Endocrine Abstracts

Aim: Audit the management of patients with thyrotoxicosis in the thyroid clinic at a District General Hospital, focusing on treatment methods and long term follow up.Method: Prospective data collected from randomly selected 50 case notes and laboratory results over 4 months. Titration dose with Carbimazole or Propylthiouracil with close monitoring of thyroid function test is the treatment method followed.Results: Eighty-six percent...

A 30 year old gentleman presented with long standing symptoms of polyuria and polydypsia and poor libido. On examination he was short (155 cm), weighed 108 kg with a body mass index of 45.1. Investigations revealed normal Blood Glucose, renal function, liver function and calcium. Water deprivation test confirmed the diagnosis of Cranial Diabetes Insipidus. He was started on DDAVP tablets 100 microgram’s twice daily. Further tests showed a normal IGF-1, synacthen test and ...

Objective: Change in somatostatinergic tone (SST) is one of the key features of acromegaly, but the effect of tumor size on SST is not clear.Design: The aim of this study was to determine how SST changes depending upon the size of GH-producing pituitary tumors.Method: GH levels of 29 patients with newly diagnosed acromegaly were measured using a 75 g oral glucose tolerance test (OGTT), an insulin tolerance test (ITT) and an octreot...

Objective: TRH induces GH secretion presumably by expression of TRH receptor dedifferentiated in pitutiary tumors, but it is not clear how the TRH elegantly stimulates GH secretion in tumoral states.Design: The aim of this study was to investigate how GH-producing pituitary adenomas respond to TRH with respect to GH secretion and how it differs according to octreotide responses and their sizes of tumor.Method: GH levels of 45 patie...

Objectives: Patients with acquired growth hormone (GH) deficiency secondary to hypopituitarism, have a significant increased risk of cardiovascular events. However, variable data of the effects of GH replacement and its benefits reducing such risk, is available. The aim of this study was to determine the impact of 0.4 milligrams of GH on cardiovascular markers in severe GH deficient adults with hypopituitarism.Methods: A total of 17 patients (10 males an...

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Promotion of angiogenesis, the formation of new blood vessel from preexisting blood vessels, is the focus of intense research and therapeutic efforts. In contrast, inhibition of endothelial cell growth and survival is a strategy to target many proliferative diseases. Various studies have shown that angiogenic growth factors are produced and secreted by normal endocrine cells and are increased in pathological states, including inflammation and hyperplasia. Importantly, angiogen...

The limitations of s.c. insulin lead to post prandial hyperglycaemia and a high risk of hypoglycaemia particularly in the post-absorptive state. Nocturnal hypoglycaemia continues to be a common and major problem for patients with insulin treated diabetes and is a major barrier in preventing patients reaching tight glycaemic targets.The development of basal insulin analogues, insulin glargine and insulin detemir which deliver insulin over a longer period ...

Whilst the rise in the prevalence of obesity has been driven by environmental factors, there is considerable evidence that body weight and fat mass are highly heritable traits. Differences in susceptibility to obesity between individuals have strong genetic determinants.Our strategy has been based on studies of patients with severe obesity where we hypothesised that major highly penetrant genetic variants were likely to be playing an important role.<...

Testosterone is a vital hormone in women, circulating in nanomolar concentrations. Not only is testosterone a precursor for estradiol biosynthesis in the ovaries and extragonadal tissues, but testosterone acts directly via androgen receptors throughout the body. Levels decline with age in women with the greatest fall in total and free testosterone occurring before the menopause. Large RCTs involving naturally and surgically postmenopausal women presenting with hypoactive sexua...