Endocrine Abstracts

Background: Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors decrease the degradation of low–density lipoprotein (LDL) receptors, thereby increasing the removal of LDL particles from the blood and significantly reducing LDL cholesterol levels by an average of 65%. Blom et al. showed changes in vitamin E, adrenocorticotropic hormone (ACTH), cortisol, total testosterone, and estradiol in EVOLOCUMAB (PCSK9 inhibitor)–treated patients 1. Ther...

Introduction: Dyslipidemia (DL) in diabetic patients is frequently undertreated. Even when cLDL targets have not been met, treatment remains unchanged despite the availability of alternatives approaches. This is known as therapeutic inertia (TI).The aim of this study was to evaluate the prevalence of TI in lipid management among diabetic patients and to analyse associated factors and possible causes.Material and Methods: Retrospective, cross-sectional st...

Objective: Conflicting findings have been published regarding the pressure wave reflection and the arterial stiffness in young women with PCOS as opposed to the overt ab initio presence of endothelial dysfunction compared with controls which can be reversed six months after metformin administration. The aim of this study was to investigate arterial stiffness and wave reflections in young women with polycystic ovary syndrome (PCOS) with respects to the different weight...

Background: Studies show relationship between serum uric acid (SUA) and such diseases as type 2 diabetes (T2DM), hypertension (HT) and atherosclerotic cardiovascular disease (ASCVD). There is relationship both in hyperuricemia (HU), and high–normal values of SUA. Significance of this association is unknown; there are controversial data concerning HU role in patients with T2DM/CVD. The aim of the study was to assess SUA in T2DM patients with ASCVD.<...

Introduction: Asthma is often associated with various comorbidities, which may affect its clinical intensity and severity. The mechanisms of adult–onset asthma may include several metabolic and inflammatory components that are common to the other diseases such as obesity, metabolic syndrome, type 2 diabetes mellitus (T2DM), cardiovascular diseases and psychiatric diseases.Objectives: Assessment of asthma symptom control and QoL in a subgroup of ast...

Aims: To explore the correlations of BMI, waist circumference (WC), waist–to–height ratio (WHtR), waist–to–hip ratio (WHR) and body composition with levels of assymetric dymethylarginine (ADMA), endothelin 1(ET–1), N–terminal brain natriuretic pro–peptide (NT–proBNP), uric acid and calculated cardiovascular risks.Methods: 102 women and 67 men with type 2 diabetes on oral antidiabetic drugs participated. Ser...

Tocilizumab is an interleukin-6 receptor antagonist used in the treatment of rheumatoid arthritis (RA). It is known to induce remission and inhibit radiographic progression in RA. Tocilizumab may be administered either intravenously or subcutaneously. Its effect on lipid levels and the cardiovascular risk has not been fully investigated. The aim was to study the effect of tocilizumab administered either iv or sc on disease activity, lipid levels and cardiovascular risk in RA p...

Introduction: T2DM prevalence in Belarus is 3.489.5 per 100 thousand people, annual growth rate is 5–6%. STEPS study: in 2016–2017 the following risk factors prevailed: overweight and obesity (61.2%), dyslipidemia (36%), hypertension (50%); inactive lifestyle (78.2%). The study aim was to assess risk factors for metabolic disorders in a young healthy population. Objective. 253 people were examined: 22.1% of men and 77.9% of women under 40. Methods: We performed ant...

Aim: To study the distribution of epicardial fat in young people with type 1 diabetes mellitus using magnetic resonance imaging (MRI) technologies.Material and Methods: 60 patients (29 men, 31 women), aged 18 to 36 years old, with an experience of type 1 diabetes from 5 to 16 years old were underwent contrastive cardio MRI. Measurements of epicardial fat (EF) were carried out on basal (B), medium (M), apical (A) segments of the left (LV) and right ventri...

Aim: Netrin is classically recognized as a neural guidance cue that has been involved in various tissues including pancreas development. Because of Netrin’s tissue regenerative, angiogenic, and inflammatory suppression properties it could play a crucial role in the development of insulin resistance and type 2 diabetes. The aim of the current study is to investigate the relation between circulating levels of Netrin-1 and the glucose continuum.Method...

Objective: The aim of the study is to describe the prevalence of hyperlactatemia and changes in lactate concentrations in critically ill patients, and the associated mortality. Materials and methods: The study included 70 patients treated in the Medical Intensive Care Unit at the Clinical Center, University of Sarajevo, in a 6–month period. The following data were obtained: age, gender, reason for admission, Simplified Acute Physiology Score II, Ac...

Context: Weight reduction in obese patients with type 2 diabetes mellitus (T2DM) leads to hyperglycaemia improvement and reduces complications. Thus it is important to investigate the potential benefits of the use of different dietetic approaches on weight loss.Objective: To examine the efficacy of two different dieting methods on weight loss in patients with T2DM.Materials and methods: 30 participants with T2DM, 18 men and 12 wome...

Background: The aim of this study was to investigate whether both weight change and the background intakes of macronutrients modulate the association between dietary branch chain amino acids (BCAAs) and the risk of metabolic syndrome (MetS).Methods: This prospective study was conducted within the framework of the Tehran Lipid and Glucose Study. BCAA intakes were collected using a valid and reliable semi-quantitative food frequency questionnaire. MetS com...

Obesity is a polyetiological and incompletely studied disease. Recent publications link the special composition of the gut microbiota not only with obesity, but also with its metabolic profile1, 2. To study the characteristics of the gut microbiota in patients with different phenotypes of obesity, 37 patients were examined. In addition to determining the quantitative composition of the gut microbiota by the Real-time PCR method, all participants were determined by l...

Adipokine omentin is a connecting link between obesity and type 2 diabetes mellitus. It modulates insulin sensitivity of peripheral tissues and its secretion may change in the developed inflammation of adipose tissue at its excessive accumulation. Chemokine fractalkine is a marker of the development of inflammatory processes in the body. Objective: omentin and fractalkine contents in blood circulation depending on the degree if adipose tissue accumulation, waist circumference,...

Introduction: Type 1 diabetes can be associated with one or more other autoimmune pathologies in case of predisposing immune background.The aim of our study was to research the autoimmune pathologies associated with type 1 diabetes and to describe the clinical and biological characteristics of this population.Patients and Methods: This is a retrospective descriptive study including 26 patients with type 1 diabetes with at least one...

Background: Attendance and active participation in diabetes school classes is an important element in disease management. It has been noted that self–learning and self–help predetermine the clinical outcomes of diabetes and the quality of life of patients.Aim: To evaluate the awareness of patients with type 2 diabetes (T2D) about their disease.Materials and methods: 45 patients with T2D were included. The survey contain...

Bulgaria is also among the countries with national data on the prevalence of Diabetes published in the Diabetes Atlas of the International Diabetes Federation’2019, but did not provide data on the incidence of Hyperglycemia in pregnant Bulgarian women.Purpose: The Bulgarian Society of Endocrinology organized and conducted screening for Hyperglycemia in pregnant women in 2019.Material and Methods: 547 pregnant women from 10 re...

