Searchable abstracts of presentations at key conferences in endocrinology

ea0021oc1.1 | Diabetes and metabolism | SFEBES2009

IGF1 receptor and insulin receptor stoichiometry is a critical determinant of nitric oxide bioavailablity

Abbas Afroze , Viswambharan Hema , Imrie Helen , Rajwani Adil , Wheatcroft Stephen , Grant Peter , Kearney Mark

Introduction: Accumulating evidence suggests a role for IGF1 in insulin resistance and cardiovascular disease. IGF1 enhances glucose uptake and nitric oxide (NO) production, via similar mechanisms to insulin. Previously we have reported a mouse model with global heterozygous knockout of the IGF1 receptor (IGF1RKO) that has enhanced insulin sensitivity and increased nitric oxide (NO) production in the vasculature.Methods: To investigate this further we us...

ea0019p140 | Diabetes, Metabolism and Cardiovascular | SFEBES2009

Heterozygous knockout of the insulin-like growth factor 1 receptor in mice leads to impaired glucose tolerance, enhanced insulin sensitivity and increased endothelial basal nitric oxide production

Abbas A , Imrie H , Viswambharan H , Rajwani A , Kahn M , Cubbon R , Gage M , Wheatcroft S , Grant P , Kearney M

Introduction: Insulin-like growth factor 1 (IGF-1), acting via similar signalling pathways to insulin, enhances glucose uptake and nitric oxide (NO) production. Observational studies suggest a role for (IGF-1) in insulin resistance and cardiovascular disease. To investigate this further we used a murine model with heterozygous knockout of the IGF-1 receptor.Methods: Metabolic tolerance tests were performed in vivo on unanaesthetised mice, heterozy...

ea0015p149 | Diabetes, metabolism and cardiovascular | SFEBES2008

Metabolic and vascular IGF-1 resistance is a marker of dietary-induced obesity

Imrie Helen , Viswambharan Hema , Rajwani Adil , Abbas Afroze , Cubbon Richard , Kahn Matthew , Gayle Chris , Wheatcroft Stephen , Kearney Mark

Endothelial dysfunction is a key step in the initiation of atherosclerosis, resulting from a decrease in bioavailability of nitric oxide (NO). IGF-1 may play a part in regulation of NO production via the PI3-kinase/Akt/eNOS pathway. We have investigated whether disturbances of this pathway occur in dietary-induced obesity.Obesity was induced in mice fed a high fat diet for 20 weeks (n=12), compared to chow fed controls, with an age-related increas...