Endocrine Abstracts

Introduction: Hypothyroidism and hyperthyroidism are commonly encountered medical disorders that can be associated with neurologic and neuromuscular dysfunction. Muscle involvement is a common manifestation of both clinical and subclinical hypothyroidism, although this may not always be clinically appreciated. Hypothyroid associated myopathy can cause weakness, cramps, aching and painful muscles, sluggish movements and Severe myopathy secondary to hypothyroidism leading to Rha...

Here we present a 49 year-old-male patient with known T1DM, hypothyroidism on Levothyroxine, with previous history of poor compliance with his Levothyroxine. He was admitted with 3 days history of bilateral feet swelling and foot droop. Following the improvement of his leg swellings, his bilateral foot droop became more prominent. He was diagnosed with Hashimoto hypothyroidism with anti TPO ab levels of 279 IU/Ml (reference range: <34 IU/ml) in 2012. His regular medication...

A 46-year-old male was brought to the hospital by his uncle as he was found to be acutely confused and agitated ‘talking rubbish’ and giggling inappropriately. Last time he was seen well was 3 days ago. He was a cyclist who lived alone and his past medical history included Graves’ disease and AF. He was on propranolol, carbimazole and warfarin. A month ago he needed admission to a different hospital after falling off his bike. At that time he also developed conf...

Background and aims: Subjects with primary (PAI) and secondary adrenal insufficiency (SAI)/hypopituitarism have an increased cardiovascular mortality for reasons that are unclear. Arterial stiffness is an independent risk factor for increased cardiovascular mortality. We sought to measure arterial stiffness in subjects with AI and aimed to identify which factors might account for any increase observed.Methods: Ethical approval was obtained for this study...

Background: Women with epilepsy may be at risk of developing PCOS, but it is unclear whether this is due to the disease or sodium valproate (VPA) therapy. We sought to determine androgenic status and cardiometabolic risk in women taking VPA monotherapy and compared these with subjects taking lamotrigine and healthy controls.Methods: Patients with epilepsy (age 18–43) with no known vascular risk were divided into 3 groups: VPA monotherapy (n=1...

Introduction: Graves’ disease (GD) is associated with cardiac complications like tachydysrythmias, coronary ischaemia and cardiomyopathy. They are uncommon in the young. We present three individuals without previous cardiac disease, who developed significant cardiac complications of GD.Case presentations Subject 1: A 34-year-old female smoker, presented with breathlessness, palpitations, tremors and agitation for several weeks. Her fT4 was ...