Introduction: Fasting during Ramadan is a pillar of Islam. The majority of diabetic patients at risk, practice it even if they are exempt. This practice shifts energy and hydration in the evening and reverses the sleep–wake rhythm. The aim of this work is to study the effect of fasting during the holy month on the sleep–wake clock in fasting diabetics.Patients and Methods: As part of an overall management of accompagnimant for our diabetic pa...

We report the case of a 28-year-old Emirati lady with type 1 diabetes (weight 51 kg, BMI 20.82 kg/m2) diagnosed at 3 years of age who presented to our centre with problems at her insulin injection sites. She had poor glycaemic control and her diabetes was complicated by retinopathy; other past medical history included vitamin D deficiency. All her seven siblings had diabetes and were on insulin; both parents had type 2 diabetes.In 2017, she wa...

Aim: Atherosclerotic cardiovascular disease, defined as myocardial infarction (MI), cerebrovascular accident (CVA), peripheral artery disease (PAD), is the main cause of morbidity and mortality in people with diabetes mellitus (DM) and the main cause of health expenditure in these patients.Like in other parts of the world, a prospective study of the Asturian population showed that the mortality risk due to cardiovascular diseases was significantly higher...

Aims: Maternal dyslipidemia during pregnancy is more serve in GDM women compared with non–GDM women. The occurrence of postpartum hyperglycemia is associated with increased lipid profiles. The purpose of this study was to evaluate the relationship between lipid changes and early postpartum abnormal glucose metabolism (AGM) of women with prior GDM history.Methods: 395 patients with a history of GDM who had a postpartum OGTT were included in this ret...

Introduction: Due to the association of hyperuricemia with conventional cardiovascular risk factors, it is difficult to determine whether uric acid is an independent risk factor for the development of renal failure. The objective of this study was to investigate the correlation between uric acid levels and kidney function in type 2 diabetics.Methods: This was a descriptive cross–sectional study carried out from March to September 2017 on 122 diabet...

Introduction: Fasting the month of Ramadan is practiced by more than one billion Muslims worldwide, including type 2 diabetic patients. Its effects on body composition and body weight in type 2 diabetic patients are controversial.The objective of our study was to assess the evolution of anthropometric parameters as well as the body composition in type 2 diabetic patients who fasted the month of Ramadan.Methods: We conducted a prosp...

There are three main types of diabetes mellitus: type 1 diabetes mellitus (T1DM), type 2 diabetes mellitus (T2DM) and gestational diabetes, with the first two types making about 99% of cases.According to its nature, type 1 diabetes mellitus (T1DM) is considered as a typical autoimmune disorder characterized with specific autoantibodies. Immunological markers of the diabetes mellitus onset can be found not only in T1DM with its specific clinical picture, ...

Introduction: Besides its role in calcium homeostasis, vitamin D (VD) has an important immune mudulation effect. However, its role in autoimmune diseases such as type 1 diabetes is under discussion. In this study, we aimed to assess VD status in children and adolescents with type 1 diabetes mellitus (T1DM).Material and Methods: This is a retrospective descriptive study realized at the endocrinology–diabetology department of OUJDA’s Mohammed V...

Aim: To determine the effect of socioeconomic and educational status on metabolic control in T2D patients in Republic of Srpska (RS)Subjects and method: This is a cross–sectional study of 1088 subjects aged 18 or higher who were randomized from primary care physicians’ T2D diabetes registries. Socioeconomic, educational, anthropometric and metabolic characteristics of T2D patients were analyzed.Results: Highest proporti...

Aim: Chronic diabetes complications are the main cause of patients’ mortality, life span shortening and decreased quality of life. Aim of this study is to determine the incidence of chronic diabetic complications and their association with glucoregulation quality and antihyperglycemic treatment in diabetic patients in Republic of Srpska. (RS).Method: This cross–sectional study included 1037 diabetic patients in RS. Immuno–inhibition tes...

Purpose: To study the state of the microvasculature and tissue metabolism (according to the dynamics of the FAD and NADH coenzymes) using laser Doppler fluometry (LDF) and laser fluorescence spectroscopy (LFS) in patients with diabetes mellitus.Materials and methods: To implement the combined use of LDF and LFS methods, the Laser Diagnostic Device LAZMA ST was used (registration certificate of Roszdravnadzor No. RZN 2017/5844 of June 08, 2017).<p cla...

Methylglyoxal (MG) damages arginine protein residues, inhibits enzymes, disrupts insulin signal transmission, and plays a key role in the development of insulin resistance and hyperglycemia. High glucose levels cause an increase in glycation and methylglyoxal formation. Glycation is the main cause of protein damage, leading to the production of free radicals and causing inflammation.The purpose of the study: To Identify the relationship of methylglyoxal ...

Introduction: Most cases of Diabetes mellitus (DM) in children and adolescents are autoimmune (type 1), even though recently there has been an increase in type 2 DM mainly due to the increased prevalence of obesity in this age group. However, rarely DM could be attributed to other causes such as MODY. An extremely rare cause is the hereditary pancreatitis due to activating mutations of the PRSS1 gene. This gene encodes an enzyme, cationic trypsinogen, whose hyperactivity leads...

Hyperglycemia in a 27–year–old woman without obesity was found in the first trimester of her third pregnancy in 2015 (fasting plasma glucose – 5.8 mmol /l). Gestational diabetes was established and insulin was initiated in basal–bolus regimen. After delivery the blood glucose was normal due two months then hyperglycemia increased to 15 mmol/l. Metformin and glimepiride were prescribed within effect. Then insulin detemir (8 U/day) was prescribed with DPP...

Background: Different screening programs recommend starting active search for type 2 diabetes (DM2) at age from 35 to 45. This difference comes from variety in structure of population and weight of age as a risk factor, and also has economical background.The aim of our study: Was to find out the most acceptable cut–off age for DM2 screening in Uzbekistan.Material and Methods: We analyzed results of type 2 diabetes screening i...

Background of the study: There is lack of data in the Czech Republic on iodine status in patients suffering from diabetes mellitus type 1 (DM1) considered to be at risk of iodine deficiency.Subjects and methods: A total of 54 males and 51 females ‒ median (25th, 75th percentile): age (years) 42 (31, 55); BMI 25.9 (23.3, 29.7); HbA1c (mmol/mol) 61 (51.2, 71.0) treated for DM1 were included in this cross–sectional study. In addition to iodine s...

Introduction: Apart from genetics, autoimmunity has been implicated in pathogenesis of diabetes mellitus (DM). Further the role of vitamin B12 levels in diabetic immunomodulation is controversial. In this context, we set out study the role of Pro– inflammatory cytokines in DM with or without vitamin B 12 deficiency in South Indian population.Material and Methods: This prospective case–control study was conducted on diabetes mellitus patients....

