Searchable abstracts of presentations at key conferences in endocrinology

ea0094p344 | Metabolism, Obesity and Diabetes | SFEBES2023

An unexpected food-aversion in mice lacking functional leptin signalling

Curtis Anna , Jayal Yashoda , Zhou Zijing , Akalestou Elina , S Dhillo Waljit , G Murphy Kevin , M Owen Bryn

Defending body weight is a fundamental homeostatic process. Indeed, countless studies have demonstrated weight-maintaining hyperphagia in response to either increased energy expenditure or a reduction in the caloric density of available food. The principal effector of this adaptive food intake is thought to be the adipose tissue-derived hormone, leptin. According to the classical ’adipostat’ model, the hypoleptinemia resulting from weight loss drives food intake to r...

ea0094p116 | Reproductive Endocrinology | SFEBES2023

Patient and healthcare providers experience of access to menopause-related information and menopause-care provision across the UK: Results from a nationwide survey

Koysombat Kanyada , Pedder Hugo , Vinogradova Yana , Qayum Ambreen , N Comninos Alexander , Talaulikar Vikram , Panay Nick , S Dhillo Waljit , Mukherjee Annice , Abbara Ali

Menopause management guidelines advocate a personalised, evidence-based approach to menopause-care. This study explored the current landscape of menopause-care, from both patients’ and healthcare-providers’ perspectives, to better understand barriers to menopause-care across the UK.Methods: A 25-question online patient-survey and a 23-question GP-survey was designed with individuals with lived-experience of menopause to underst...

ea0094p267 | Reproductive Endocrinology | SFEBES2023

Kallmann syndrome with unilateral anosmia

Tsoutsouki Jovanna , N Comninos Alexander , Phylactou Maria , Chia Eng Pei , Patel Bijal , Modi Manish , Young Megan , Papadopoulou Deborah , R Howard Sasha , S Dhillo Waljit , Abbara Ali

Introduction: Kallmann syndrome (KS) is a rare genetic disorder typically due to defective migration of olfactory-axons and GnRH-neurons. KS results in congenital hypogonadotrophic hypogonadism (CHH) typically associated with absent (anosmia) or reduced (microsmia) sense of smell. Unilateral hypoplastic/absent olfactory bulbs on MRI are reported, although disturbance in smell is usually bilateral. Here, we present an unusual case of KS with unilateral anosmia....

ea0094p371 | Neuroendocrinology and Pituitary | SFEBES2023

GnRH neuronal disruption and hypotestosteronemia in COVID-19

Sauve Florent , Nampoothiri Sreekala , Clarke Sophie , Fernandois Daniela , Fernando Ferreira Coelho Caio , Dewisme Julie , G Mills Edouard , Ternier Gaetan , Cotellessa Ludovica , Iglesias Garcia Cristina , Mueller-Fielitz Helge , Lebouvier Thibaud , Perbet Romain , Florent Vincent , Baroncini Marc , Sharif Ariane , Ereno-Orbea June , Mercado-Gomez Maria , Palazon Asis , Mattot Virginie , Pasquier Florence , Catteau-Jonard Sophie , Martinez-Chantar Maria , Hrabovszky Erik , Jourdain Merce , Deplanque Dominique , Morelli Annamaria , Guarnier Giulia , Storme Laurent , Robil Cyril , Trottein Francois , Nogueiras Ruben , Schwaninger Markus , Pigny Pascal , Poissy Julien , Chachlaki Konstantina , Maurage Claude-Alain , Giacobini Paolo , S Dhillo Waljit , Rasika S , Prevot Vincent

Loss of gonadotropin-releasing hormone (GnRH) and cognitive deficits have recently been demonstrated by our group in conditions including Down syndrome and Alzhiemer’s disease. In some patients with COVID-19, olfactory and cognitive alterations persist, and persistent hypotestosteronemia in SARS-CoV-2-infected men could be a consequence of deficient GnRH. To understand whether neuroinvasion of GnRH system by SARS-CoV-2 could explain some post-COVID symptoms and thus resul...