Endocrine Abstracts

Background: Diabetes-induced prolonged elevated plasma glucose levels result in the formation and accumulation of complex and heterogeneous groups of compounds - advanced glycation end-products (AGEs). AGEs normally accumulate slowly, but this process occurs at a faster rate in patients with conditions such as diabetes or cardiovascular disease. Accumulation of AGEs increases oxidative stress and induces an inflammatory reaction, which has a significant influence on the exacer...

Introduction: Advanced glycation endproducts (AGEs) are sugar-modified products that arise during the non-enzymatic glucose oxidation process. AGEs promote oxidative stress and are associated with poor diabetes mellitus (DM) control, metabolic syndrome, and cardiovascular disease.Objective: to evaluate AGEs accumulation in the diabetic patients‘ skin and its relationship with DM type, disease duration, and complications.Method...

Some studies suggest that Advanced Glycation End products (AGEs) formation represent important and interconnected pathogenic mechanisms in diabetic retinopathy (DR). The aim of this study was to investigate the association of AGEs products with DR in a cohort at Hospital of LHUS. Methods: It was a cross-sectional study of a cohort of adults with type 1 or 2 type diabetes (T1D/T2D).Results: 78 patients with T1D and 81 with T2D were ...