Background: Psoriasis is a common chronic, inflammatory skin disease that may exhibit a variety of clinical manifestations. Psoriasis has also been identified as a multisystem chronic inflammatory disorder associated with multiple comorbidities. Recently has been reported a role for vitamin D in the pathogenesis of different skin diseases, including psoriasis.Aim: The objective of this study was to measure the serum level of vitamin D in patients with ps...

Introduction: Cushing’s disease is diabetogenic due to the insulin resistance generated by the stimulating effect of glucocorticoids on neoglucogenesis and hepatic glycogenolysis.GoalAim of our work is to study the frequency and characteristics of diabetes mellitus during Cushing’s disease.Material and Methods: Retrospective study of a sample of 100 patients collected between (January 1983 –...

Background and aims: Obese people have more risk for hypertension, Diabetes mellitus and cardiovascular disease. Obesity is a major health issue globally. So our aim is to estimate the prevalence of obesity and abdominal obesity in adult patients.Materials and methods: In our study total 150 adults (> 20 years of age) patients were included. They were selected randomly & examined for BMI (body mass index) and WHR (waist to hip ratio).<p class...

Background: Obesity is an excess accumulation of adipose tissue in the body, characterized by impaired lipid and carbohydrate metabolism with subsequent pathological changes. The purpose of this study was to investigate the functioning of the reproductive system, metabolic and immunological status in women of reproductive age with obesity and overweight.Methods: We examined 110 women of reproductive age including 60 patients with obesity (group I), 25 ov...

Introduction: Bariatric surgery is the treatment which has shown the most important effectiveness in terms of weight reduction, improvement of co morbidities, quality of life and mortality on the long term, in the case of massive obesity and obesity associated with co–morbidities. The purposes of our study: clarify the place of bariatric surgery in the treatment of obesity, define the criteria of selections of patients.Material and Methods: It&#821...

In the current study, we aimed to illustrate determinants of VDR gene expression in visceral and subcutaneous adipose tissues among obese and morbidly obese adults. We gathered visceral and subcutaneous adipose tissues during an elective abdominal surgery form 33 morbidly obese (body mass index (BMI) >40 kg/m2) and 23 obese (BMI = 30–40 kg/m2) participants who were free of diabetes. Before the surgery, dietary intake, physical activity, anth...

Background: By focusing on nutrition transition in the Middle East and North Africa, this study aim to investigate the general structure and secular trend of dietary patterns extracted from the Tehran Lipid and Glucose Study (TLGS) and adherence to these dietary patterns among Iranian population from 2006 till 2017.Methods: We investigated on four examination surveys of TLGS including survey 1 (2006–2008), survey 2 (2009–2011), survey 3 (2012...

As known, the number of obese people in the world exceeds 50% of the total population. Тo search the causes of obesity development many researchers pay attention to metabolites of intestinal microflora among which the main ones are short–chain fatty acids (SCFA): acetate (C2), propionate(C3), butyrate(C4). Hormones of food behavior produced by visceral adipose tissue (leptin) and cells of the gastrointestinal tract (ghrelin) also play an important role in the devel...

Background: The aim was to establish the features of metabolic disorders and the state of the renin–angiotensin–aldosterone system (RAAS) in obese patients with true and pseudo–resistant arterial hypertension (AH).Material and Methods: The study included 200 patients with uncontrolled AH and obesity. Patients were initially prescribed dual antihypertensive therapy. Those patients who did not reach target blood pressure (BP) levels after...

In recent years, there has been an increase in patients with metabolic syndrome (MS), which is an urgent medical problem. The severity of the clinical manifestations of MS affects the quality of life of patients, while reducing physical and mental health. Obesity leads to anxiety and depressive disorders, neurosis–like conditions, which contributes to a worsening prognosis of the underlying disease.The aim of the work was to assess the level of anx...

Obesity and type–2 diabetes (T2D) represent a global health crisis. However, only a few, and often sub–effective pharmacological tools are available to treat these disorders. Though beneficial for glycemic control, GLP–1 receptor (GLP–1R) agonists show scarce weight–lowering and insulin–sensitizing efficacy.New molecules able to selectively block the activity of the cannabinoid receptor type–1 (CB1R) in periphera...

Background: NAFLD(non–alcoholic fatty liver disease) includes; non–alcoholic fatty liver(NAFL), non–alcoholic steatohepatitis (NASH) and its complications (fibrosis, cirrhosis and hepatocellular carcinoma). These diseases are currently the most common cause of liver disease in western countries, due to the obesity and DM2 epidemic. There are scores that determine the risk of liver fibrosis in a non–invasive way.Aims: To determine ...

Introduction: In Brazil, most patients referred to bariatric surgery are women. The literature indicates the occurrence of gender differences in body composition and body image perception.Aim: To study body image perception and its relationship with body composition in Brazilian bariatric patients.Methods: A total of 140 patients were evaluated using the Stunkard Figure Rating Scale (SFRS) and bioimpedance. Image dissatisfaction an...

Background: The frequency of prediabetes is increasing as the prevalence of obesity rises worldwide. Hyperglycemia, insulin resistance, inflammation and metabolic derangements associated with concomitant obesity cause endothelial dysfunction in prediabetics, leading to increased risk of cardiovascular and renal disease.Objective: To get a general perspective on the complex relationship between cardiovascular diseases onset, and pre–diabetes<p c...

Insulinoma represents one of the most encountered neuroendocrine tumors, but only 4–14% is malignant. The diagnosis is suggested by high serum insulin levels during spontaneous or induced episodes of hypoglycemia and often invasion of lymph nodes and liver metastasis. A 55–year–old female was referred to our center after an episode of hypoglycemia during strumectomy for multinodular goiter. Further questioning revealed few years of Metformin treatment for hyp...

The lifetime risk of pancreatic cancer for the average individual without a family history of pancreatic cancer is approximately 1%. Individuals with a family history of pancreatic cancer are at an increased lifetime risk for developing pancreatic cancer. This risk is likely higher for individuals from a family with FPC. The following cancer risk estimates are generalized and should be interpreted with caution since the actual risk for each individual may be different:We recei...

Background: We present an interesting case of a 56 year old male who, during pre–operative work up, was found to have a very low HbA1C 3.1% (10 mmol/mol). The patient was also noted to have mild thrombocytopenia, raised bilirubin and alanine aminotransferase and moderate splenomegaly on CT scan, with otherwise normal appearance of remaining abdominal viscera. His past medical history included alcohol excess (60–80 units/week), he was not diabetic and was taking Asp...

Introduction: Diabetic ketoacidosis (DKA) is characterized by the triad – ketonemia, metabolic acidosis and hyperglycemia. It is typically associated with type 1 Diabetes Mellitus (T1D) and the most common culprits are infections and poor therapeutic compliance.Clinical Case DescriptionThe present case deals with a 25–year–old female patient, with T1D diagnosed in 2008, without microvascular or macrovascular compl...

