodine therapy after total thyroidectomy

Gagliardi Irene , Mella Alessandro , Rossi Roberta , Pontrelli Margherita , Rossi Martina , Chiara Zatelli Maria

BackgroundPapillary thyroid carcinoma (PTC) is the most frequent thyroid malignant neoplasm. American Thyroid Association (ATA) guidelines don’t specify how to follow-up low-risk PTC patients not receiving radioiodine therapy (RAI) after total thyroidectomy (TT). Indeed, there is no consensus among authors regarding the interpretation of thyroglobulin (TG) levels and ultrasound neck (US) findings during follow-up in these settings.<p class="abst...

ea0022oc2.3 | Thyroid | ECE2010

Allelic discrimination in the diagnosis of somatic BRAF V600E mutation on fine-needle aspiration biopsies

Buratto Mattia , Tagliati Federico , Trasforini Giorgio , Leoni Stefania , Rossi Roberta , degli Uberti Ettore C , Zatelli Maria Chiara

Many studies demonstrated that somatic BRAF gene mutation analysis increases diagnostic accuracy for papillary thyroid carcinoma (PTC), even from very small samples. The gold standard for point mutations research is direct sequencing, that implies DNA extraction, PCR with specific primers, sequencing reaction and run on an automatic sequencer. This is an expensive and time consuming method, and the possible contamination with wild-type DNA not coming from the nodule significan...

ea0022p789 | Thyroid | ECE2010

BRAFV600E analysis on fine needle aspiration biopsy increases diagnostic accuracy for papillary thyroid cancer in clinically unsuspected nodules

Rossi Martina , Trasforini Giorgio , Leoni Stefania , Tagliati Federico , Rossi Roberta , Roti Elio , degli Uberti Ettore C , Zatelli Maria Chiara

Papillary thyroid cancer (PTC) represents the majority of differentiated thyroid cancers, presenting in 29–83% of cases the activating BRAF V600E mutation. The aim of our study was to analyse the influence of BRAF V600E mutation analysis on diagnostic accuracy of fine needle aspiration biopsies (FNAB) in clinically unsuspected thyroid nodules. We therefore enrolled 496 patients (383 females, 113 males; mean age 52 years), for a total of 671 samples. FNAB were evaluated by...

ea0063gp87 | Thyroid Nodules and Cancer | ECE2019

Intronic RAS and PI3KCA mutations identified by Next Generation Sequencing in thyroid nodules with indeterminate cytology may associate with follicular thyroid cancer

Borges de Souza Patricia , Rossi Lucrezia , Crociara Anna , Rossi Roberta , Ambrosio Maria Rosaria , Rossi Martina , Bondanelli Marta , Lanza Giovanni , Zatelli Maria Chiara

Introduction: Accurately discern malignant from benign nodules sometimes represents a real challenge. Fine needle aspiration (FNA) biopsy, ultrasound and The Bethesda System for Reporting Thyroid Cytopathology (BSRTC) allow for accurate diagnosis in 60–80% of all nodules. However, 10–20% of thyroid FNAs yield an indeterminate cytology (BSRTC III and IV categories). The real malignancy rate of BSRTC III category is difficult to ascertain because histopathological anal...

ea0037ep868 | Thyroid cancer | ECE2015

Role of miR-26a in follicular thyroid carcinoma

Gentilin Erica , Ortolan Elisa , Gagliano Teresa , Pasquale Carmelina Di , Falletta Simona , Rossi Roberta , Benfini Katiuscia , Tagliati Federico , Uberti Ettore Degli , Zatelli Maria Chiara

Follicular thyroid carcinoma (FTC) is the second most common thyroid malignant epithelial tumor. It is clinically asymptomatic, usually represented by a single nodule, less often multiple, with origin from thyroid follicular epithelial cells. Despite its well-differentiated characteristics, FTC may develop distant metastases through hematogenous dissemination. The molecular alterations involved in the pathogenesis of follicular neoplasia are not completely known. Recent studie...