Searchable abstracts of presentations at key conferences in endocrinology

ea0041ep379 | Clinical case reports - Thyroid/Others | ECE2016

Calcific uremic arteriolopathy (Calciphylaxis): case report

Egshatyan Lilit , Rozhinskaya Lyudmila

Introduction: The calcific uremic arteriolopathy (CUA) is one of the several types of extra-osseous calcification that may occur in patients with end-stage renal disease (ESRD). CUA is a serious disorder characterized by calcification of the arterioles that leads to ischemia and subcutaneous necrosis. The pathogenesis is poorly understood, and the optimal treatment is not known.Case report: We present the case of a 64-year-old female with ESRD on hemodia...

ea0037ep685 | Pituitary: basic and neuroendocrinology | ECE2015

The relationship of genetic factors to the development of nephrolithiasis in primary hyperparathyroidism

Peretokina Elena , Mokrysheva Natalia , Rozhinskaya Lyudmila , Zakharova Ekaterina

Factors affecting the development of nephrolithiasis (NL) in primary hyperparathyroidism (PHPT) actively studied. CASR polymorphisms may be linked with the development of NL in PHPT. Supposed to the role of VDR in the development of nephrolithiasis in patients without PHPT.Objective: To assess the relationship of polymorphisms CASR and VDR with the development of the NL at PGPT.Methods: The study included 187 patients with PTPT (54...

ea0037ep705 | Pituitary: basic and neuroendocrinology | ECE2015

Association of polymorphisms of VDR and CASR with clinical and laboratory manifestations of primary hyperparathyroidism

Peretokina Elena , Mokrysheva Natalia , Rozhinskaya Lyudmila , Zakharova Ekaterina

Clinical manifestations and severity vary considerably primary hyperparathyroidism (PHPT) patients. Several studies indicate that the variation of clinical manifestations PHPT may be associated with genetic factors, in particular the VDR gene polymorphisms and CASR. The purpose of this study was to evaluate the effect of VDR gene polymorphisms and CASR on indicators calcium and phosphorus metabolism, levels of 25(OH)D, PTH, and condition of bone density in patients with PHPT.<...

ea0049ep881 | Growth hormone IGF axis - basic | ECE2017

The levels of decorin in patients with Cushing’s disease and acromegaly

Tsoriev Timur , Belaya Zhanna , Rozhinskaya Lyudmila , Ilyin Alexandr , Nikankina Larisa , Mel'nichenko Galina , Dedov Ivan

Decorin is myokine expressed and released in response to muscle contractions. It induces growth and hypertrophy of skeletal muscles in different ways including myostatin inhibition. It is still not clear whether decorin takes part in development of muscle atrophy in endocrine pathologies.Objective: To evaluate decorin levels in patients with endogenous hypercortisolism and GH oversecretion.Materials and methods: Three groups were i...

ea0037ep1091 | Endocrine tumours | ECE2015

Mutation in CDKN1B 3′-UTR region in a patient with acromegaly and primary hyperparathyroidism

Mamedova Elizaveta , Mokrysheva Natalia , Pigarova Ekaterina , Przhiyalkovskaya Elena , Vasiliev Evgeniy , Rozhinskaya Lyudmila , Tiulpakov Anatoliy

Introduction: Multiple endocrine neoplasia type 4 (MEN4) is a rare disorder, caused by inactivating mutations in CDKN1B gene that encodes p27kip1 cyclin-dependent kinase inhibitor. To date nine different germline CDKN1B mutations have been described in patients with clinical features of multiple endocrine neoplasia type 1 (MEN1) negative for MEN1 mutations (MEN1 phenocopies).Case report: We present a female 54 y.o. w...

ea0026p204 | Pituitary | ECE2011

Efficacy of transsphenoidal surgery in treatment of Cushing’s disease: factors influencing postsurgical outcome

Molitvoslovova Natalia , Mamedova Elizaveta , Grigoryev Andrey , Kolesnikova Galina , Rozhinskaya Lyudmila , Arapova Svetlana , Marova Evgeniya

The study analyses direct postoperative and long-term results of surgical treatment of ACTH-secreting pituitary adenomas in 158 patients, operated between 2004 and 2009. There were 143 (91%) female and 15 (9%) male. The mean age of the patients was 36 years, S.D. 10.7. In all patients the diagnosis of Cushing’s disease was confirmed by high dose dexamethasone suppression test. Preoperative hormonal evaluation: ACTH (0800 h), pg/ml (Me-78.5 (50.5 (25th perce...

ea0022p652 | Neuroendocrinology and Pituitary (<emphasis role="italic">Generously supported by Novartis</emphasis>) | ECE2010

A case of giant prolactinoma in a 14-year old boy

Giniyatullina Ekaterina , Dzeranova Larisa , Grigoriev Andrey , Voronzov Alexander , Pigarova Ekaterina , Rozhinskaya Lyudmila

Prolactinomas are very rare, but usually more aggressive among children, than in adults. Although treatment strategies for prolactinomas in adults are well established and at present time the preference is given to dopamine agonists, the use of these drugs in pediatric patients is limited due to lack of information on safety and efficiency in this group of patients.A 14-year old boy presented with absent puberty, obesity (weight +4σ) general weaknes...