Background: Hajj is one of the five pillars of Islam and is a must–do for all adult Muslims once in their life provided they are able to do it. It’s estimated that pilgrims with diabetes could exceed 220000/year. Patients with diabetes are at a great risk of illness due to the nature of the disease and the altered daily routine (overcrowding, inadequate nutrition, poor access to drinking water, hot weather and physical exertion).The primary aim of this study is to ...

Background: Otogenic cerebral thrombophlebitis is a rare intracranial complication of otitis media in the modern age of antibiotic treatment, but it is potentially a dangerous complication spatially in immune depressed patients with diabetes.Aim: To discuss the clinical features of this complication and to analyze the impact of diabetes on its evolution as well as the management of this entity.Methods: We conducted a retrospective ...

Introduction: The American Diabetes Association (ADA) recommends an annual foot screening of patients podiatric risk for ulceration and amputation, to take effective preventive measures. However, the gradation of the podiatric risk remains insufficient, particularly in Tunisia, where epidemiological references remain missing. The aim of this study was to classify a population of diabetic patients according to the grade of podiatric risk by referring to the recommendations of t...

Introduction: Diabetic foot is a major health problem for people with diabetes mellitus. It can cause serious complications leading to lower extremity amputations. The aim of this study was to determine the prevalence and risk factors of foot complications among diabetic patients in Mahdia, Tunisia.Methods: Detail history and examination including neurological and vascular assessment were performed in 150 patients with diabetes mellitus attending Tahar S...

Introduction: Testosterone levels are frequently low in men with type two diabetes mellitus, and sexual symptoms are a prominent presenting feature for these men.Objectives: The aim of this study was to determine the frequency of hypogonadism and related risk factors among Tunisian patients with type two diabetes mellitus and erectile dysfunction.Methods: This cross–sectional study included a total of one hundred and thirty c...

Introduction: Pathological features of T2DM – change in β–cell mass, increased intestinal glucose absorption, glucagon secretion, gluconeogenesis, enhanced catecholamines, insulin resistance – features of hyperthyroidism as well. It is known that Insulin Like Growth Factor Binding Protein (ILGFBP) is related to high insulin (possible asymptomatic hypoglycemia) as well to function and growth of the thyroid, that’s why there is increased risk that pa...

Introduction: PCOS is the most common endocrinopathy in adolescents and young women. Insulin–resistance and hyperinsulinism are its primary mechanisms, which explains the frequency of its association with type 2 diabetes. But not many studies have been interested in the association between PCOS and type 1 diabetes.Patients and Methods: Two type 1 diabetes patients have been included in this study, aged respectively 17 and 16. The first patient had ...

Aim: The levels of serum Selectins (P and E–Selectin), membrane potential and antioxidant vitamins were determined in diabetic patients attending General Hospital Owerri, Nigeria.Materials and methods: A case control study involving 600 persons living with diabetes between the ages of 20 and 60 years attending General Hospital Owerri. Also, 600 apparently healthy persons within the ages of 20 and 60 years served as control. Fasting venous blood was...

Introduction: Necrotizing otitis externa (NOE) is an invasive infection. It may present with a variety of clinical findings. The most common symptoms are purulent otorrhea and exquisite otalgia resistant to analgesics. Diabetics are susceptible to microangiopathy that dulls pain perception thus predisposing them to severe complications of inctious disease.Materials and methods: We reported ten cases of complicated necrotizing otitis externa in diabetic p...

Rehabilitation of comorbid patients after acute myocardial infarction (AMI) with concomitant diabetes mellitus type 2 (DM2) and obesity requires application of personalized medical programs involving non–pharmacological physical methods and effective pharmacological therapy of DM2. The aim of the clinical case presentation is a description of the experience of complex medical rehabilitation of the middle–aged woman in the early period of AMI on the background of DM...

Introduction: Acute hemichorea due to hyperglycemia has been reported in subjects with type 2 diabetes, type 1 diabetes, and a rare type of diabetes, maternally inherited diabetes and deafness. This condition was generally subsided after adequate glycemic control, and the recurrence of hemichorea was rarely reported.Case report: We comprehensively reviewed clinical presentation and course of hemichorea in five elderly patients with type 2 diabetes (four ...

Objective: Statins are the mainstay of treatment for patients with familial hypercholesterolaemia (FH). The purpose of this study was to systematically investigate and meta–analyze the best available evidence from randomized–controlled trials (RCTs) regarding the efficacy and safety of statins in children and adolescents with FH.Methods: A comprehensive search was conducted in PubMed, Scopus and Cochrane, up to July 10, 2019. Data were expres...

Background: Type 2 diabetes (T2DM) is associated with increased risk of cardiovascular (CV) complications. Although evidence suggest SGLT–2 inhibitors and GLP–1 receptor agonists to have a protective effect on CV outcomes they are still not available as a second–line therapy in Lithuania because of costs.The aim: To examine the risk of hospitalization for CV events associated with diabetes therapies in patients with T2DM.<p class="a...

Matrix–GLA–protein ( MGP), independent of its posttranslational modification(s), has been associated with bone parameters and cardiovascular risk in patients with and without type 2 diabetes mellitus (T2DM). We investigated whether uncarboxylated, dephosphorylated MGP (uc–dp MGP), total MGP or both are associated with anthropometric and cardiovascular parameters such as carotid to femoral pulse wave velocity (PWV), intima–media thickness (IMT) and relat...

Introduction: Celiac disease is an autoimmune disease triggered by gluten frequently associated with other autoimmune diseases, among which is type 1 diabetes first.Objectives: The objectives of our study are:– To determine the serological prevalence of celiac disease (CD) in patients with type 1 diabetes (DT1)– Compare the clinical and biological characteristics of seropositive and seronegative p...

Introduction: One of the autoimmune non–diabetic hypoglycemia (NDH) causes is the formation of antibodies to insulin (AB–IRI) or Hirata disease (HD).Objectives: To determine the prevalence of AB–IRI level increasing in patients with suspected NDH of various genesis and in healthy individuals.Methods: 96 patients aged 18–80 years with suspected NDH were included in prospective study. In all patients we determ...

Distinguishing type 1 from type 2 diabetes mellitus (DM) depends on clinical presentation, titers of antibodies and requirement for insulin therapy. Need for insulin per se is not a major difference between those two types. We measured the presence of antibodies for glutamic acid decarboxylase (GAD), islet–cell antibodies (ICA), insulinoma–associated protein 2 (IA–2) and the level of C–peptide in a group of 10 patients whose diagnosis of type 2 DM was e...

Introduction: After the fast of the month of Ramadan, the lipid balance of the elderly patients with diabetes can be modified. The aim of our study was to describe the evolution of the parameters of the lipid balance after the fast of Ramadan in a population of elderly diabetic subjects.Patients and methods: This is a prospective evaluative study conducted in a population of 20 patients with type 2 diabetes aged over 65 years. This population had benefit...

