Endocrine Abstracts

A 27 year old woman was examined in 1977 because of amenorrhea andhirsutism. Hormonal evaluation revealed elevated levels of gonadotrophins simoultaneously with biochemical and clinical hyperandrogenism. Cytogenetic evaluation confirmed presence of male karyotype (46XY) and Swyer syndrome (pure gonadal dysgenesis) was diagnosed. Patient underwent laparotomy, however no gonadal tissue was found during this procedure. A few years later molecular genetic evaluation...

Objectives: There is a growing evidence suggesting an impact of endocrine distrupting chemicals, including bisphenol A (BPA) on human reproduction. Insulin growth factors (IGF) play signifcant role inhuman reproduction. However the relationship between BPA and IGF system is unknown. Aim of the pilot study was to assessthe relationship between urinary BPA (U-BPA) and insulin growth factors (IGF-1, IGF-2, IGFBP 3) as well as metabolic parametersin PCOS women.<p class="a...

IntroductionMedian nerve neuropathy is commonly associated with acromegaly.ObjectiveThis study aims to investigate ultrasound examination of median nerve in acromegalic patients and assess the relationship with activity and duration of disease.Patients and methodsWe prospectively examined the cross sectional area (CSA) of median nerve with high-resolution ultrasou...

Objective: The most common type of pituitary diseases are pituitary adenomas (PA) of different origin. Although non-metastasizing, they still cause increased mortality and morbidity. Clinically significant PAs affect around 0.1% of population during lifetime. Circulating cell free DNA (ccfDNA) is approximately 165 bp long DNA fragments which are released in bloodstream upon cell death. ccfDNA has been used to investigate presence and properties of various cancers. Data on ccfD...