Searchable abstracts of presentations at key conferences in endocrinology

ea0011s88 | Contrasting practices in European endocrinology | ECE2006

Diagnosis of hypercortisolism

Feelders RA

The diagnosis and differential diagnosis of hypercortisolism can be a major clinical challenge and involves several stages. In each stage different approaches are currently followed. There are, however, some general principles. In brief, after critical judgement of clinical features, the first step is to assess whether endogenous hypercortisolism is present. First-line tests to screen for hypercortisolism include measurement of 24 h urinary cortisol excretion, cortisol diurnal...

ea0092ps3-27-07 | Thyroid Cancer clinical 3 | ETA2023

Clinical significance of de novo appearance of anti-thyroglobulin antibodies in patients of differentiated thyroid cancer with radioiodine therapy

Shim Hyekyung , Ra Kim Mi

Objectives: This study analyzed the prevalence of newly discovered anti-thyroglobulin antibody (TgAb) and its clinical significance during the follow-up period of patients with differentiated thyroid cancer.Methods: Among patients who underwent total thyroidectomy and radioactive iodine treatment between 2008 and 2022 in a single center, 184 patients (23 male, 161 female) with Tg<1ng/ml and TgAb positive (> 60 IU/mL) at least once were targeted. ...

ea0011p79 | Clinical case reports | ECE2006

Ophthalmic presentations of Cushing’s syndrome

Ibrahim IM , Al-Bermani A , James RA

Introduction: Central Serous Retinopathy (CSR) is a condition characterized by the accumulation of sub-retinal fluid at the posterior pole of the fundus, creating a circumscribed area of serous retinal detachment. It is associated with increased levels of endogenous or exogenous glucocorticoids and has been described in patients with CushingÂ’s syndrome (CS).Here we report on two cases we recently managed in our unit, with central serous retinopathy ...

ea0070ep223 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

The relationship between milk and dairy consumption and obesity in children between the ages of 7–10

Mantar Ferhan , Yılmaz Bușra

Introduction: There is some evidence shows daily consumption of milk/dairy products prevents obesity and many diseases. Even in adulthood, the consumption of adequate milk/dairy products in childhood is protective of obesity. Therefore, balanced consumption of milk/dairy products is thought to prevent obesity or overweight, which is an important health problem nowadays. In our study, we aimed to determine whether there is a relationship between the consumption of milk/dairy pr...

ea0019p113 | Cytokines and growth factors | SFEBES2009

Adipokines and their influence on blood pressure in young women

Banerjee M , Vyas A , Pemberton P , Malik RA , Cruickshank JK

Introduction: Adiposity has been well known to influence blood pressure. Adipokines are peptides secreted from the adipose tissue. TNF-alpha and IL-6 are pro-inflammatory adipokines while adiponectin and leptin have been known to be influencing vascular function. The influence of adipokines on blood pressure is not yet known. Our hypothesis was that all adipokines positively influenced both systolic and diastolic blood pressure.Patients and methods: One ...

ea0011p56 | Clinical case reports | ECE2006

Acute myocardial infarction and Graves’ thyrotoxicosis

Chudleigh RA , Owen PJD , Bhattachrya S , Davies JS

The link between thyrotoxicosis and coronary artery disease is complex with associations between therapy and vasculitis, as well as thyroid hormone excess and coronary artery spasm described. We present a 37-year-old female with a one-year history of Graves thyrotoxicosis treated with Propylthiouracil, who presented acutely with chest pain and a left hemiparesis. Typical electrocardiography changes and elevation of Troponin T confirmed a recent myocardial infarction, and CT sc...

ea0011p632 | Neuroendocrinology and behaviour | ECE2006

Processing and sorting of pro-opiomelanocortin is an important checkpoint in regulating release of ACTH from secretory vesicles in pituitary cells

Warhurst A , Oliver RL , Davies RA , Pritchard LE , White A

Pro-opiomelanocortin (POMC) is endoproteolysed by prohormone convertase-1 (PC1) to ACTH within the secretory pathway in pituitary cells, where the regulation of ACTH release is essential for mediating the stress response. However POMC is present in the human circulation, indicating that not all POMC is processed. This suggests that regulation of trafficking and processing of POMC are important in determining ACTH release. To investigate this, we analysed steady-state release o...

ea0008oc15 | Neuroendocrinology and Reproduction | SFE2004

PGF2alpha -FP receptor signalling is a potential regulator of endometrial vascular function

Sales KJ , Williams ARW , Anderson RA , Naor Z , Jabbour HN

Prostaglandin F2a (PGF) receptor (FP) expression is up-regulated in neoplastic epithelial and perivascular cells in endometrial adenocarcinomas, indicating potential regulation of vascular function by PGF via the FP receptor. This study investigated the potential role of PGF-FP receptor signalling in modulating vascular function in endometrial adenocarcinomas.Endometrial biopsies were obtained in accordance with Ethics Committee guidance with ...

ea0065p162 | Endocrine Neoplasia and Endocrine Consequences of Living with and Beyond Cancer | SFEBES2019

Transient adrenal insufficiency in a patient with an insulinoma

Gill Georgina , Ra Amelle , Thu-Ta Pinky , Connolly Maya , Evans Paul , Srinivas-Shankar Upendram

A 45-year-old man with obesity (BMI 36 kg/m2) was admitted with a 12-hour history of headache and confusion and managed for viral meningitis. Treatment was discontinued after CSF viral PCR was negative. At presentation, he was hypoglycaemic with a capillary glucose of 1.6 mmol/l. Past medical history was not significant and there were no similar episodes previously. He denied taking insulin, other medications, illicit drugs or alcohol. Initial investigations reveale...

ea0065p379 | Reproductive Endocrinology and Biology | SFEBES2019

Infertility in a man with Sertoli cell-only syndrome and 47,XYY karyotype

Ra Amelle , Gill Georgina , Connolly Maya , Wilmington Rebekah , Evans Paul , Awasthi Anshu , Srinivas-Shankar Upendram

A 32-year-old man presented with a four year history of reduced libido, erectile dysfunction and inability to conceive with his partner. He went through puberty normally and had a normal sense of smell. Clinical examination revealed that he was 205 cm tall and normally virilised. Testicular volume was reduced, but the phallus was normal. Clinically, he appeared euthyroid and there were no features of hypercortisolism or growth hormone excess. Biochemical picture: prolactin 375...