Introduction: Insulin therapy ( IT) in type 2 diabetes( T2D) is an integral Pharmacologic Approache because of the progressive nature of the disease. Insulin improves glycemic control and reduces the risk of microvascular complications. It’s however associated with weight gain as a side effect which promotes insulinoresistance and cardiovascular morbi–mortality.In this work we evaluated long–term weight gain in insulin–treated pat...

Introduction: Few studies have examined the adherence to anti–diabetic treatment in patients with diabetes during the fast of the month of Ramadan.The aim of our study was to describe the adherence to antidiabetic treatment in patients with diabetes before and during the fast.Patients and Methods: This is a descriptive and analytical study carried out on 140 diabetics who have fasted the month of Ramadan. The risk stratificat...

Objectives: Semaglutide was approved for the treatment of T2DM patients with a body mass index (BMI) > 30kg/m2 by the Spanish National Health Service in May 2019. We evaluate clinical outcomes of patients on previous treatment with any another GLP1–RA that switch to Semaglutide.Material and Methods: Retrospective analysis. Sixty–five T2DM patients were included. Demographic data, anthropometric, systolic blood pressure (SBP), d...

Background: Type 1 diabetesmellitus (T1DM) isthe most widespread metabolic/endocrine condition among children/adolescents in Georgia. T1DM patients aged 0–18 yrs are treated both in– and outpatiently. In 2015–2019 totally 533 patients were hospitalized, 211 of them had fresh T1DM. Special attention is paid to interactive diabetes education (IDE) of patients/their caregivers, thatis very important for adequate diabetes management. IDE is initiated from the day...

Treating Syrian refugees with diabetes, hypertension and Hypothyroidism in Azraq refugee camp, Zarqa, JordanBackground: Arabian Medical Relief under the donation of UNHCR has been providing primary health care for Syrian refugees at Village six in Azraq refugee camp, Zarqa, Jordan, their services include non–communicable diseases(NCDs)management, apart from other health services. The objectives of this study were to describe the method of care and ...

Background and Aim: SGLT2 inhibitors are relatively new class of medications in the management portfolio of type 2 diabetes (T2DM). Despite their late introduction, they have gained substantial up–gradation in the treatment algorithm as suggested by various international bodies. Remogliflozin is an SGLT2i licensed in India and several other countries for the management of T2DM. We studied the effect of Remogliflozin on serum uric acid (SUA) levels in subjects with type 2...

Purpose: Diabetic Foot Ulceration (DFU) is common problem throughout the world and resulting in major economic consequences for the patients and country. We aim to describe estimated cost of illness between patients with DFU in southern Turkey.Methods: A total of 148 (F = 55, M = 93) patients with DFU were included in this retrospective study. We also included more than one admission of the patients with DFU. Patients characteri...

It has been shown that miR-107 regulates insulin sensitivity, but its status in severe insulin resistance (IR) patients has not been established. In this study, we investigated the expression of microRNA-107 in the sera from patients with clinically severe IR and its relationships with metabolic characteristics.Methods: The expression of microRNA-107 was detected in the sera of 30 clinically severe IR patients and 24 gender and age-matched control group ...

Introduction: Primary biliary cirrhosis and autoimmune hepatitis are two chronic liver diseases. An overlap of the characteristic signs of these two conditions, determining an ‘Overlap syndrome’ can be seen. Type 1 diabetes can be associated with this syndrome due to the autoimmune predisposition.Observation: We report the case of a young type 1 diabetic patient referred to our service for additional management of a glycemic imbalance. This i...

Aims: The aim of our study is to assess the efficacy of lifestyle modification and picolinate chromium intake in preventing diabetes mellitus type 2 (DM 2)Materials and methods: The study included 100 patients (69 m 258 f) 25–65 years with impaired glucose tolerance (IGT) and newly diagnosed DM 2. Patients were divided into 2 groups matched by age, weight, body mass index (BMI), waist-to-hip ratio (WHR). Research group included 54 patients who carr...

Introduction: One of the often-discussed topics in the management guidelines for Type 1 Diabetes Mellitus (T1DM) is the ideal time gap that should exist between patient check-ups. A period of three to six months is usually recommended, which sometimes is difficult to achieve due to the high number of patients. But to what extent does the time gap between appointments in the follow-up of T1DM patients affect their diabetes’ control?Objectives: To kn...

Introduction: Although a strong association between diabetes mellitus and carcinogenesis is suggested, their relationship is still debated. Diabetic ketosis is an acute metabolic complication caused by absolute or relative insulin deficiency. It is rarely a revealing condition of a malignant tumor.The aim of our study was to determine clinical and paraclinical particularities of patients with malignant tumors revealed by a diabetic ketosis.<p class="...

Introduction: Ketosis-prone diabetes or Flatbush diabetes has been recognized as a clinical entity since 1984. Is characterized by diabetic ketosis or ketoacidosis occurring soon after the onset of hyperglycemic syntoms (usually poyiuria, polydipsia and weight loss are present for less than 4 weeks). Unlike the insulin dependence seen in type 1 diabetes, after a few weeks (usually 2 to 12 weeks), insulin requeriments decrease, and approximately 70% of patients achieve remissio...

A 54-year-old gentleman presented to his GP in July 2019 with significant weight loss, polyuria and nocturia for two to three months. His HbA1c was 78 mmol/mol. He was diagnosed with diabetes and started on Metformin 500 mg BD. Upon consultant review in September 2019, he reported a 26 kg weight loss over the preceding four years, much of which was apparently intentional, and right abdominal discomfort. His paternal grandmother died of pancreatic cancer, as did his paternal au...

Introduction: Diabetes is the leading cause of end-stage renal disease in Europe (12 to 30%). In the United States, it is the cause of more than half of the cases of this disease. Renal disease is a cardiovascular morbidity and mortality preacher which is three times more common in diabetic patients with diabetic nephropathy (DN). The aim of our study was to describe the factors of cardiovascular risk associated with ND in a group of type 2 diabetes (T2D) Tunisians.<p clas...

Background: Anemia is a common finding in patients with diabetes mellitus which increases the progress of the diabetic complications. There are several factors which cause anemia out of renal failure in diabetics. In this study, we aimed to investigate the frequency of anemia and factors that decreases hgb levels in diabetic patientsMethods: This retrospective study includes 207 diabetic patients that were hospitalized between january 2019 and january 20...

Introduction: Charcot foot is a painless progressive osteoarthropathy of one or more joints due to an underlying neurological lesion, leading to deformities of the foot by the non-infectious destruction of bones and joints.The interest of this observation is to show on the one hand the role that the education of diabetics plays in the early diagnosis of Charcot foot and on the other hand the need for a multidisciplinary team in the care of the foot of Ch...

Background and aims: Diabetes mellitus (DM) is a chronic, metabolic disease that is spreading rapidly around the world. Various studies have shown the association between DM and oral health. The aim of this study was to evaluate the knowledge patients with diabetes have regarding the impact of diabetes mellitus on oral health; the role of oral hygiene care and dentists follow up.Methodology and methods: The survey research was taken in 79 Albanian patien...

