Association of advanced glycation end products with diabetic retinopathy in type 1 and type 2 diabetes

Diana Simoniene; Lina Radzevičienė; Deimantė Paškevičienė; Rasa Verkauskienė

doi:10.1530/endoabs.99.EP236

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Endocrine Abstracts (2024) 99 EP236 | DOI: 10.1530/endoabs.99.EP236

ECE2024 Eposter Presentations Diabetes, Obesity, Metabolism and Nutrition (383 abstracts)

Association of advanced glycation end products with diabetic retinopathy in type 1 and type 2 diabetes

Diana Simoniene ¹ , Lina Radzevičienė ^1,2 , Deimantė Paškevičienė ² & Rasa Verkauskienė ^1,2

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¹Hospital of Lithuanian University of Health Sciences Kaunas Clinics, Endocrinology, Kaunas, Lithuania; ²Institute of Endocrinology, Lithuanian University of Health Sciences Kaunas Clinics, Endocrinology, Kaunas, Lithuania

Some studies suggest that Advanced Glycation End products (AGEs) formation represent important and interconnected pathogenic mechanisms in diabetic retinopathy (DR). The aim of this study was to investigate the association of AGEs products with DR in a cohort at Hospital of LHUS.

Methods: It was a cross-sectional study of a cohort of adults with type 1 or 2 type diabetes (T1D/T2D).

Results: 78 patients with T1D and 81 with T2D were recruited. The overall incidence of any DR was 50.9 %. The prevalence of DR was significantly higher among patients with T1D compared to T2D group (70.5 vs 32.1 %, P<0.001). Patients with T1D had higher risk for DR in comparison to T2D (OR 5,059 [2,578-9,927], P<0.001). Univariate logistic regression revealed that higher risk for DR in T1D was related with diabetes duration > 11 years OR 60,563 [13,75-266,752], P<0,001, mean AGE Reader level>1,8 OR 6,947[2,242-21,526], P=0,003, male gender OR 2,938[1,007-8,569] (P=0,044) and dyslipidaemia OR 3,231[1,103-9,464] (P=0,029). Higher risk for DR in T2D was related with diabetes duration > 13 years OR 4,604 [1,701-12,462], P=0,002, OR 6,947 [2,242-21,526], P<0,001 and albuminuria >6.3 mg/24 hrs OR 10,431[2,681-40,586], P=0,001. In binary logistic regression analysis, the highest risk for DR was associated with dyslipidaemia OR 6 (0.99-36.26) P=0.051 and diabetes duration > 11 years OR 76 (13.63-423.73), P<0.001 in T1D. In T2D DR was associated with HbA1c > 7.5 % OR 7.42 (2.23-24.58), P=0.001 and diabetes duration >13 years OR 4.35 (1.42-13.34), P=0.01.

Conclusions: Diabetic retinopathy prevalence in Lithuanian cohort was 50.9 %. Patients with T1D had a five times higher risk for DR in comparison to T2D. In univariate models, DR in T1D was significantly associated with mean AGE score, diabetes duration, male gender and dyslipidaemia, in T2D - with HbA1c level, increased albuminuria level and diabetes duration. In binary logistic regression analysis, diabetes duration remained the most significant predictor for DR in both types of diabetes. T1D patients with diabetes duration > 11 years and T2D patients with diabetes duration > 13 years, will have the highest rate risk of DR.