Objective: Diabetic foot complications are a main cause for hospital admissions and spending for patients suffering from T1DM or T2DM. The purpose of this study was to identify and compare possible risk factors for patients suffering from such issues.Methods: We conducted a retrospective observational study analyzing data from observation charts of 324 patients, diagnosed with T1DM or T2DM as well as various foot issues, evaluated between January 2015 &#...

Introduction: Hypoglycemia is common in diabetic patients as an adverse effect of their medication. A minority of hypoglycemia occurs in non-diabetic patients. This spontaneous hypoglycemia defined by the Whipple’s triad results from organic (non-reactive) or functional (reactive) causes, and in few cases, a factitious hypoglycemia, posing an etiological problem. The aim of our study was to assess clinical and biological features of non-reactive hypoglycemia in non-diabe...

Background: Prader-Willi syndrome (PWS) is a genetic neurodevelopmental disorder characterized by marked hyperphagia and morbid obesity, together with hormone deficiencies, abnormal behaviour in relation to food (obsessive thinking, food foraging, stealing, etc.). Veins in patients with PWS are difficult to find due to obesity and probably to generalised hypotonia including venous tone. Since treating a patient with PWS often requires the acquisition of blood samples, an exper...

Context: Postoperative central diabetes insipidus (PDI) is one of the most common complications of surgical treatment of pituitary adenoma, temporary or permanant. The diagnosis of PDI was suspicious in some occasions and inappropriate prescription of antidiuretic hormone was harmful. Generally, high level serum uric acid (HUA) was a clue for central diabetes insipidus, but we did not know its role for the brain postoperative subjects. As we know, the food intake and health co...

Introduction and objectivesType 1 diabetes mellitus (T1DM) is a chronic disease with potential consequences for patients, relatives and ultimately for the healthcare system. The objective of this study is to report the incidence of DM1 in our area as well as assess the characteristics of the patients at the time of diagnosis.Material and Methods: Retrospective descriptive study. Data was collected through the registration of new di...

Objective: To study the dynamics of cytolysis and carbonyl stress (methylglyoxal (MG)) in patients with type 2 diabetes mellitus (DM2) and non-alcoholic fat disease liver (NAFLD) on the background of various hypoglycemic therapy.Materials and methods: The study included 48 patients, 53.8 ± 11.14 years, with SD2 and NAFLD and 20 people in the control group. Viral hepatitis was excluded, toxic and drug-induced liver injury. Anthropometric researc incl...

Glycation is due to the ability of glucose to form irreversible chemical compounds with amino groups of lysine and arginine – methylglyoxal (MG).Material and Methods: 98 patients with NAFLD and 52 patients with NAFLD were examined. Diabetes 2-type, and 22 healthy volunteers. Age 57.3 ± 5.2 years. BMI 34.85 ± 1.79. The diagnosis was established on the basis of laboratory data and examination results. The level of LPO was determinedby the c...

Background: Diabetes mellitus is the commonest endocrinopathy, Worldwide. Inspite of its commonality, the genetic basis of etiopathogenesis and pathophysiology are ever evolving and enigmatic. Amongst the protean genetic variations, cubulin gene and megalin gene mutations in diabetes are important in dictating genotype—phenotypic correlations and natural clinical course of diabetes. The genetic studies in this area are especially very sparse from Indian sub-continent. In...

Background: Type 2 diabetes mellitus (DM) is probably one of the non-communicable diseases with raised levels of glucose in the blood due to insulin efficacy. The aetiology of disease combines both genetic and lifestyle or environmental factors. (GWAS) studies have been identified CAPN10 (SNP-19), FTO (rs-9939609), MTHFR (rs1801133) and PPARG (rs1801282) genetic polymorphism with susceptibility to T2DM. The susceptibility will increase by independent risk of genetic polymorphi...

Background: Wolfram syndrome (WS) is an autosomal recessive neurodegenerative disorder characterized by Diabetes Insipidus, Diabetes Mellitus (non-autoimmune), Optic Atrophy, and Deafness.We report the case of a patient sent to the physical and rehabilitation department to manage urinary disorders and for whom the diagnosis of WS was retained.Case report: A 24-year-old female patient, with history of diabetes mellitus type I from t...

Introduction: There is some evidence shows daily consumption of milk/dairy products prevents obesity and many diseases. Even in adulthood, the consumption of adequate milk/dairy products in childhood is protective of obesity. Therefore, balanced consumption of milk/dairy products is thought to prevent obesity or overweight, which is an important health problem nowadays. In our study, we aimed to determine whether there is a relationship between the consumption of milk/dairy pr...

Introduction: Ceylon cinnamon (CC) has shown its interest in insulin resistance, type2 diabetes and weight loss. In this study, we aimed to evaluate the effects of CC on anthropometric indices in patients with polycystic ovary syndrome (PCOS).Methods: We performed a prospective interventional study, including 13 patients with PCOS, diagnosed according to the Rotterdam criteria, patients having received neither diet education nor Metformin. At T0 all our ...

Introduction: The efficacy and safety of bariatric surgery (BS) are well documented, but data in our region is lacking.Aim: Analyze the long term effect of BS on obese patients in a single district hospital. Primary outcomes: –weight change 5–10 years post BS; –patient satisfaction. Secondary outcomes: weight reduction according to type of surgical procedure, sex, public/private hospital; mortality, complications....

Introduction: Obesity and metabolic disturbances constitute an important health problem in elderly women. Due to the multifactorial background of these disorders, assessment of the interaction between risk factors is still a significant element of prevention and health promotion in this group. Studies have shown, inter alia, the relationship between low physical activity and vitamin D deficiency with obesity and its complications. Furthermore vitamin D influences production of...

The fat tissue inflammation and insulin resistance formation are common in obesity and type 2 diabetes mellitus. The tumor necrosis factor–α (TNF-α), a pro-inflammatory cytokine, was found to be a key one in onset and progression of insulin resistance, blocking the insulin signaling pathway and hampering the gene expression of GLUT4, the intracellular insulin-regulated glucose transporter in body tissues. Rise in the TNF-α concentration in blood serum is b...

The liver produces and secretes sex hormone–binding globulin (SHBG), which transports sex steroids and regulates their access to tissues. Body mass index is a major determinant SHBG concentration in the blood of men and women. Low plasma SHBG levels are associated with obesity and predict the development of type 2 diabetes and cardiovascular disease. The reason why obese individuals have low circulating SHBG has been attributed to hyperinsulinemia, but no mechanistic evi...

Introduction: High blood pressure during pregnancy is associated with various maternal and fetal complications. This risk further complicates the pregnancy of diabetic women.Patients and Methods: We carried out a longitudinal retrospective study including one hundred pregnant women with type 1 and type2 diabetes, recruited from the patients monitored at the national nutrition institute during the period from January to December 2016.<p class="abstext...

Background and aims: Diabetes is an endocrinological disease with high incidence and important complications. Studies indicate that by 2030, diabetes will affect approximately 366 million people around the world. Neopterin is produced by activated monocyte-macrophages with the induction of interferon gamma and it is accepted as a biomarker of immune activation. Elevated neopterin levels in biological fluids can be observed in neurological, cardiovascular and autoimmune disorde...

Background: The number of patients with type 2 diabetes with mental problems will increase in the coming years1. The fight against diabetes cannot be reduced only to the competent prescription of medications, but should be carried out comprehensively taking into account numerous barriers.Aims: The objective of this study was to investigate prevalence and impact of anxious and depressive reactions among persons living with type 2 diabetes in Be...

Type 2 diabetes mellitus (DM2) is often associated with obstructive sleep apnea (OSA), according to the literature. Current approach in choosing the hypoglycemic therapy is based on individualization, but do not take into account the effect on OSA. The research purpose: to evaluate the effect of various hypoglycemic agents on the characteristics of OSA in patients with type 2 diabetes.Materials and methods: The study included patients with OSA and DM2, t...

Introduction: Fasting during Ramadan is an obligatory practice for adult Muslims. Although exemptions exist in certain conditions,including diabetes, the majority of diabetic patients fast despite this concession with the risk of complications mainly hypoglycemic accidents. The aim of this study is to establish the relationship between hypoglycemic accidents and drug treatment, therapeutic education, clinical and biological characteristics of tunisian diabetic patients during ...

Aim: Current guidelines for type 1 diabetes mellitus (DM1) suggest a therapeutic goal for glycosylated hemoglobin (A1c) of < 7.0% in adults and < 7.5% in children and adolescents, while emphasizing the importance of managing dyslipidemia. We aimed to record the achievement of therapeutic goals in DM1 patients followed-up in a Greek tertiary center.Methods: Data were included from DM1 patients who had visited the Department at least once in the pr...

Introduction: Clinical trial data demonstrate improved glycemic control in individuals with type 1 diabetes (T1D),especially, reduction of time in hypoglycaemia with flash glucose monitoring (FGM);however real-life conditions can modify this scenario.Aim: To examine real world use and glycemic control following a standardized initiation process of FGM.Methods: Individuals aged 18 years or older with T1D were prospectively recruited...

The incidence of type 1 diabetes mellitus (T1DM) is rising. The demands of daily management, blood glucose variability and potential complications pose challenges in management of T1DM.The aim of this study was to determine the clinical and metabolic profiles of T1DM patients attending Midland Regional Hospital Portlaoise diabetes service in 2017 and to assess their microvascular and macrovascular complications.A retrospective anal...

Introduction: The actual prevalence of early carbohydrate metabolic disorders is associated with persistent hyperglycemia and can only be detected by targeted screening.Objective: We examined 316 people aged 51.21(46.7;62.35) years, without DM.Methods: We determined the 10-year risk of T2DM according to the Findrisc scale, anthropometric data, lipid profile, glycemia and HbA1c level, linear dimensions of preperitoneal and subcuteno...

Introduction: The primary incidence of T1DM in children in Belarus is 19.27‰. It’s noteworthy, modern training programs of Schools of Diabetes include questions of the psychological state.Objective: The study included 26 parents of children diagnosed with T1DM.Methods: we used questionnaire to assess the attitude of parents to child’s disease, HADS and social adaptation self-evaluation scales (T. Holmes, R. Ray).<...

Introduction: Mauriac syndrome is characterized by delayed growth and development, obesity, hepatomegaly and elevated transaminases in type 1 diabetes mellitus (T1DM) patients who have poor glycaemic control. Usually recognized in adolescence, when growth failure and pubertal delay became notorious.Case report: A 19-year-old male was referred to the Endocrinology Department due to short stature. He was severely distressed about his stature and younger ap...

Background: Type1 diabetes is the third most common chronic illness in childhood following asthma and cerebral palsy. Adolescence is characterized by physical and psychological changes and there is global evidence suggesting that metabolic control deteriorates during the period of teenage.Aims: To study the characteristics of a group of Tunisian adolescents with type 1 diabetes and describe the various metabolic complications observed.<p class="abste...

Introduction: Adhesive capsulitis (AC) is a condition characterized by spontaneous onset of shoulder pain and gradual loss of active and passive shoulder motion. This condition is more common in people with diabetes. The aim of this study was to appreciate the contribution of different therapeutic means used in physical medicine and rehabilitation (PMR) in the management of AC in Diabetic patients.Patients and Methods: A retrospective study was conducted...

Introduction: Diabetic foot trophic disorders and their complications leading to the risk of amputation remain a major public health problem. The objective of our work was to determine the level of podiatric risk in our diabetic patients according to the classification of the International Working Group of the Diabetic Foot (IWGDF) in order to reduce the rate of amputation and study their level of education and correlate it to podiatric risk.Methods: Thi...

Objective to assess homocysteine and B12 basal levels in patients with diabetes mellitus type 1 (DM type 1) depending on anxiety level.Materials and methods: 163 patients with DM type 1 aged 18–65 years. Diabetes duration is 11.18 [4.28; 22.33] years. The level of anxiety was assessed according to the HADS scale. The homocysteine and vitamin B12 level in serum was determined. Depending on the anxiety level according to the results of the HADS score...

Objective: To analyze correlation between the duration of diabetes mellitus (DM), renal function and androgenic state indicators in patients with DM type 1. 175 males with DM 1 type in the age of 18–55 years (39.75 ± 9.69) with the duration of disease more than 1 year were examined. The control group included 25 almost healthy males in the age 21–41 years (34.60 ± 7.80). The compensation of DM was estimated by the level of glycosylated hemoglobin (HbA1c)....

Introduction: Vitamin D has pleiotropic effect on human body. Several studies showed that vitamin D deficiency has an influence on inflammation status in endocrine diseases (PCO-S, Graves disease, autoimmune endocrine disorders) and could reflect body fat tissue contain. Both, resistin and leptin, show pro-inflammatory effect.Aim: The aim of the study was to asses resistin and leptin serum concentration and its relationship with 25-OH vitamin D concentra...

Background: Obesity is worldwide epidemics and the main risk factor for many diseases. Traditional methods of prevention and treatment of obesity often unfavorable and patients undergo to alternative treatment such as bariatric surgery. To better understanding the pathogenesis of obesity, we aimed to analyse the main abnormalities in blood serum in patients accepted to bariatric surgery.Material and Methods: 27 patients (13 men and 14 women) with obesity...

Ramadan is a holy month in the Muslim religion, it involves a period of daily fasting from sunrise to sunset, which means an average of fifteen hours of fasting during the day (twelve to eighteen hours depending on seasons and regions). In diabetics, this involves metabolic disorders related to fasting, food mode (quantitative and qualitative change in dietary intake). The objective of our study is to define the profile of diabetic patients seen in the emergency department and...

Introduction: Diabetic pregnancy is a high risk pregnancy. The objective of our study was to study the clinical-biological profile of pregnant women with gestational diabetes.Methods: It was a retrospective study of 82 pregnant diabetic women admitted to the day hospital of the National Nutrition Institute in Tunis for the management of gestational diabetes. All patients received regular follow-up until delivery.Results: The averag...

Introduction: Androgen insensitivity syndrome (AIS), also known as testicular feminization, encompasses a wide range of phenotypes that are caused by numerous different mutations in the androgen receptor gene. where there is resistance to androgen actions influencing both the morphogenesis and differentiation of androgen responsive body structures AIS is an X-linked recessive disorder. This disorder includes a spectrum of changes ranging from male infertility to completely nor...

Introduction: The diagnosis of diabetes often precedes the onset of degenerative complications.Method: We report the case of a patient who had consulted for a poor foot plantar perforation evolving for 3 months before the diagnosis of diabetes.Results: He is a 57-year-old active smoking patient with a family history of diabetes and hypertension who presented to the emergency department of the Tunis National Nutrition Institute for ...

Objective: Diabetic ketosis is very often a reason for emergency consultation in diabetics. The objective of our study was to assess the etiologies of ketotic decompensations in diabetics.Methods: It was a descriptive cross-sectional study of 80 diabetics hospitalized at the National Institute of Nutrition for ketotic decompensation. Each patient underwent a clinical examination with a standard biological assessment.Results: The av...

Case presentation: 73-year-old diabetic, hypertensive and alcoholic Male on treatment for type II diabetes for 25 years, underwent amputation of left great toe and second toe previously had sudden painless swelling of the left foot after a walk. He was diagnosed to have Charcot’s foot and had the appearance of bag of bones in CT scan. He was managed conservatively with immobilization and Custom made shoes.Discussion: Charcot foot is a sudden soften...

Introduction: The vascular risk in type 1 diabetics appears to be secondary to the premature development of atherosclerosis.The objective of this study was to determine the characteristics of the lipid profile of a type 1 diabetic population as well as the different factors that can influence these changes.Methodology: It was a descriptive cross-sectional study including 30 type 1 diabetic patients, followed at the National Institu...

Aims: To present an analysis of the evidence related to the prevalence and incidence of diabetes type 1 or type 2 in children and adolescents with intellectual and developmental disabilities, assess available support on managing their diabetes, and the services they receive, investigate the available structured education programs tailored for people with IDD.Methods: We conducted different searches of multiple databases.(PUBMED, ME...

Background: Spondyloarthritis is a chronic inflammatory rheumatic disease which may be associated with different comorbidities such as glucose intolerance.Objectives: Determine the frequency of impaired fasting glucose in a population of patients with spondyloarthritis.Methods: We performed a cross-sectional study including 50 patients with spondyloarthritis (SA) diagnosed according to ASAS criteria. Fasting glucose was measured fo...

Introduction: Disorders of glucose metabolism are often present in chronic liver diseases. The aim of our study is to determine the prevalence and factors associated with type 2 diabetes in patients with cirrhosis.Methods: This is a retrospective study collecting all patients with cirrhosis between January 2010 and December 2019.Results: During the study period, 166 patients were included. Of these patients, 47 patients had type 2 ...

Introduction: NutriScore is a tool designed with the aim of simplifying the information of the nutritional composition obtained from the labelling. It classifies foods into five colors ranging from green (healthier) to red (less healthy). These colors are associated with five letters (A/B/C/D/E).Objective: To examine the nutritional value of foods sold in vending machines of the public hospitals in Community of Madrid (Spain), by calculating the nutrisco...

Introduction: The actual prevalence of early carbohydrate metabolic disorders is associated with persistent hyperglycemia and can only be detected by targeted screening.Objective: We examined 316 people aged 51.21(46.7;62.35) years, without DM.Methods: We determined the 10-year risk of T2DM according to the Findrisc scale, anthropometric data, lipid profile, glycemia and HbA1c level, linear dimensions of preperitoneal and subcuteno...

Patient C., b. 1962 went to the clinic to a urologist with complaints of painful, rapid urination, dry mouth, thirst, a constant feeling of hunger in the daytime. A biochemical blood glucose(bg) level of 10.4 on an empty stomach. At the initial examination by an endocrinologist, bg at a reception of –8.0 mM/l on an empty stomach. BP-134/78 Ps-78. Height-178 Weight-101.5 BMI-32.0. HbA1c-7.4% basal insulin(bi)-28.3 (3.0–25.0) stimulated insulin(si)-56 (3.0–25.0...

Objective: The aim of this study is to assess the balance of diabetes in patients taking insulin analogues based on a recent value for their glycated hemoglobin.Methods: 2915 diabetics were evaluated for the period from March to April 2019 with as inclusion criteria a recent glycated hemoglobin and a duration of insulin treatment analogues of more than one year.Results: Glycated hemoglobin is lower than 7 in only 8% of cases and gr...

Introduction: Condition of injected skin and subcutaneous tissue is assessed by visual inspection and palpation and it has only 10–15% diagnostic value. The standard ultrasonography comparison of symmetrical skin areas is not valuable as they are usually used for injections.Objective: We examined 143 patients, aged 43.3 ± 3.9 years, with DM duration of 6.5 ± 2.8 years, receiving basal-bolus insulin therapy.Methods: ...

Background: Aging patients with type 2 diabetes mellitus have a higher risk of developing hypoglycemia. Many studies show the effect of beta-blockers in hiding hypoglycemia symptoms and therefore the occurrence of a severe hypoglycemia. These agents are commonly used in diabetic patients with coronary heart disease. The aim of this study was to assess whether the use of beta-blockersdeteriorates the glycemic control.Methods: We conducted a retrospective ...

Introduction: Pregnancy in case diabetes complicated by chronic renal failure is characterized by a very high maternal and fetal risk.Method: We report the case of a patient with diabetes and chronic renal failure at the hemodialysis stage who wishes to lead a pregnancy despite all the risks involved and of which she had been informed beforehand.Results: This is a 39-year-old patient, with type 1 diabetes for 26 years. Her diabetes...

Introduction: Malignant or necrotizing external otitis (MEO) is an invasive infection between external auditory canal and skull base. It is more frequent in elderly and in diabetic patients or with compromised immune system. As MEO advance osteomyelitis can developed. It is a severe and potential mortal complication of external otitis (EO).Clinical case: 78 years old man with history of type2 diabetes (good metabolic control) and right ear external otiti...

Introduction: Gastroparesis associated with diabetic autonomic neuropathy is an underdiagnosed complication, although relatively common in diabetes. It is more prevalent in type 1 Diabetes Mellitus (DM1) with more than ten years of disease and especially in patients with poor metabolic control.Clinical case: Female, 37 years old, DM1 with 17 years of evolution with poor metabolic control (HbA1c 9.3%) and several microvascular complications such as prolif...